The circadian clock
The circadian clock in mammals
... the circadian cycle and that CREB can only be phosphory- lated in response to light during the subjective night, sug- gests that gating may occur upstream of the phosphorylation step ...the circadian ...
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The circadian clock and the cell cycle
... the circadian clock may be able to influence the timing of the cell cycle was first proposed by Franz Halberg (Halberg et al, ...the clock had been elucidated that any direct mechanistic links could ...
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The circadian clock coordinates ribosome biogenesis.
... molecular circadian clock gives important insight into the mecha- nisms involved in the generation of these ...molecular clock orchestrates the rhythmic transcrip- tion of clock-controlled ...
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The role of the circadian clock in rheumatoid arthritis
... a circadian component, not just in its symptoms, but in disease ...the circadian clock in regulating the immune response has been ...central clock, and at the local level by autonomous clocks ...
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The effects of the circadian clock on wound healing in skin
... The circadian clock has been shown to be important in several areas of health and disease at the whole organism ...under circadian control (Tanioka et ...the circadian clock can have ...
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Ultradian oscillators of the circadian clock in Saccharomyces cerevisiae
... GAPDH activity cycles with an activity maximum every 24 h in mammalian cells and is controlled by compo- nents of the circadian clock. Previous work has shown that the ENOX1 period in minutes equals the ...
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The circadian clock and darkness control natural competence in cyanobacteria.
... The circadian clock controls numerous processes in ...the clock selectively inhibits cell division during a temporal window during the night, and cells divide freely at other times of the day 28,29 ...
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REVERBa couples the circadian clock to hepatic glucocorticoid action
... the circadian transcription factor REVERBa and co-binding with liver-specific hepatocyte nuclear transcription factors (HNFs) on ...inverted circadian liver GC sensitivity and protected mice from ...
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MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells
... a circadian manner (JTK cycle time = 24 hr; p value = ...that circadian oscillation is not discernible, suggesting that glucose was consumed for biosynthesis as postulated ( Murphy et ...unsuspected ...
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The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration
... Although circadian rhythms are widespread throughout the body, the circadian timing system is ...A circadian clock in the suprachiasmatic nucleus of the hy- pothalamus receives light input ...
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The circadian clock goes genomic
... Recent eff orts to clone crop-domestication genes have revealed that ancient and modern breeding has selected variants in clock components. Th e most notable exam- ples include the transitions of barley and wheat ...
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Testing the Robustness of the Circadian Clock
... functional clock, our reporter does not function in mature EEs or circadian clock function is context dependent in these ...the Clock PER reporter was inserted into the second chromosome at an ...
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The circadian clock goes genomic
... of clock genes has been more highly favored than the retention of genes randomly sampled from the genome [81]; this was not a linkage disequilibrium eff ect, as even the neighboring genes, as known by synteny, were ...
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Circadian Medicine: The Role of the Circadian Clock Mechanism in Cardiovascular Health and Disease
... Physicians recognized the link between rest and the heart over a century ago, as stated by Dr. James Herrick in 1912, “the importance of absolute rest in bed for several days is clear”, referring to the treatment of ...
The circadian clock system’s influence in health and disease
... that clock genes are widely expressed and present in nearly every cell throughout the ...mouse clock system genes ...of circadian processes as some research hasn’t taken advantage of molecular and ...
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Quantitative Trait Loci for the Circadian Clock in Neurospora crassa
... of circadian clocks for the past four ...Two circadian clock phenotypes, free-running period and entrained phase, were evaluated in the 188 F 1 progeny of each mapping ...the clock QTL, we ...
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Probing the Relative Importance of Molecular Oscillations in the Circadian Clock
... the clock is to rhythmically enter the nucleus and repress CLK–CYC, perhaps by providing DBT kinase ...of clock pro- teins, rather than rhythmic levels, is key to the time- keeping process, some aspects of ...
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Molecular mechanisms of circadian clock functioning
... biological CLOCK present in all cells. However, there is also a cen tral CLOCK – the primary circadian pacemaker which is localized in the supraсhiasmatic nuc lei of the mammalian ...this ...
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Frequency doubling in the cyanobacterial circadian clock
... the circadian clock, going from one to two peaks per circadian ...cyanobacterial clock can couple with multi- ple downstream gene circuits to enable the generation of complex gene ...
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Robustness from flexibility in the fungal circadian clock
... the circadian clock of Neuro- spora crassa based on the central FRQ-WC oscillator, incorporating both the frq and wc-1 ...Neurospora clock have modelled the effect of light through direct changes to ...
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