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THIOL PROTEASE INHIBITOR

Purification and characterization of a defective thiol protease inhibitor from the skeletal muscle of mice with hereditary muscular dystrophy.

Purification and characterization of a defective thiol protease inhibitor from the skeletal muscle of mice with hereditary muscular dystrophy.

... for protease inhibitors as modulators of intracellular proteolysis has been recognised, the intracellular function of the molecules involved are not very well ...by protease inhibitors. Thiol ...

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Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus.

Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus.

... Lanes: 1, mock-infected cell extract; 2, FMDV-infected cell extract; 3, extract from cells infected with FMDV in the presence of E-64; 4, in vitro translation programmed with FMDV A12 RN[r] ...

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MW ASSISTED SYNTHESIS AND BIOLOGICAL PREDICTION STUDY OF SOME NEW PYRAZOLE 4 CARBONITRILE DERIVATIVES USING MALONONITRILE

MW ASSISTED SYNTHESIS AND BIOLOGICAL PREDICTION STUDY OF SOME NEW PYRAZOLE 4 CARBONITRILE DERIVATIVES USING MALONONITRILE

... Activity Complement factor D inhibitor ErbB-1 antagonist Aspulvinonedimethylallyltransferase inhibitor Antipsoriatic Thiol protease inhibitor Monodehydroascorbate reductase NADH inhibito[r] ...

9

Molecular and Biochemical Characterization of a Cathepsin B-Like Protease Family Unique to Trypanosoma congolense

Molecular and Biochemical Characterization of a Cathepsin B-Like Protease Family Unique to Trypanosoma congolense

... RNA extraction and RT-PCR analysis. Total RNA was extracted from procy- clic and bloodstream forms of T. congolense IL-3000 using TRIzol reagent (In- vitrogen) according to the manufacturer’s instructions. Total RNA from ...

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Resistance-Associated Loss of Viral Fitness in Human Immunodeficiency Virus Type 1: Phenotypic Analysis  of Protease andgag Coevolution in Protease  Inhibitor-Treated Patients

Resistance-Associated Loss of Viral Fitness in Human Immunodeficiency Virus Type 1: Phenotypic Analysis of Protease andgag Coevolution in Protease Inhibitor-Treated Patients

... To determine the Gag cleavage site sequences of all the pa- tients’ samples, viral RNA was purified from plasma or super- natant of a single-passage peripheral blood lymphocyte infec- tion (patients 116, 125, 129, 131, ...

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Evolution of Human Immunodeficiency Virus Type 1 Protease Genotypes and Phenotypes In Vivo under Selective Pressure of the Protease Inhibitor Ritonavir

Evolution of Human Immunodeficiency Virus Type 1 Protease Genotypes and Phenotypes In Vivo under Selective Pressure of the Protease Inhibitor Ritonavir

... Blood plasma samples. Blood plasma samples were obtained with institutional review board approval unlinked to subject identifiers and as excess tissue sam- ples. The blood plasma samples are from subjects who ...

12

PubMedCentral-PMC4912444.pdf

PubMedCentral-PMC4912444.pdf

... Drug design typically focuses on improving affinity against a single target of interest, typically the wild-type variant of the most common genotype in the case of viral proteases. Indeed, all the HIV-1 PIs have been ...

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Influence of ultrasound and proteolytic enzyme inhibitors on muscle degradation, tenderness, and cooking loss of hens during aging

Influence of ultrasound and proteolytic enzyme inhibitors on muscle degradation, tenderness, and cooking loss of hens during aging

... (B), protease inhibitor cocktail (C), protease inhibitor cocktail and ultrasonic treatment (D), ultra- sonic treatment (E), aprotinin (1 µg/ml), leupeptin (2 mmol/l) and 20% DMSO treatment ...

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Inhibitors of prostaglandin synthesis or cathepsin B prevent muscle wasting due to sepsis in the rat

Inhibitors of prostaglandin synthesis or cathepsin B prevent muscle wasting due to sepsis in the rat

... Cathepsin B activity was selectively elevated early in the course of illness. Luepeptin, a cathepsin B inhibitor, and indomethacin, a prostaglandin synthesis inhibitor, prevented muscle atrophy and impaired ...

