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The Urokinase Plasminogen Activator System

Expression and activity of the urokinase plasminogen activator system in canine primary brain tumors

Expression and activity of the urokinase plasminogen activator system in canine primary brain tumors

... the urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol-anchored protein family member, and the activity of its ligand, urokinase-type plasminogen ...

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Review. The urokinase-type plasminogen activator system and inflammatory joint diseases

Review. The urokinase-type plasminogen activator system and inflammatory joint diseases

... lytic system, several lines of evidence indicate that the interaction of u-PA with u-PAR elicits a complex series of events ranging from chemotaxis and chemoki- nesis (65-70) to cell multiplication (70- 75), ...

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Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells

Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells

... More than a century ago, Armand Trousseau first described an association between cancer and the coagulation system 1,2 . Later it was discovered that tumor cells release procoagulant microvesicles (often referred ...

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Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer

Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer

... which functions as a natural inhibitor of uPA, is the most important factor among fibrinolytic inhibi- tors for the development of vascular diseases and cancer. uPA and PAI-1 do not only have proteolytic characteristics, ...

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Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

... washing three times with TNT wash buffer, sections were exposed to TNB (0.1 M Tris–HCl, pH7.5, contain- ing 0.15 M NaCl, 0.5% Blocking Reagent [PerkinElmer, Waltham, MA, USA]) blocking buffer for 1 h at RT, and were then ...

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Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke

Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke

... 1. Introduction Stroke is defined as an acute neurological dysfunction lasting more than 24 hours, attributed to cerebrovascular aetiology. In general, it is classified into ischaemic and haemorrhagic types. Ischaemic ...

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The plasminogen activator/plasmin system

The plasminogen activator/plasmin system

... Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activa-. tor and urokinase[r] ...

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ORIGINAL ARTICLE. Expression of Urokinase-type Plasminogen Activator and Its Receptor in Keloids

ORIGINAL ARTICLE. Expression of Urokinase-type Plasminogen Activator and Its Receptor in Keloids

... Two plasminogen activator in- hibitors (PAI-1 and PAI-2) help regulate the enzymatic activity of ...uPAR system has not previously been studied in ...

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Preclinical evaluation of a urokinase plasminogen activator receptor-targeted nanoprobe in rhesus monkeys

Preclinical evaluation of a urokinase plasminogen activator receptor-targeted nanoprobe in rhesus monkeys

... More importantly, results of our study show that the blood chemistry variables such as ALT, ALP, BIL-D, and CREA, which are very sensitive to any disease process of the liver 35 or kidney and which can effectively ...

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Molecular and cellular studies of the role of urokinase plasminogen activator in cutaneous wound healing

Molecular and cellular studies of the role of urokinase plasminogen activator in cutaneous wound healing

... the plasminogen activator system is important in cellular m igration and tissue rem ...proteolytic system during wound re- epithelialization (R om er et al, 1996; Bugge et al, 1996a) and it ...

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Urokinase Plasminogen Activator Receptor (uPAR) Targeted Nuclear Imaging and Radionuclide Therapy

Urokinase Plasminogen Activator Receptor (uPAR) Targeted Nuclear Imaging and Radionuclide Therapy

... Urokinase-type plasminogen activator receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored ...uPA/uPAR system, it is desirable to develop non-invasive imaging methods to visualize ...

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Evaluation of diagnostic value of soluble urokinase-type plasminogen activator receptor in sepsis

Evaluation of diagnostic value of soluble urokinase-type plasminogen activator receptor in sepsis

... of plasminogen transformation to plasmin. Two types of plasminogen activators (PA) have been charac- terized; tissue type PA (tPU) and urokinase PA ...cells. Plasminogen activation is ...

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TFRC and ACTB as the best reference genes to quantify Urokinase Plasminogen Activator in breast cancer

TFRC and ACTB as the best reference genes to quantify Urokinase Plasminogen Activator in breast cancer

... Six common housekeeping genes in breast cancer; TFRC, GUSB, GAPDH, ACTB, HPRT1 and RPLP0; were selected and their stability were examined in order to normalize expression of uPA. All primers and probes were designed ...

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Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia

Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia

... the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-residue peptide derived from this protein (u7-peptide), bound the receptor and ...

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Shear stress modulates macrophage induced urokinase plasminogen activator expression in human chondrocytes

Shear stress modulates macrophage induced urokinase plasminogen activator expression in human chondrocytes

... The mechanism by which macrophages regulate uPA gene expression in chondrocytes, however, remains unclear. In our present study, we investigated the molecular mechanisms by which macrophages stimulate uPA expression in ...

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A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of a Reciprocal Activation System Based on a Single Chain Urokinase-Type Plasminogen Activator and Plasminogen

A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of a Reciprocal Activation System Based on a Single Chain Urokinase-Type Plasminogen Activator and Plasminogen

... activation system with a single chain urokinase type plasminogen activator and ...chain urokinase-type plasminogen activator (pro-uPA) activated plasminogen, k cat ...

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A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.

A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.

... vitro system lacks physiologic components that would considerably enhance the kinetics of plasminogen acti- vation, importantly the uPA receptor (10, ...

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Regulation of Lung Injury and Fibrosis by p53-Mediated Changes in Urokinase and Plasminogen Activator Inhibitor-1

Regulation of Lung Injury and Fibrosis by p53-Mediated Changes in Urokinase and Plasminogen Activator Inhibitor-1

... groups, who reported that suppression of uPAR augmented p53, 41,42 indicating intricate links between p53, the uPA fibrinolytic system, and ATII cell viability. p53 is increased in ATII cells in mice after BLM ...

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Coordinated expression of the vitronectin receptor and the urokinase type plasminogen activator receptor in metastatic melanoma cells

Coordinated expression of the vitronectin receptor and the urokinase type plasminogen activator receptor in metastatic melanoma cells

... activator system of ...of urokinase plasminogen activator receptor (uPAR) mRNA and had higher levels of surface bound urokinase plasminogen activator as detected by ...

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Urokinase type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models

Urokinase type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models

... or plasminogen) systemic immune complex-mediated arthritis models are resistant to full disease development [3-5], it could be that synovial u- PA/plasmin is a critical component of an immune com- plex-mediated ...

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