The mechanism of eukaryotic cap-dependent translation
Cap-Independent Translation Conferred by the 5′ Leader of Tobacco Etch Virus Is Eukaryotic Initiation Factor 4G Dependent
... of cap-independent translation in ...enhance cap-independent translation in vivo but not in vitro (31), suggesting the possibility that a factor required for the function of the TEV leader ...
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Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism
... of translation by RNA that enters across the cytoplasmic membrane ...this mechanism, the cell is able to inhibit the translation of invading mRNAs by ⬎10-fold while preserving the translation ...
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Cap dependent translation contributes to resistance of myeloma cells to bortezomib
... the eukaryotic translation initiation factor 4F (eIF4F) complex on the 5' m7 GpppN cap structure of ...the cap binding protein eIF4E , the scaffold protein eIF4G and the ATP- dependent ...
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Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
... novel mechanism to effectively recruit trans- lation initiation factors under conditions in which these factors are limiting within the ...cellular cap-dependent translation ...cellular ...
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A Possible Mechanism of DNA to DNA Transcription in Eukaryotic Cells: Endonuclease Dependent Transcript Cutout
... endonuclease dependent transcript cutout is not only decided by the restriction sites, it is also restricted by DNA modifications, such as DNA methylation ...ase dependent transcript cutout to sort them ...
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Activation of Cap-Dependent Translation by Mucosal Human Papillomavirus E6 Proteins Is Dependent on the Integrity of the LXXLL Binding Motif
... enhance cap-dependent trans- lation likely reflects a common requirement during the viral life ...increase cap-dependent ...and cap-dependent translation suggests that ...
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HIV- 1 Protease Inhibits Cap- and Poly(A)-Dependent Translation upon elF4GI and PABP Cleavage
... the translation mixture and protein synthesis was analyzed by autoradiography 1h later (Figure ...6E). Translation of (+/+) luc mRNA was partially inhibited after incubation with 5 ng HIV-1 PR, and was ...
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Mechanism of cap independent translation by long distance kissing stem loop interactions in plant viral RNAs
... differential translation of the BYDV gRNA and sgRNA1 under certain ...powerful mechanism for protein expression under cellular mRNA ...of translation of the gRNA to a greater extent that sgRNA1 ...
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The Cap-Binding Translation Initiation Factor, eIF4E, Binds a Pseudoknot in a Viral Cap-Independent Translation Element
... SUMMARY Eukaryotic initiation factor eIF4E performs a key early step in translation by specifically recognizing the m 7 GpppN cap structure at the 5 0 end of cellular ...0 cap and thus bypass ...
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Investigating the role of SUMOylation of eukaryotic translation initiation factors
... on translation have been studied over many years; however, the role of phosphorylation in modulating the activity of the protein is still not completely understood, although enhanced levels of eIF4E ...
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Transcription-Coupled Translation Control of AML1/RUNX1 Is Mediated by Cap- and Internal Ribosome Entry Site-Dependent Mechanisms
... as translation regulators in ...mediates cap-dependent translation whereas the P-UTR mediates cap-independent translation and contains a functional internal ribosome entry site ...
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<p>INPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation</p>
... Inositol polyphosphate 4-phosphatase type II (INPP4B) is an inositol polyphosphate phosphatase that has the abil- ity to hydrolyze Phosphatidylinositol 3,4-bisphosphate [PtdIns-3,4-P2] to generate PtdIns-3-P. Since ...
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A Viral Noncoding RNA Generated by cis-Element-Mediated Protection against 5′→3′ RNA Decay Represses both Cap-Independent and Cap-Dependent Translation
... Possible functions of SR1f in RCNMV infection. SR1f started to accumulate later than the genomic and CP sgRNAs in RCNMV-infected BY-2 protoplasts. This suggests a possible role for SR1f in the later stage of virus ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... nebusch 1994). These combined results suggested to in gene dosage requirements for IMT raises the possibil- us that gcd11-K250R strains might exhibit a reduced ity that eIF2B provides a function, in addition to nucleo- ...
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The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner
... cell translation factor, eukaryotic initiation factor 4E (eIF-4E) in infected and transfected ...this translation factor led us to investigate whether Z could modulate host cell ...a mechanism ...
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The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases
... inhibit cap-dependent translation through cleav- age of the translation initiation factor eIF4G without affecting IRES-driven translation with mRNAs having the 5⬘ leader of ...stage, ...
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Cap-Independent Translation Mechanism of Red Clover Necrotic Mosaic Virus RNA2 Differs from That of RNA1 and Is Linked to RNA Replication
... no cap structure at the 5 ⴕ end and no poly(A) tail at the 3ⴕ ...for cap-independent translation. In this study, we investigated a cap-independent translational mechanism of RNA2 using ...
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Chapter 2 Mechanism of Translation in Eukaryotes
... Initiation of protein synthesis involves five basic steps, which will be described in further detail: (1) mRNA bind- ing by the eIF4F cap-binding complex; (2) 43S preinitiation complex [r] ...
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Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation.
... 25. Kahvejian, A., G. Roy, and N. Sonenberg. 2001. The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation. Cold Spring Harb. Symp. Quant. Biol. 66:293–300. 26. Karim, M. ...
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Translation initiation events on structured eukaryotic mRNAs generate gene expression noise
... inhibit translation initiation when inserted into an mRNA 5 untranslated region, but also generate ...of eukaryotic genes. Our findings suggest a mechanism for posttranscriptional noise generation ...
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