temozolomide resistance
HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines
... of resistance of treatment, including TMZ treatment, independent of the MGMT methylation status of the tumor ...[9]. Temozolomide resistance in the high HOXA9/HOXA10-expressing GBM cell line was ...
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Original Article MiR-16 modulate temozolomide resistance by regulating BCL-2 in human glioma cells
... to temozolomide, while sen- sitivity to temozolomide was increased by treat- ment with the miR-16 ...TMZ resistance in glioma ...of temozolomide resistance ...
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Temozolomide resistance in glioblastoma occurs by miRNA-9- targeted PTCH1, independent of sonic hedgehog level
... Glioblastoma Multiforme (GBM), the most common and lethal adult primary tumor of the brain, showed a link between Sonic Hedgehog (SHH) pathway in the resistance to temozolomide (TMZ). PTCH1, the SHH ...
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Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
... An emerging concept in cancer biology suggests that specific subpopulation of cells has a greater survival ad- vantage in a challenging environment and that they maintain their ability to form a tumor and become re- ...
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Tbx2 confers poor prognosis in glioblastoma and promotes temozolomide resistance with change of mitochondrial dynamics
... and resistance to chemothera- peutic drugs has not been investigated yet in ...used temozolomide (TMZ) (50 μ M) to treat U251 and A172 cells transfected with Tbx2 siRNA or plasmid for 24, 48, and 72 ...
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<p>Induction Of XLF And 53BP1 Expression Is Associated With Temozolomide Resistance In Glioblastoma Cells</p>
... Results: We found that non-homologous end joining (NHEJ), which is one of the major DNA double-strand break repair pathways, participates in acquired TMZ-resistance in GBM. Canonical NHEJ key factors, XLF and ...
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<p>EDNRB isoform 3 confers Temozolomide resistance in A375 melanoma cells by modulating membrane potential, reactive oxygen species and mitochondrial Ca<sup>2+</sup></p>
... TMZ resistance, but not other apoptosis inducers such as STS, etoposide and TBH70X, indicating that EDNRB isoform 3 is involved in alkylating agents induced cell ...TMZ resistance such as cytochrome c ...
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The miR-26a/AP-2α/Nanog signaling axis mediates stem cell self-renewal and temozolomide resistance in glioma
... Gliomas are the most aggressive, common and devastating primary brain tumors, and have a dismal prognosis and limited treatment options [1]. The standard of care for glioma patients includes surgery followed by combined ...
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H19 induced by oxidative stress confers temozolomide resistance in human glioma cells via activating NF-κB signaling
... Our study provides more insights into the potential role and mechanism of H19 in glioma TMZ resistance. Neverthe- less, there are still some limitations in our study. For instance, our results are based on ...
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Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth
... The cellular responses to two new temozolomide (TMZ) analogues, DP68 and DP86, acting against glioblastoma multiforme (GBM) cell lines and primary culture models are reported. Dose-response analysis of cultured ...
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Metformin treatment reduces temozolomide resistance of glioblastoma cells
... It has been reported that metformin acts synergistically with temozolomide (TMZ) to inhibit proliferation of glioma cells including glioblastoma multiforme (GBM). However, the molecular mechanism underlying how ...
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Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma
... that its expression in initial lesions was an indicator of reduced patient survival [6]. On the other hand, Flesberg et al. showed that the expression of MSH6, MSH2, and PMS2 were reduced in recurrent GBM, but that MLH1 ...
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A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide
... of temozolomide response in ...in temozolomide response, including down-regulation of MMR family proteins PMS2 and MSH6 (Figure ...of resistance to alkylating agents, including temozolomide ...
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The impact of bevacizumab treatment on survival and quality of life in newly diagnosed glioblastoma patients
... Abstract: Glioblastoma multiforme (GBM) remains one of the most devastating tumors, and patients have a median survival of 15 months despite aggressive local and systemic therapy, including maximal surgical resection, ...
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Profile of capecitabine/temozolomide combination in the treatment of well-differentiated neuroendocrine tumors
... as temozolomide under continuous exposure to an antimetabolite such as capecitabine could be ...preceded temozolomide by 9 ...cell resistance to alkylating agents such as ...with temozolomide ...
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Effective long-term temozolomide rechallenge in a macroprolactinoma
... Our patient was affected by a macroprolactinoma that acquired resistance to treatment and an aggressive behavior after partially successful prolonged treatment with Cab (persistence o[r] ...
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Targeting autophagy to sensitive glioma to temozolomide treatment
... Nuclear factor E2-related factor 2 inhibition Nuclear factor E2-related factor 2 (Nrf2), a pivotal transcriptional factor of cellular responses to oxidative stress, is observed to function remarkably in glioblast- oma ...
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Treating malignant glioma in Chinese patients: update on temozolomide
... rates. Resistance to radiation and chemotherapy is the main problem in the treatment of malignant glioma and reflects multiple mechanisms, includ- ing molecular resistance to DNA damage and apoptosis, ...
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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF TEMOZOLOMIDE AND CAPECITABINE IN SYNTHETIC MIXTURE
... alkylating agent class. It is official in IP and USP. IP [3] and USP [4] describe liquid chromatography method for its determination. Literature survey reveals spectrophotometric, [5] HPLC, [6] colorimetric [7] and LC/MS ...
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CONCEPT OF DECEPTIVE SIMILARITY UNDER TRADEMARK LAW IN INDIA AND USA
... mark ―Temoget‖ in respect of pharmaceuticals products Temozolomide on the ground that the mark ―Temoget‖ is deceptively similar to Plaintiff registered trademarks ― Temodal‖[r] ...
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