13:The cells of the tumour microenvironment
Immune profiling of the tumour microenvironment in prostate cancer
... PC3M cells were prepared in RPMI supplemented with full serum at 5 x 10 5 ...4 cells) were placed onto the underside of the filter (which was now the ...allow cells to attach to the ...Stained ...
186
Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs
... infected cells microenvironment and the advantage of this local transfer for virally infected ...infected cells, much lower levels are sufficient to regulate their target genes and to induce aerobic ...
24
A review on the interactions between the tumour microenvironment and androgen receptor signaling in prostate cancer
... epithelial cells and within the cells of the TME and how AR interacts with local ...immune cells directly killing tumour cells and secreting cytokines to control malignant cell growth ...
36
The role of mesenchymal stem cells in the tumour microenvironment
... The data from analyses performed in this chapter highlight the highly responsive and conditional nature of MSCs, demonstrating that exposure to the secretome of cancer cells and cancer-‐associated myofibroblasts ...
224
Adrenomedullin and tumour microenvironment
... in tumour progression is becoming more relevant with recent ...the tumour cells but also by numerous stromal cells including macrophages, mast cells, endothelial cells, and ...
15
The hypoxic tumour microenvironment
... cancer cells and provide them with building blocks 36–39 ...enhancing tumour growth in murine mammary cancer models 40 ...cancer cells 41 ...reduced tumour resilience and metastatic potential, ...
13
Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour
... dead cells) due to oxygen starvation, is a transient property in all cases except where the oxygen consumption rate is very ...dead cells in the middle of the tumour mass can be generated without ...
29
Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
... various tumour types [ 182 ...multiple tumour types (breast, lung, colon, melanoma, GBM, and prostate) [ 183 ...deficient cells show increased sensitivity to metabolic stress and were predictive of ...
40
Adapting Immunotherapy to the Tumour Microenvironment
... • Engineer CAR-T cells to synthesise arginine precursors. Strong in vivo efficacy data: enhanced proliferation, increased anti-tumour activity, prolonged survival (publication – PMID:32573723, patent ...
11
Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
... tumor microenvironment in ...cancer cells, it allows better kinetic examination of important cancer progression stages such as angiogenesis, intravasation, and extravasation in a controlled ...
56
Understanding the Role of the Solid Tumour Microenvironment in Brain Tumour Progression
... of cells. To track cells it is necessary to compare images taken at different time points and identify which cells are the ...neighbouring cells. The ability to track individual cells ...
210
The role of microvesicles in EMT and tumour microenvironment
... of cells. This strict limitation of cells can only be achieved through a well governed regulation of the cell ...for cells undergoing ...target cells in the G1/S phases of the cell ...cancer ...
225
The Role of microRNA-145 in the Tumour Microenvironment
... 1.6.7 miRNA therapies miRNA mimics and antimirs are being developed for the therapeutic treatment of diseases or and cancer. The development of this new class of drugs comes with several challenges to overcome in ...
304
Host microenvironment in breast cancer development Inflammatory and immune cells in tumour angiogenesis and arteriogenesis
... inflammatory cells to a tumour appears to be a common denominator for the major processes involved in tumour development and progression ...Inflammatory cells contribute to tumour ...
6
Development and characterization of a microfluidic model of the tumour microenvironment
... the tumour microenvironment upon drug response, three well-established drugs were ...proliferating cells. Our results showed that DOX was most cytotoxic against cells located at the hydrogel ...
17
Modelling and analysis of the tumour microenvironment of colorectal cancer
... We have introduced a novel method for analysing multiplex image data such as the TIS image data in Chapter 3. It is dierent from previously presented methods in that it considers the samples at cell rather than at pixel ...
154
Role of the Hedgehog pathway in the pancreatic tumour microenvironment
... of tumour [Olive et ...cancer cells) reduced the survival rate of mice with tumour and was associated with an undifferentiated aggressive tumour ...the tumour mass was reduced in these ...
358
Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment
... The term extracellular vesicle encompasses exosomes, microsomes and apoptotic bodies [14,15] . Exosomes are 30 –100 nm in size and are formed from inward budding of the endosomal membrane [16] . This forms a ...
6
Both tumour cells and infiltrating T-cells in equine sarcoids express FOXP3 associated with an immune-supressed cytokine microenvironment
... immune microenvironment in which the replication of BPV infected fibroblast proceeds unchecked by the immune ...grafting tumour explants [13] may now be interpreted as a failure to reject the ...
14
Defining the pro-tumour impact of the evolving stromal microenvironment
... melanoma microenvironment encompasses many of the common pathological features of cancer, described ...these cells often display markers of T-cell dysfunction 23 , which may be induced by expression of ...
264