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TGF-β1/Smad3

Original Article NLRC5 silencing improves cardiac fibrosis by regulation of TGF-β1/Smad3 signaling pathway

Original Article NLRC5 silencing improves cardiac fibrosis by regulation of TGF-β1/Smad3 signaling pathway

... of TGF-β1/Smad3 signaling play an important role in the development and progres- sion of cellular fibrosis ...in TGF-β1-induced cardiac ...in TGF- β1-incubated cardiac ...

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Original Article Chitosan inhibits fibroblasts growth in Achilles tendon via TGF-β1/Smad3 pathway by miR-29b

Original Article Chitosan inhibits fibroblasts growth in Achilles tendon via TGF-β1/Smad3 pathway by miR-29b

... by TGF-β1/Smad3 ...of TGF-β1 and p-Smad3 were decreased while the expression of miR-29b was increased by chitosan in rat repaired tendon tissue and ...of TGF-β1 in ...

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Silencing TRIP13 inhibits cell growth and metastasis of hepatocellular carcinoma by activating of TGF-β1/smad3

Silencing TRIP13 inhibits cell growth and metastasis of hepatocellular carcinoma by activating of TGF-β1/smad3

... synthesis, TGF-β1 participates in various complicated physiological and pathological processes, for example, embryo development, inflammation, angiogenesis, fibro- sis and carcinogenesis, in a human body ...

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Original Article Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro

Original Article Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro

... that TGF-β1/ Smad3 signaling plays a pivotal role in EMT. TGF-β1 binds to its receptors to phosphorylate receptor-regulated ...tion Smad3 complexes translocate into nucle- us to ...

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Original Article Peroxiredoxin-1 attenuates hepatic fibrosis by inhibiting TGF-β1/Smad3 and ROS signal pathways

Original Article Peroxiredoxin-1 attenuates hepatic fibrosis by inhibiting TGF-β1/Smad3 and ROS signal pathways

... the TGF-β1 mRNA was also demon- strated in the liver of DMN-treated mice (Figure ...of Smad3 (p-Smad3) was concomitantly increased in DMN livers (Figure 2B), which was associat- ed with robust ...

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Targeted disruption of TGF β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Targeted disruption of TGF β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

... in Smad3-null ...of Smad3-null mice (Figure 3, a and ...either Smad3-null littermates or sham-operated wild-type mice (Figure ...with Smad3-null mice (Fig- ure 3, d and ...in Smad3-null ...

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The expression of TGF β1, Smad3, phospho Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas

The expression of TGF β1, Smad3, phospho Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas

... of TGF-β ligands and down- stream signaling mediators has been studied in many types of tumors, and the results are discordant ...of TGF-β signaling in the develop- ment and invasion of NFPAs has not been ...

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/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region

/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region

... the TGF-β1 growth-inhibitory effects in cancer ...of Smad3 tumor suppressive function through linker phosphorylation ...restore TGF-β1 growth-inhibitory response in cancer ...

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Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin- Smad3 feedback circuit

Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin- Smad3 feedback circuit

... 25]. TGF-β1 is one of the best-known inducers ...upon TGF-β1 ...by TGF-β1 and the underlying mechanism remain ...including TGF-β1 ...how TGF-β1 can ...

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Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling

Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling

... [20]. TGF-β1 has been shown to be upregulated in OC and an increasing number of studies has found that in ovarian clear cell carcinomas, the expression of TGF-β1 promotes cancer stem cell ...

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Tenofovir alafenamide fumarate attenuates bleomycin-induced pulmonary fibrosis by upregulating the NS5ATP9 and TGF-β1/Smad3 signaling pathway

Tenofovir alafenamide fumarate attenuates bleomycin-induced pulmonary fibrosis by upregulating the NS5ATP9 and TGF-β1/Smad3 signaling pathway

... The nucleoside reverse transcriptase inhibitor tenofo- vir alafenamide fumarate (TAF) is widely used to treat human immunodeficiency virus and hepatitis B virus (HBV) infections [25 – 27]. A 5-year open-label follow-up ...

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Original Article Effect of octreotide on pancreatic fibrosis in rats with high-fat diet-induced obesity

Original Article Effect of octreotide on pancreatic fibrosis in rats with high-fat diet-induced obesity

... (TGF-β1), Smad3, and Smad7 in the pancreas were ...CTGF, TGF-β1, and Smad3 in the HFD group were increased relative to the control group, but Smad7 expression was ...CTGF, ...

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Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1

Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1

... to TGF-β1 (ab64715, 1:1000), Smad2 (ab119907, 1:1000), Smad3 (ab75512, 1:5000), E-cadherin (ab1416, 1:50), N-cadherin (ab98952, 1:1000), Vimentin (ab8978, 1:1000) and β-actin (ab8226, ...

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Distinct expression profiles of TGF β1 signaling mediators in pathogenic SIVmac and non pathogenic SIVagm infections

Distinct expression profiles of TGF β1 signaling mediators in pathogenic SIVmac and non pathogenic SIVagm infections

... and TGF- β 1 (active and latent) responses ...gata-3, smad3, smad4 and smad7 transcripts was per- formed by using Taqman gene expression assays devel- oped by Applied ...

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Original Article Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid arthritis

Original Article Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid arthritis

... of TGF-β1, Smad2/ Smad3 and p-Smad2/Smad3 (diluted at 1:1000, Cell Signaling Technology, Boston, MA, USA), as well as anti-rat primary antibody of β-actin (diluted at 1:3000, Becton Dickinson, ...

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Original Article Smad2 and Smad3 play differential roles in the regulation of matrix deposition-related enzymes in renal mesangial cells

Original Article Smad2 and Smad3 play differential roles in the regulation of matrix deposition-related enzymes in renal mesangial cells

... of TGF-β1 to its receptor II (TβRII) results in phosphoryla- tion of the TGF-β receptor type I (TβRI)-kinase, which in turn phosphorylates the two receptor- regulated Smads (Smad2 and ...and ...

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Original Article Effect of TGF-β/Smads signaling in patients with osteoarthritis and osteoarthritis rat model

Original Article Effect of TGF-β/Smads signaling in patients with osteoarthritis and osteoarthritis rat model

... investigation. TGF-β1, Smad2, and Smad3 mRNA elevated in the process of OA modeling and lasted for a period of ...of TGF-β in OA have been widely report- ed. TGF-β/Smad signaling ...

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Original Article LncRNA TUG1 ameliorates diabetic nephropathy by inhibiting miR-21 to promote TIMP3-expression

Original Article LncRNA TUG1 ameliorates diabetic nephropathy by inhibiting miR-21 to promote TIMP3-expression

... genes TGF-β1, α-SMA, P-Smad3, t-Smad3, CTGF, Fibronectin, and Collagen I were signifi- cantly decreased, while in siTUG1 cells, these maker genes were significantly up-regulated (Figure ...

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TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5

TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5

... of TGF-β signaling in mammalian cells ...of TGF-β1 in Aβ-injected rats ...on TGF-β1-suppressed microglia clustering and its concurrent effects on inhibiting SMAD2 phosphorylation and ...

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Deletion of Smad3 improves cardiac allograft rejection in mice

Deletion of Smad3 improves cardiac allograft rejection in mice

... of Smad3 from the recipients resulted in a shift of immune response from the Th1 to the Th2 in cardiac allografts, which is consistent with the alloskin rejection ...whereby Smad3-deficiency improved ...

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