This 6-year plan aimed to ensure that by Year 6 the NICE Guidelines were being delivered throughout the country. The method was a new service for which most of the staff would have to receive a year’s training on top of whatever mental health training they already had. The service would need roughly 8,000 therapists, of whom 6,000 would have to be trained. In addition there should be employment support workers (1 for every 8 therapists) to help people stay in work or regain employment if they had lost it 20 . The programme has gone remarkably well and has been continued by the present government. Recovery rates are now approaching 50 per cent and are improv- ing as more and more of the therapists become experienced and fewer are trainees.
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The emergence of immunotherapy in NSCLC has changed the landscape of management of this deadly disease, offering a potential for durable response and survival. The efficacy and good safety profile of immune checkpoint inhibitors have made them a major breakthrough in cancer treatment. Efforts are underway to further define new indications for PD-1/PD-L1 inhibitors in frontline, whether used as single agent, or in combination with other antineoplastic agents, in adjuvant and maintenance settings. Whereas CTLA-4 inhibitors have a limited role when used as monotherapy, integrating their use in combination with other agents will likely further expand their indication in the future.
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The remarkable achievements in human genetics over the years have been due to technological advances in gene mapping and in statistical methods that relate genetic variants to disease. Nearly every Mendelian genetic disorder has now been mapped to a specific gene or set of genes, but these discoveries have been limited to high-risk, vari- ant alleles that segregate in rare families. With a working draft of the human genome now in hand, the availability of high-throughput genotyping, a plethora of genetic markers, and the development of new analytical methods, scientists are now turning their attention to common complex disorders such as diabetes, obesity, hypertension, and Alzheimer disease. In this issue, the JCI provides readers with a series dedicated to complex genetic disorders, offering a view of genetic medicine in the 21st century.
The paper presents some smart metering features and state of the art. In this paper we discussed the smart metering system architecture as well as the deployment of the smart metering system. In this paper good level of application possibility has been proposed, which makes these meters useful not only for the utility but also for the consumers and though encouraging the energy saving in economical factor as well. We have also discussed the ways of remote transmission of consumption data. We have presented the case that smart grid and smart metering system is a new frontier of communication research. It poses many unique challenges and opportunity, i.e. Interoperability, /scalability, security, and data management. The success of future smart grid depends on communication infrastructure of the grid, devices and the enabling services.
At the theory level, we see research on Africa as helping to advance the theory of strategy (George, 2015), in the same way that the large number of studies published over the past few decades on emerging economies like China and India has produced some significant advances in the theory of strategic management, management more broadly, and international business, without necessarily producing any radically new theories as yet. That body of research has made global strategy scholars rethink the usefulness of existing theories, for instance the notion that is central to OLI theory that investments ought to flow from develop to less developed economies, and never the other way around (Hennart, 2012). This research has also firmly put (back) on the agenda the importance of the institutional environment for firm strategies, for instance in terms of how institutional voids affect diversification choices (Khanna and Palepu, 2000). Research on Africa, similarly, might lead us to reconsider whether our current set of predictor variables of firms’ strategies is sufficient and how the institutional environment could moderate or mediate the relationship between firm strategies and
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Kennedy’s success in the debate launched a new era in American politics: the television age. As journalist Russell Baker, who covered the Nixon campaign, said, “That night, image replaced the printed word as the natural language of politics.” KENNEDY AND CIVIL RIGHTS A second major event of the campaign took place in October. Police in Atlanta, Georgia, arrested the Reverend Martin Luther King, Jr., and 33 other African-American demonstrators for sitting at a segregated lunch counter. Although the other demonstrators were released, King was sentenced to months of hard labor—officially for a minor traffic violation. The Eisenhower administration refused to intervene, and Nixon took no public position.
