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The M2 isoform of pyruvate kinase

Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro

Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro

... for the treatment of cancer. To carry out the PKM2-targeting tumor treatment is a research direction of highly potential val- ue. Nevertheless, a question of whether PKM2 affects the che- motherapy sensitivity has not ...

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension

... ATP. Pyruvate kinase catalyzes the final step in glycolysis by transferring the phosphate from phosphoenolpyruvate (PEP) to ADP, thereby generating pyruvate and ATP ...The M2 isoform of ...

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Evaluation of tumor M2 pyruvate kinase (Tumor M2 PK) as a biomarker for pancreatic cancer

Evaluation of tumor M2 pyruvate kinase (Tumor M2 PK) as a biomarker for pancreatic cancer

... Tumor M2-PK as a potential marker of prognosis in patients with pancreatic and peri-ampullary ...dimeric M2 isoform detected by the assay is overexpressed in cancer, the hypothesis that patients with ...

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Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

... The conversion of precancerous lesions to full-fledged cancers requires the affected cells to surpass certain rate-limiting steps. We recently showed that activation of HRAS proto-oncogene in urothelial cells of ...

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Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

... PKM2 isoform expression in cancer cells overexpressing c-Myc ...protein kinase that regulates cell growth, cell survival, and protein synthesis, also stimulates PKM2 expression through activation of HIF-1 ...

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Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread

... Pyruvate kinase (PK) controls the final and rate-limiting reaction of ...PKM1 isoform, tumor cells frequently switch to PKM2 expression [13, ...

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Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis

Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis

... 27]. Pyruvate kinase (PK) is the enzyme that catalyzes the final step in glycolysis, converting phos- phoenolpyruvate (PEP) to pyruvate ...of pyruvate kinase exist: type-R and type-L ...

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A systematic review and meta analysis of the diagnostic accuracy of pyruvate kinase M2 isoenzymatic assay in diagnosing colorectal cancer

A systematic review and meta analysis of the diagnostic accuracy of pyruvate kinase M2 isoenzymatic assay in diagnosing colorectal cancer

... tumour M2-PK and tumour stage [15]. Our results show M2-PK faecal assays to have a sensitivity and specificity of 79% and 80%, respectively, at a cutoff value of 4 units/μl, giving a higher sensitivity than ...

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Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma

Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma

... Pyruvate kinase M2 (PKM2) contributes to the Warburg effect, a hallmark of cancer. We showed that PKM2 levels were correlated with overall survival (hazard ration = 1.675, 95% confidence interval: ...

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Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells

<p>Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells</p>

... Protein expression levels were examined by Western blotting. 22 Total protein was separated from cells or tissues using RIPA lysis buffer (Beyotime Institute of Biotechnology, Shanghai, China) supplemented with ...

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Complex role of HIF in cancer: the known, the unknown, and the unexpected

Complex role of HIF in cancer: the known, the unknown, and the unexpected

... tyrosine kinase-mediated activation of the PI3K-AKT- mTOR pathway seems essential in orchestrating cellular biosynthesis of nucleotides, amino acids, and lipids that involves multiple pathways including HIF-1 α ...

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Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2

Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2

... that leptin could promote EMT in breast cancer cells [20], and IL-8 was one of the key molecules which affected leptin-mediated EMT. To explore other key regulatory molecules that are involved in leptin-induced EMT of ...

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Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells

Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells

... 0.73±0.11, P=0.032). (D) A549 cells were transfected with HA-tagged PKM2-WT or K336R. After 24 h of transfection, the cells were replated into appropriate plates for analysis of basal oxygen consumption rate by a ...

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Huhs1015 reduces pkm2 protein due to autophagic degradation in gastric  cancer cells

Huhs1015 reduces pkm2 protein due to autophagic degradation in gastric cancer cells

... Pyruvate kinase generates ATP when phosphoenolpyruvate is converted to ...by pyruvate kinase is independent from oxygen supply, allowing survival of the organs under hypoxic conditions as seen ...

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Pyruvate kinase and the "high ATP syndrome"

Pyruvate kinase and the "high ATP syndrome"

... The pyruvate kinase activity was specifically increased (about twice the normal ...the pyruvate kinase activity was found to be increased in all Percoll ...fractions. Pyruvate ...

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Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

... The effect of PKM2 expression on the clinicopathological features in different digestive tumors was further analyzed and listed in Table 2. When focusing on GC and biliary cancer, a s[r] ...

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Original Article Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer

Original Article Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer

... About 80 years ago, a German biochemist Otto Warburg who got the Nobel Prize found that cancer cells obtain most of their energy by gly- colysis even in the presence of adequate oxy- gen [1]. This concept was called ...

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Original Article Aconitate 2 (ACO2) and pyruvate kinase M2 (PKM2) are good predictors of human sperm freezability

Original Article Aconitate 2 (ACO2) and pyruvate kinase M2 (PKM2) are good predictors of human sperm freezability

... and pyruvate kinase M2 (PKM2) are closely related to glucose metabo- lism and our previous study showed these two proteins had marked differences between the fresh and freeze-thawed sperm samples ...

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Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2

<p>Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2</p>

... Background: Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenol- pyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell ...of ...

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Original Article Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value

Original Article Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value

... Pyruvate kinase (PK) consists of four isoforms, PKL, PKR, PKM1 and PKM2 [19, 20]. PKM1 and PKM2 are derived from the alternative splicing of PKM pre-mRNA gene by the inclusion of exon 10 [21]. PKM2 is ...

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