The natural killer cells
Recognition of Vaccinia Virus-Infected Cells by Human Natural Killer Cells Depends on Natural Cytotoxicity Receptors
... Natural killer cells are important components of the im- mune responses to many viruses, yet with the exception of NK recognition of cytomegalovirus-infected cells (17, 25), the mechanisms ...
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Transplantation and innate immunity: the lesson of natural killer cells
... Natural killer cells have been demonstrated to play a major role in mediating an anti-leukemia effect in patients given a T-cell depleted allogeneic hematopoietic stem cell transplantation from an ...
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Natural killer cells and natural killer T cells in Lyme arthritis
... NK cells, patients with antibiotic-responsive arthritis had higher frequencies of iNKT cells in SF than PB, but these cells were often absent in SF in patients with antibiotic-refractory ...iNKT ...
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Activation of natural killer cells by rituximab in granulomatosis with polyangiitis
... live cells were roughly gated based on forward and sideward scatter (FSC, ...positive cells were determined as “ dead ” and remaining cells as “ live ” ...apoptotic cells which would be ...
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Uterine natural killer cells as modulators of the maternal fetal vasculature
... Despite belonging to the immune system, uNK cells’ primary contributions to the developing pregnancy are not immune in nature. Rather, uNK cell-secreted cytokines and chemokines communicate with fetal trophoblast ...
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Role of human natural killer cells in health and disease.
... NK cells constitutively express IL-2RP (p75) and, in the presence of IL-2, develop into lymphokine-activated killer (LAK) cells capable of killing a broad array of fresh or cultured tumo[r] ...
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Emerging role of Natural killer cells in oncolytic virotherapy
... stem cells is increasingly used to treat hematological malignancies and nonmalignant ...NK cells are among the first to undergo maturation and to recover, and are believed to play an important role in ...
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Natural killer cells in human autoimmune disorders
... NK cells are granular, innate lymphocytes that do not express rearranged antigen receptors ...NK cells comprise 5 to 15% of the peripheral blood mononuclear cells and are also found in secondary ...
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<p>Preparation of highly activated natural killer cells for advanced lung cancer therapy</p>
... Natural killer (NK) cells are a critical component of the innate immune system and are characterized by their rapid response to and strong cytotoxicity against virus- infected or malignant ...
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Human Uterine Natural Killer Cells but Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection by Secretion of CXCL12
... uNK cells to inhibit HIV is independent of IFN- ␥ ...uNK cells, so that some uNK cell clones are able to mediate CXCL12 production, while others can produce IFN- ␥ ...uNK cells may produce CXCL12 and ...
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Therapeutic Depletion of Natural Killer Cells Controls Persistent Infection
... NK cells seemed to be a safe and effective strategy to enhance immunity during persistent infection, the success of this approach was depen- dent upon the severity of immune ...T cells during LCMV infection ...
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Natural killer cells and regulatory T cells in early pregnancy loss
... immune cells that predominantly populate the pregnant uterus are natural killer (NK) ...these cells are not killers, but rather provide a microenviron- ment that is pregnancy compatible and ...
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Herpesvirus Evasion of Natural Killer Cells
... An MHC-I-like MCMV protein that has been confirmed to interact with MHC-I- binding NK cell receptors, but with various consequences, is m157. In 2002, Arase and colleagues reported that, depending on the mouse strain, ...
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Natural killer cells and autoimmunity
... NK cells in promoting allergen-induced airway inflammation ...NK cells after the primary immunization did not impact development of EAE ...NK cells may be most influential at the initiation of the ...
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Natural Killer Cells and Antifungal Host Response
... NK CELLS Although NK cells are able to kill their target by a variety of dif- ferent mechanisms, NK cells primarily exhibit cytotoxicity through release of their granule content, including perforin, ...
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Biomarkers in immune checkpoint inhibition therapy for cancer patients: what is the role of lymphocyte subsets and PD1/PD-L1?
... bright, natural killer; CD56 dim NK: cluster of differentiation-56 dim, natural killer; CD8+ cells: cluster of differentiation-8 positive cells; CD80: cluster of ...
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Adult cancer related hemophagocytic lymphohistiocytosis – a challenging diagnosis: a case report
... The performance of diagnostic criteria, studied in the pediatric population, is yet to be validated in the adult population. Some of the criteria include cytopenias and organomegaly that are inherent features to ...
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Immunity Overview
... Natural Killer Cells perforate cells release perforin protein. insert into membrane of target cell[r] ...
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Natural Killer Cell Immunodeficiency in Siblings: Defective Killing in the Absence of Natural Killer Cytotoxic Factor Activity in Natural Killer and Lymphokine-Activated Killer Cytotoxicities
... Natural killer cells play important roles in the defense against tumor growth and viral infections.’ In the cytolytic event, natural killer cells first nec- ognize and bind to a target c[r] ...
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<p>A Review of MicroRNA in Uveal Melanoma</p>
... stem cells (CSCs) refer to a class of special cancer cells, which are similar to normal stem ...UM cells were more sensitive to NK cell ...+ cells isolated from fi ve UM ...+ cells, ...
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