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The technology discussed in this article was primarily developed for fundamental research and designed to meet the needs of researchers working in the field of solid-state quantum engineering. Widespread usage of quantum computers is still decades away. An obvious question is therefore whether there are any current real-world applications of single-microwave-photon technology? As with any new technology, it is difficult to predict the impact. The first users will likely be scientists working in e.g. radio astronomy and other areas where the extra overhead in terms of cost and equipment can be tolerated if it leads to significantly higher performance. Technologies such as the paramp —which is essentially just a very good microwave amplifier— are also likely to find applications in demanding areas such as space communications. Another area that will benefit from this technology is precision metrology. The quantum nature of this technology being an advantage since it gives direct connection to the primary standards of the international system of units; this would be especially true if sources and detectors become available with efficiencies high enough to allow for direct microwave photon detection.
This type of gentrification, which we refer to here as retail gentrification, has tended to be analysed as part of a process of residential gentrification (Davidson and Lees 2010:406) and only occasionally as part of what Bridge and Dowling (2001:95) call the “retail landscapes of gentrification”. The most thoroughgoing analysis of the process of retail gentrification is probably that undertaken by Sharon Zukin in New York, principally within Brooklyn. In describing the process whereby the tastes of gentrifiers are expressed in terms of consumption that finds its berth in retail outlets, she warns of the consequences of “shopping for authenticity” (Zukin 2008:745). The quest for authenticity, expressed through consumption (of place as of commodities), leads ineluctably to gentrification. A process of “boutiquing” takes place, in which chain stores transform neighbourhoods, displacing in the process local stores, with government failing to protect them despite their importance to long- time residents (Zukin et al. 2009). In Europe, retail gentrification has been observed in Barcelona, in a project of urban regeneration involving a traditional market, but the city authorities there retained half of the retail outlets in a regenerated part of the Old City at affordable rents (Pascual-Molinas and Ribera-Fumaz 2009). More generally, Spanish markets have remained relatively healthy, but often only through compromises such as incorporating supermarkets or promoting their “authenticity” for touristic purposes (Medina and Alvarez 2009).
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As a new type of competing endogenous RNA (ceRNA) that is widely believed to decoy relevant microRNAs (miR- NAs), circRNAs can impact the bio-functions of miRNAs and thus play an important role in the regulation of miRNA target genes. Compared with other ceRNAs, circRNA has a far better ability to bind miRNAs; thus, it is also called a “super sponge”. This is best illustrated with the example of circular RNA sponge for miR-7 (ciRS-7), which sponges miR-7 efficiently with over 70 miR-7 binding sites [21, 22]. A high level of endogenous interactivity between them could be observed in the mouse brain, especially in the hip- pocampal and neocortical neurons . Ectopic expression of human ciRS-7 mimicked the phenotype caused by knockdown of miR-7, indicating that ciRS-7 can act as a sponge . Having a strong resistance to instability medi- ated by miRNA, it becomes a useful inhibitor of miR-7 ac- tivities, and the transcript levels of miR-7 targets are increased [21, 22]. Another RNA circle, originating at sex- determining region Y (SRY), is composed of 16 binding sites of miR-138, and it functions as the sponge of miR-138, thereby upregulating the expression of miR-138 target genes [21, 23].
Exports to Asia have increased, especially to Japan and a growing market in Hong Kong, Russia (although a ban on US beef was initiated in February 2013), Egypt, Vietnam, and Turkey. This is a substantial development considering that export destinations in 2007 consisted primarily of five countries - Canada, Mexico, Russia, South Korea, and Japan. Furthermore, with tight global supplies and an increasing volume of Australian exports going to China, exports will continue to outpace imports for the foreseeable future and the US will remain competitive with Brazil and other major beef exporting countries. The Brazilian market has also seen great improvements in growth and productivity. Several new markets are now open to Brazil. In addition to main export destinations including Russia, Hong Kong, the EU, and Egypt, beef is now exported from Brazil into Venezuela, Chile, and Iran. Jordan, Turkey, and Congo are also expected to increase beef imports from Brazil and countries including China and Saudi Arabia, which banned imports because of a BSE episode, are expected to resume imports in 2014 (USDA Brazil Annual, 2013).
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The widespread use of automated cars can conceivably generate substantial impacts across a continuum of domains, which Milakis et al. (2017: 325) have classified in three stages: first order (traffic, travel cost, and travel choices); second order (vehicle ownership and sharing, location choices and land use, and transport infrastructure); and third order (energy consumption, air pollution, safety, social equity, economy, and public health). While the extent and exact nature of these changes are yet to unfold, it is clear that they will create new conditions that will require economic actors to adapt, particularly those in the business of making, selling, buying, or providing services through cars.
