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The Penicillin Binding Proteins

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials.

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials.

... It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex machineries. Both activities are ...

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Eliminating a Set of four penicillin binding proteins triggers the Rcs phosphorelay and Cpx stress responses in escherichia coli

Eliminating a Set of four penicillin binding proteins triggers the Rcs phosphorelay and Cpx stress responses in escherichia coli

... Penicillin binding proteins (PBPs) are responsible for synthesizing and modifying the bacterial cell wall, and in Escherichia coli the loss of several nonessential low-molecular-weight PBPs gives ...

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Single nucleotide polymorphisms in genes encoding penicillin binding proteins in β lactamase negative ampicillin resistant Haemophilus influenzae in Japan

Single nucleotide polymorphisms in genes encoding penicillin binding proteins in β lactamase negative ampicillin resistant Haemophilus influenzae in Japan

... the penicillin-binding proteins, and we reconfirmed that susceptibility to β-lactam antibiotics was mainly defined by previously reported SNPs in the ftsI ...

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Characterization of nutritionally variant streptococci by biochemical tests and penicillin binding proteins

Characterization of nutritionally variant streptococci by biochemical tests and penicillin binding proteins

... A comparative study of 60 strains of nutritionally variant streptococci (NVS) with 34 strains of Streptococcus mitis and 37 strains of Streptococcus sanguis Il showed the presence of a r[r] ...

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Whole genome sequencing of penicillin resistant Streptococcus pneumoniae reveals mutations in penicillin binding proteins and in a putative iron permease

Whole genome sequencing of penicillin resistant Streptococcus pneumoniae reveals mutations in penicillin binding proteins and in a putative iron permease

... to penicillin in ...to penicillin, the introduction of altered versions of PBPs into a penicillin-susceptible strain by sequential transformation led to strains with a minimal increase in resistance, ...

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Analysis of amino acid motif of penicillin binding proteins 1a, 2b, and 2x in invasive Streptococcus pneumoniae nonsusceptible to penicillin isolated from pediatric patients in Casablanca, Morocco

Analysis of amino acid motif of penicillin binding proteins 1a, 2b, and 2x in invasive Streptococcus pneumoniae nonsusceptible to penicillin isolated from pediatric patients in Casablanca, Morocco

... genes, suggesting a high frequency recombination or point mutations that they undergoes over the time [21]. Conclusions This study constitutes the first investigation of pbp gene alterations in invasive S. pneumoniae ...

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Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

... In conclusion then, the construction of PBP mutant strains ΔPBP4 and ΔLmo441 (Fig. 2) displayed no obvi- ous growth defects in L. monocytogenes, suggesting that the individual PBPs are most likely not essential for ...

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Characterization of the Bacillus subtilis Penicillin Binding Protein PBP4

Characterization of the Bacillus subtilis Penicillin Binding Protein PBP4

... for Penicillin- Binding Proteins (PBPs) including pbpE which is translated into PBP4*, a pro- tein of 451 amino acids (NCBI accession number: ...

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Penicillin binding protein inactivation by human neutrophil myeloperoxidase

Penicillin binding protein inactivation by human neutrophil myeloperoxidase

... (penicillin-binding proteins, PBPs) found in all eubacteria, that covalently bind beta-lactam antibiotics to their active sites with loss of enzymatic ...of penicillin binding by PBPs, ...

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The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.

The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.

... Abstract. Penicillin-binding proteins (PBPs) are mem- brane proteins involved in the final stages of peptidogly- can synthesis and represent the targets of b-lactam an- ...

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Variation in penicillin binding protein patterns of penicillin resistant clinical isolates of pneumococci

Variation in penicillin binding protein patterns of penicillin resistant clinical isolates of pneumococci

... These two resistant strains had a common PBP pattern that was completely different from the PBP pattern of the penicillin-susceptible laboratory strain in the number of PBPs detectable b[r] ...

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Oxygen-Binding Proteins

Oxygen-Binding Proteins

... Changes Induced by O 2 Binding • O 2 binding rearranges electrons within Fe +2 making it more compact so that it fits snugly within the plane of porphyrin. • Since Fe is bound to histidine of the globin ...

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Prediction of DNA-Binding Proteins and their Binding Sites

Prediction of DNA-Binding Proteins and their Binding Sites

... DNA-binding proteins play an important role in various essential biological processes such as DNA replication, recombination, repair, gene transcription, and ...DNA-binding proteins and the ...

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CaMELS : In silicoprediction of calmodulin binding proteins and their binding sites

CaMELS : In silicoprediction of calmodulin binding proteins and their binding sites

... ) binding protein that is highly conserved across all ...by binding various targets in the cell including a large number of enzymes, ion channels and other ...CaM binding proteins are mostly ...

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GraphProt: modeling binding preferences of RNA binding proteins

GraphProt: modeling binding preferences of RNA binding proteins

... Abbreviations APR, average precision; AUROC, area under the receiver operating characteristic curve; CDS, coding sequence; CLIP, cross-linking and immunoprecipitation; dsRBP, double-stranded RNA-binding protein; ...

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Development of an Immunochromatographic Strip for Simple Detection of Penicillin-Binding Protein 2′

Development of an Immunochromatographic Strip for Simple Detection of Penicillin-Binding Protein 2′

... Laboratory for Antimicrobial Agents, Kitasato University, 5-9-1 Shirokane, Minato-Ku, Tokyo 108-8641, Japan, 1 and Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-Ku, Tokyo 108-8641, ...

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Ligand binding and homology modelling of insect odorant-binding proteins

Ligand binding and homology modelling of insect odorant-binding proteins

... competitive binding assays using N-phenyl-1-naphthylamine as a fluorescence probe are used to study the ligand binding affinity to OBPs (Lescop et ...the binding affinities in connection with ...

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The MTA family proteins as novel histone H3 binding proteins

The MTA family proteins as novel histone H3 binding proteins

... three proteins were mainly detected in the chromatin fraction and the chromatin asso- ciation was resistant to the salt extraction upon to 350 mM ...HSP90 proteins were detected primarily in the ...

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Small GTP-binding proteins (G proteins) are monomeric G

Small GTP-binding proteins (G proteins) are monomeric G

... G proteins, including G q/11 , G i , G 12 , and G 13 , and produces second messengers, such as inositol triphos- phate, diacylglycerol, and reactive oxygen species ...G proteins as essential molecular ...
DNA-binding activity of papillomavirus proteins.

DNA-binding activity of papillomavirus proteins.

... At 200 mM NaCl, the background (DNA-binding activity of E. coli or degraded E6 proteins) is reduced, and at higher (>200 mM) NaCl concentrations, the DNA-binding activity of the HPV6b[r] ...

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