The locus coeruleus (LC)
Orexin modulates behavioral fear expression through the locus coeruleus
... Emotionally salient information activates orexin neurons in the lateral hypothalamus, leading to increase in sympathetic outflow and vigilance level. How this circuit alters animals’ behavior remains unknown. Here we ...
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The effects of cobalt protoporphyrin IX and tricarbonyldichlororuthenium (II) dimer treatments and its interaction with nitric oxide in the locus coeruleus of mice with peripheral inflammation
... † These authors contributed equally to this work. Received: 23 April 2019; Accepted: 2 May 2019; Published: 5 May 2019 Abstract: Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and ...
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Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
... Abstract The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was ...
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Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
... Abstract The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was ...
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Coordination Mechanism in Dopamine Neurons of the Substantia Nigra Pars Compacta and Norepinephrine Neurons of the Locus Coeruleus
... neuromelanin is a conjugated polymer, and quantum dot/conjugated polymer combinations have been reported in numerous independent studies to generate coherent electron conduction bands for solar photovoltaic applications. ...
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Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation
... Ishida Y, Hashiguchi H, Takeda R, Ishizuka Y, Mitsuyama Y, Kannan H, Nishimori T, Nakahara D (2002) Conditioned-fear stress increases Fos expression in monoaminergic and GABAergic neurons of the locus ...
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Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat
... radiolabeled ligand binding, was selectively decreased only by the appropriate antisense ODNs and not by the "scrambled" ODNs. These antisense ODNs were then administered three times, on alternate days, into the ...
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Pupillometry and P3 index the locus coeruleus– noradrenergic arousal function in humans
... The observation that large phasic pupil dilations were ac- companied by poor task performance appears inconsistent with the prediction that large LC-NE phasic responses should be synchro[r] ...
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Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory Consolidation
... 3 International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba 305-8575, Japan The noradrenergic (NA) projections arising from the locus ceruleus (LC) to the amygdala and bed nucleus of ...
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A role for locus coeruleus in Parkinson tremor
... e-mail: [email protected] We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease (PD), in 12 consecutive PD patients during a specific task activating the locus ...
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In vivo stimulation of locus coeruleus: effects on amygdala subnuclei
... The locus coeruleus (LC) is the major noradrenergic nucleus and sends projections to almost all brain areas. A marked increase in norepinephrine release has been demonstrated in several brain areas in ...
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Sex Differences In Μ-Opioid Regulation Of The Rat Locus Coeruleus
... There are sex differences in disease susceptibility, time of onset of symptoms, and drug responses. Notably, sex differences are particularly prominent in pain and opioid analgesic responses, with females being less ...
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Quantifying the contrast of the human locus coeruleus in vivo at 7 Tesla MRI
... Our aim was to explore whether there are 7T scan sequences that can achieve adequate con- trast for imaging the LC. For reference, we also included the standard TSE sequence used at 3T. The results indicate that several ...
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Altered miRNA expression network in locus coeruleus of depressed suicide subjects
... Bhaskar Roy 1 , Qingzhong Wang 1 , Miklos Palkovits 2 , Gabor Faludi 3 & Yogesh Dwivedi 1 Norepinephrine (NE) is produced primarily by neurons in the locus coeruleus (LC). Retrograde and ultrastructural ...
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Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease
... Clini- cal inclusion criteria for subjects with PD were: (a) diag- nosis according to the UK Parkinson Disease Brain Bank criteria; (b) absence of any signs indicative for aty- pical par[r] ...
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Adolescent Development Determines the Effects of Agonistic Social Stress on Rat Behavior and Locus Coeruleus Physiology
... representing 3 stages of adolescent development, early adolescent (EA, p28-p35), Mid-adolescent (MA, p42-p49) and adult (p63-p70), were placed in the cages of aggressive Long-Evans retired breeder rats daily for 7 days ...
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The Effect of Acute Intra Locus Coeruleus (LC) Microinfusion of Bupropion on Formalin-Induced Pain Behavior in Rat
... The Locus Coeruleus as A5, A6 aminergic cell group is a major source of noradrenergic projections to the dorsal horn and has a well-established role in pain modulation ...
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An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development
... In a survey of 2332 human brains aged from 1 to 100, Braak and colleagues reported that the first evidence of soluble abnormal or hyperphosphorylated tau, which ap- pears later in association with the cortical tangles of ...
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cocaine, locus coeruleus, norepinephrine, novelty
... Rats were given 14 days (days 2–15) of binge pattern cocaine exposure (three injections of 15 mg/kg of cocaine per day, timed 1 hr apart) or injections of isovolumetric saline, then giv[r] ...
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Opiate Withdrawal and the Rat Locus Coeruleus: Behavioral, Electrophysiological, and Biochemical Correlates
... Previous studies have shown that chronic, but not acute, treat- ment of rats with morphine results in 45% and 55-60% in- creases, respectively, in levels of adenylate cycla[r] ...
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