It is commonly believed that the main discovery of Large Hadron Collider (LHC) is the Higgs boson. However, much more important is not the fact of the Higgs boson existence but where it does exist. To our view, the most important finding of LHC is the fact that Higgs boson and top quark masses correspond to metastability region of the SM vacuum , see Fig.1. The ideas around that has been discussed for decades by many authors, notably by I. V. Krive, A. D. Linde, N. Cabibbo, L. Maiani, G. Parisi, R. Petronzio, M.Lindner, H.B.Nielsen, C.Froggatt, J. Elias-Miro, J. R. Espinosa, G. F. Giudice, G. Isidori, A. Riotto, A. Strumia, J. R. Espinosa, M. Quiros, G.Altarelli. It is very suggestive that historically the things went the other way around: the Higgs boson and top quark masses were predicted in the paper by C.Froggatt and H.B.Nielsen  back in 1995 assuming the SM vacuum is metastable (in the framework of the so called "multiple point principle"). The crucial assumption for this prediction to be credible is the absence of new (heavy) degrees of freedom which are non- singlets with respect to the SM interactions. In other words, this is a strong indication to no New Physics up to the Planck scale.
Here the twisted sheets of metal and bent letters are rendered in soft sheets of vinyl coated fabric, painstakingly and precisely stitched together with a domestic sewing machine. Soft, friendly, domestic, the work reduces the building and its demolition to innocuous mani- festations of a longer term project: the commercial, entrepreneurial one of the empire of money and hope built in the middle of nowhere. Whether a building or a ruin, the physical manifestation of the moment of New Frontier becomes irrelevant, as long as its name and the mirage (indeed the name of another famous casino-hotel in Las Vegas) that goes with it remain. Fasnacht’s New Frontier thus doubly plays on the name of the casino-hotel: not only on the recognisability of the casino’s sign, but also as a reference to the way in which the establishment itself has always played on the ambiguous associations of its name. The original name of the Frontier, Pair-O-Dice, painted gambling as heavenly alluring; the Hotel Last Frontier that followed played on the myth of both its location and use; the New added at the time of its expansion to contrast inevitable obsolescence, was eventually replaced by Old to claim an established heritage in the short time of the Strip city by realigning it with the myth of the West; and so on.
For all interactions between RNA and its partners, a deep understanding of biological significance requires analyses of association and dissociation on a relevant time scale, either in vitro or in the cell. It is likely that standard in vitro techniques will not be sufficient to capture the full picture of what is happening in the cell. Events at this scale are very fast and new methods in kinetics will be needed to produce a meaningful under- standing of the system. Key questions in RNA regulation revolve around where and when within the cell specific events occur. One promising approach is time-resolved intracellular imaging. This involves in vivo fluorescent tagging of RNA. There is much room for innovation in this area, with respect to the development of new fluo- rescent tags that do not interfere with the fundamental properties of the RNA, methods that improve time reso- lution on single molecules, and “multiplexing” so that many different molecules can be observed in different colours simultaneously. Such approaches can provide important information on the dynamics and kinetics of RNA transport and association with proteins.
