The Hippo Signalling Pathway
Mammalian upstream Hippo signalling pathway proteins activate core pathway kinases and functionally antagonize oncogenic YAP
... the Hippo pathway core kinase cassette has been well characterized in mammalian cells, upstream events are far less well ...the Hippo signalling pathway in mammalian ...the Hippo ...
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Willin as a novel 4 1 ezrin radixin moesin (FERM) domain protein in the mammalian hippo signalling pathway
... core Hippo signalling pathway components MST1/2, LATS1 and YAP, an effect which can be antagonised by ...the Hippo pathway may play a vital role in the developmental reg- ulation within ...
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Influence of the Hippo YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
... in Science revealed an interesting mechanism underlying the inhibition of tumour progression. Differing from the traditional studies that only focus on the autonomous tumour formation roles of YAP/TAZ, Moya et al. ...
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ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer
... FGFR3 signalling in bladder cancer. We show that FGFR3 signalling induces a MAPK/ERK-mediated increase in ETV5 levels, and that this results in increased level of TAZ, a co-transcriptional regulator ...
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The Hippo pathway in colorectal cancer
... The effector of the Wnt signalling (WNTS) path- way is the transcriptional co-activator b-catenin [52]. WNTS ligands include many types of proteins that act as morphogens, controlling cell differentiation and ...
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The Hippo Signaling Pathway in Development and Cancer
... Baena-Lopez, L.A., Rodrı´guez, I., and Baonza, A. (2008). The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like. Proc. Natl. Acad. Sci. USA 105, ...
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The Hippo pathway in disease and therapy: cancer and beyond
... The Hippo tumour suppressor pathway co-ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth ...core Hippo signalling module receives signal inputs on ...
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Regulation of Drosophila intestinal regeneration by the Hippo pathway
... JNK signalling, although the molecular mechanism remains unclear (Sun and Irvine, ...JNK pathway could be responsible for Yki activation in the ...JNK signalling is required for the midgut ...
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The functional characterisation of MOB1-regulated Hippo core cassette kinase signalling
... the Hippo pathway components and YAP/TAZ activities seems promising for anti-cancer targets, there are problems that needs to be ...the Hippo pathway negatively regulates the pathway`s ...
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The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena
... Biological Signalling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, 79104 Germany, § Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, ...
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Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
... canonical Hippo pathways are so highly conserved that human MST2, hMOB1A and LATS1 can compensate for the loss of Hippo, Mats and Warts in ...that Hippo signalling is more diverse and complex, ...
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Analysis of the role of the Hippo pathway in cancer
... The hippo pathway possesses the unique capacity to lead to ...of hippo pathway will be responsible for cancer ...of hippo pathway in different diversity of cancers, and discuss ...
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The Hippo pathway in normal development and cancer
... The Hippo pathway is a central regulator of organ size and tissue ...homeostasis. Hippo kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ, two closely related ...
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The Role of Hippo Pathway in Mitosis and Cancer
... cells. In line with a role of Ajuba in cancer, recent large scale genomic studies found that the Ajuba gene is mutated in 7% of esophageal squamous cell carcinomas [24, 25] and Ajuba is overexpressed in colon cancer ...
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The Hippo Pathway Regulates Hematopoiesis in Drosophila melanogaster
... the Hippo pathway as a key mediator of he- matopoiesis by showing that it controls differentiation and proliferation of the two major types of ...downstream Hippo pathway kinase Warts, lymph ...
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The role of the Hippo pathway in human disease and tumorigenesis
... The Hippo signaling pathway has been demonstrated to play a central role in the regulation of tissue and organ size during ...of Hippo signaling leads to a concurrent combination of uncontrolled ...
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Histone Acetylation-Mediated Regulation of the Hippo Pathway
... The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer ...this ...
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Hippo signaling pathway in liver tissue homeostasis
... 的活性受 Hippo 信号通 路上游信号和激酶级联复合物的严密调控，Hippo 信号通路上游蛋白的突变缺失会导致 YAP/TAZ 的 过度激活，使肝细胞、胆管细胞或卵原细胞大量增 殖，分化受阻，肝脏发育出现异常。但是，在肝脏 组织中特异性敲除 Hippo 信号通路的上下游不同成 员，或者在不同发育阶段敲除相同的成员，则造成 不同类型和不同程度的肝脏发育异常，这些结果表 明 ...
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The functions of the Hippo signaling pathway in immune cells
... 都表明 Hippo 信号通路在不同细胞、组织与器官中 的功能和调控存在着特异性和多样性。在人类中， MST1 突变所导致的主要表型为免疫缺陷综合征， 而非其他组织发育异常或肿瘤产生，表明 MST1 在 免疫系统的综合调控中发挥着重要的作用。Hippo 信号通路在免疫中的研究目前多集中于 MST1 及 MST2 在 T 细胞和部分天然免疫细胞。MST1 在 B 细胞的发育和功能中的研究只局限于最初在 Mst1 ...
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Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance
... the Hippo/YAP pathway in osteosarcoma chemoresistance, we successfully established stable YAP-overexpressing and YAP-knockdown MG63 cell lines by retrovirus and lentiviral ...
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