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The Phosphorylation of Tau

Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease

<p>Phosphorylation of Tau and &alpha;-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson&rsquo;s Disease</p>

... protein Tau is a neuronal protein that plays important roles in microtubule assembly and ...phosphor Tau (p-Tau) shows its tendency of aggregation which occurs in Alzheimer disease (AD), Pick disease ...

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Role of GSK3β and PP2A on Regulation of Tau Phosphorylation in Hippocampus and Memory Impairment in ICV STZ Animal Model of Alzheimer’s Disease

Role of GSK3β and PP2A on Regulation of Tau Phosphorylation in Hippocampus and Memory Impairment in ICV STZ Animal Model of Alzheimer’s Disease

... the phosphorylation of tau ...reduced phosphorylation of GSK3 β (p-GSK3 β ) and PP2A in hippocampus and PFC, indicating that GSK3 β and PP2A contributed to regulation of ...of tau and the ...

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Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

... phosphorylated tau is in- creased in neurodegenerative diseases and correlates with the formation of toxic tau aggregates [12, 13, ...in tau phosphorylation cause neuron loss using the ...in ...

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Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain

Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain

... specific, phosphorylation-dependent anti-Tau antibodies: an antibody against phosphorylation sites within Tau’s C-terminal region (pSer396-pSer404) ...against phosphorylation sites near to or ...

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Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn

... serine/threonine phosphorylation sites on tau are predominantly in the central part of the molecule or near the C-terminus, on either side of the microtubule- binding repeats [3], and phosphorylation ...

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Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

... the phosphorylation status of residues S199/S202 in tau in- fluences its binding to fyn-SH3 [6], but the effects of tau phosphorylation at other residues on tau-fyn bind- ing have not ...

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Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS

Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS

... pathologic tau aggregates contain aber- rantly phosphorylated tau with immunoreactivity to both pThr 175 tau and pThr 231 ...oligomeric tau) is consistent with a pivotal role for ...

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Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau

... hyperphosphorylated tau proteins [6]. Tau is a class of microtubule-associated pro- tein ...The tau proteins are normally expressed in neuronal and glial cytoplasm including cell bodies, neur- ites ...

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Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

... hyperphosphorylated tau epitopes is noted with both mutations, hyperphosphorylated tau partitioned to the insoluble fraction in Tau P301L -AAV mice and remained soluble in Tau A152T -AAV ...in ...

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Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

... the tau kinases, glycogen-kinase synthase-3 and cyclin-dependent kinase 5 were also found to occur in Braak stage II-III brain, and these preceded global elevations in tau phosphorylation and the ...

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Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

... Because Tau Y18F was unable to enhance excitotoxicity at high glutamate concentrations, a potential excitopro- tective strategy may be to inhibit phosphorylation of tau by Fyn, a process that appears ...

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The Role of the Tau N-Terminal Phosphatase-Activating Domain and Phosphorylation at Thr175 in the Formation of Tau Cytoplasmic Inclusions

The Role of the Tau N-Terminal Phosphatase-Activating Domain and Phosphorylation at Thr175 in the Formation of Tau Cytoplasmic Inclusions

... protein phosphorylation and structural changes also play a role in regulating the transport of vesicles along axonal processes and the unloading of cargo from kinesin motor ...the tau protein N-terminal PAD ...

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Phosphorylation of tau protein at Thr175 is a toxic event associated with neurodegeneration

Phosphorylation of tau protein at Thr175 is a toxic event associated with neurodegeneration

... of tau protein are encoded by exons 9-12, and consist of imperfectly repeated stretches of 18 highly conserved residues, separated by 13-14 amino acid spacers (Kar et ...4R tau protein promotes microtubule ...

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Understanding Tau phosphorylation in Alzheimer’s disease

Understanding Tau phosphorylation in Alzheimer’s disease

... The tau is known as axonal protein that regulates microtubule-associated (MT) stability and MT- dependent ...The tau protein is a low molecular weight microtubule associated protein ...human tau gene ...

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Modulation of tau phosphorylation by environmental copper

Modulation of tau phosphorylation by environmental copper

... and tau phosphorylation [19]. Whether the effect of copper on tau phosphorylation is independent of the Aβ/copper interaction is yet to be ...

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Tau phosphorylation by GSK-3β promotes tangle-like filament morphology

Tau phosphorylation by GSK-3β promotes tangle-like filament morphology

... of tau filaments from AD brain, polymerization reaction products were fractionated using centrifugation through a discontinuous gradient of ...individual tau filaments from NFT-like bundles of tau ...

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Phosphorylation of The Tau Protein in
Neurodegenerative Disease

Phosphorylation of The Tau Protein in Neurodegenerative Disease

... Protein phosphorylation is a reversible post-translational modification that involves a series of sequence-specific kinases and occurs on specific residues such as serine, threonine, and ...reversible ...

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Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

... anti tau pThr 231 (Thermo Fischer) were used to probe tau in- clusions for the presence of oligomeric tau (T22) and for phosphorylation at Thr 231 .... Tau oligomeric species are cur- ...

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Phosphorylation of different tau sites during progression of Alzheimer’s disease

Phosphorylation of different tau sites during progression of Alzheimer’s disease

... phosphorylated tau (ptau) sites. Here, we investigate total tau and ptau at residues Tyr18, Ser199, Ser202/Thr205, Thr231, Ser262, Ser396, Ser422 as well as amyloid- β plaques in human brain tissue of AD ...

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Salidroside reduces tau hyperphosphorylation via up regulating GSK 3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease

Salidroside reduces tau hyperphosphorylation via up regulating GSK 3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease

... increasing tau phosphorylation occurs early in the development of AD [14, 15], and that Aβ associated clinical cognitive decline is identified only following such elevated tau phosphorylation ...

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