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owing to the hybridity of that discourse, has been vociferously rejected by Craig S. Womack. Dedicating the entire opening chapter of Reasoning Together to reviewing book-length Native American criticism, Womack argues that the new American Indian (Literary) Nationalist theory/criticism developing in the US marks a major departure from the breakthrough literary production and criticism of, among others, Louis Owens, and Gerald Vizenor, writing in the latter half of the twentieth century. While Womack is respectful of their contribution, he notes that the theoretical focus of these critics, with their cosmopolitan use of both Native and non-Native critical theory, would perhaps be better contextualised as an introduction to Native American literature and how it has been studied over the past forty years or so, than a reflection of the current state and direction of criticism produced by Native Americans. This, he claims, has to some extent led to the problematic academic fixation with supposedly canonical themes that has not kept pace with new criticism or even contemporary Native American literary production, and instead tends to return to the same landmark authors such as Momaday, Silko, Owens, and Vizenor. Pulitano’s thesis is rejected as asserting a reading of hybridity that, in Womack’s view, directly contradicts the separatist position where rather than existing as hybrid, composite peoples, many Indigenous cultures possess clear ideas as to their distinct national character, cultural heritage and identity that are separate and distinct from European cultural influences. In American Indian Literary Nationalism Weaver, Warrior and Womack again challenge the veracity of Pulitano’s thesis, illustrating the extreme contentiousness of this theoretical positioning. 346
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Teledentistry is an emerging mode of practice which promises immense potential in fields of clinical practice as well as public health delivery. Even though considered new, teledentistry has been around since the 1990’s. Like many other health providers dentists are literally tied down to their chairs when it comes to the matter of distance. Teledentistry eliminates that barrier and provides for an even smoother practice environment. Technology is making things possible that were unimaginable a decade ago. Teledentistry has the potential to meet the care needs of the underserved and under reached people of our country and can also contribute towards increasing the quality of our present education system. There also remains a large reservoir of untapped potential with teledentistry in the field of clinical practice. But are we utilizing this opportunity to the fullest? This paper analyses the present state of teledentistry and tries to draw a comparison with the state of telemedicine in India.
The composition of propolis is guided by the phyto- geographic characteristics of beehive surroundings , see also Table 1. Seasonal variations occurring within the same place has been described. Some authors have also reported variations among samples collected in the same area but by different Apis mellifera subspecies . Propolis collected from many countries (such as China, Korea, Croatia, New Zealand, and Africa) [15–18] showed chemical composition similar to poplar. In fact, poplar tree is a typical tree in Europe and is used to name the common type of propolis. Therefore, the current opinion is that bees collect propolis from resins of poplars and co- nifers. This propolis is characterized by high level of flavo- nones, flavones, low phenolic acids, and their esters.
From the public’s point of view, this may be one of the main reasons why journalists fall short of their high- held principles. According to a survey by the Pew Research Center (2009), the public’s assessment of the accuracy of news stories is currently at its lowest level in the United States. Just 29% of Americans say that news organizations generally get the facts straight. Opinion surveys on the performance and credibility of the media are similar (BBC, Reuters & Media Centre Poll, 2006; Pew Research Center for the People and the Press, 2010). Even if media criticism is all but new, throughout the last decade opinion polls and media scholars painted a depressing picture when it comes to credibility and trust in traditional news outlets. On top of that, critical episodes such as the case of Jayson Blair at the New York Times or the controversy about U.S. author Mike Daisey and his partially fabricated story about Apple’s supply chain in China have not
The acceleration of change necessitates strategies to control time, considered not only as a variable that influences the temporal evolution of phenomena but as one that directly influences phenomena itself. This study tries to present the logic of time compression and time to market, as well as the main instruments for the formulation of time-based strate- gies, not only by observing how the value of time is perceived as a contraction of production and distribution lead times but also by considering the choice of the most opportune moment to start a business and introduce (or withdraw) a new product. Starting from a discussion of time-based competition managerial approaches, this study develops a theoretical framework showing different time-based methodologies (JIT, MRP, OPT, FMS, PERT, HSM) that help management to adopt time-based strategies. It also puts forward a taxonomy of time-based strategies as well as a logical strategic path to time value.
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15. Haneder S, Kettnaker P, Konstandin S, Morelli JN, Schad LR, Schoenberg SO, et al. Quantitative in vivo 23Na MR imaging of the healthy human kidney: determination of physiological ranges at 3.0T with comparison to DWI and BOLD. Magma (New York, NY). 2013 Dec;26(6):501-9. PubMed PMID: 23475308. Epub 2013/03/12. eng. 16. Haneder S, Michaely HJ, Schoenberg SO, Konstandin S, Schad LR, Siebenlist K, et al. Assessment of renal function after conformal radiotherapy and intensity-modulated radiotherapy by functional 1H-MRI and 23Na- MRI. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft [et al]. 2012 Dec;188(12):1146- 54. PubMed PMID: 23111472. Epub 2012/11/01. eng.
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