5

DIVERSE CLINICAL FUNCTIONS OF SERINE PROTEASE AND ITS INHIBITORS

DIVERSE CLINICAL FUNCTIONS OF SERINE PROTEASE AND ITS INHIBITORS

... a-1-Protease inhibitor deficiency is a genetic disorder of ...a-1-protease inhibitor can leads to prolong and unopposed activity of neutrophil elastase, recent studies reveals that when ...

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Identification of Biased Amino Acid Substitution Patterns in Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Protease Inhibitors

Identification of Biased Amino Acid Substitution Patterns in Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Protease Inhibitors

... idue at each position was used. When a mixture was present in a sequence obtained by direct PCR sequencing, the residue associated with the greatest electrophoretic signal was used. Each control sequence was considered ...

6

Identification of Genotypic Changes in Human Immunodeficiency Virus Protease That Correlate with Reduced Susceptibility to the Protease Inhibitor Lopinavir among Viral Isolates from Protease Inhibitor-Experienced Patients

Identification of Genotypic Changes in Human Immunodeficiency Virus Protease That Correlate with Reduced Susceptibility to the Protease Inhibitor Lopinavir among Viral Isolates from Protease Inhibitor-Experienced Patients

... Identity of specific amino acid changes associated with re- duced susceptibility. Since multiple amino acid substitutions have been observed at many of the amino acid positions in HIV protease, we sought to ...

8

Studies on antibacterial activity and biochemical/biophysical properties of phytocystatin purified from Catharanthus roseus (Madagascar Periwinkle): an evergreen subshrub commonly found in district bijnor (U P )

Studies on antibacterial activity and biochemical/biophysical properties of phytocystatin purified from Catharanthus roseus (Madagascar Periwinkle): an evergreen subshrub commonly found in district bijnor (U P )

... The antibacterial effect was classified as (+), +, ++, or +++ based upon the inhibition zone diameter of 11 - 12 mm, 13 - 14 mm, 15 - 16 mm, 17 mm and more than 17 mm respectively. Results illustrated in Table 2 show ...

6

Modulation of HIV 1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

Modulation of HIV 1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

... In vitro evolution experiments were performed in five- fold for all NC/p1 mutants. For this SupT1 cells (2.0 × 10 6 ) were infected with 250 μl recombinant virus in an initial volume of 1 ml culture medium. After 1 h ...

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Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients

Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients

... The thiol disulfide homeostasis has a vital importance in organism. Thiol disulfide imbalance is an early indicator of oxidative ...unclear. Thiol disulfide homeostasis in these patients has not been ...

7

Protease inhibitors enhance extracellular collagen fibril deposition in human mesenchymal stem cells

Protease inhibitors enhance extracellular collagen fibril deposition in human mesenchymal stem cells

... extracellular protease inhibitor ...lular protease inhibitor, short collagen fibrils were observed ...extracellular protease in- hibitor was observed at 24 h ...extracellular ...

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Metal-sensitive and thermostable trypsin from the crevalle jack (Caranx hippos) pyloric caeca: purification and characterization

Metal-sensitive and thermostable trypsin from the crevalle jack (Caranx hippos) pyloric caeca: purification and characterization

... The Sephadex G-75 chromatograms for trypsin from tambaqui [17], Nile tilapia [1], and spotted goatfish [6] presented profiles analogous to that found for crevalle jack (Figure 1a). A similar method using Sephadex G-100 ...

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Recombinant Cystatin-Like Thiol Proteinase Inhibitor (rCTPI) of Cicer arietinum (Chickpea): A potential source of Bio-pesticide.

Recombinant Cystatin-Like Thiol Proteinase Inhibitor (rCTPI) of Cicer arietinum (Chickpea): A potential source of Bio-pesticide.

... or thiol proteinase inhibitors (TPIs) belonging to the superfamily of evolutionary, structurally and functionally related proteins involved in the inhibition of papain and related cysteine proteinases like ficin ...

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Functional Correlates of Insertion Mutations in the Protease Gene of Human Immunodeficiency Virus Type 1 Isolates from Patients

Functional Correlates of Insertion Mutations in the Protease Gene of Human Immunodeficiency Virus Type 1 Isolates from Patients

... the protease and RT genes of HIV to emerge and to be selected as the predominant isolates during drug treatment (3, 15, 23, ...to protease inhibitors have been single codon substitutions that have resulted ...

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A Biofilm Matrix Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack

A Biofilm Matrix Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack

... In this study, we identified 60 matrix-associated proteins using a noninvasive proteomic approach. We hypothesized that the extracellular matrix selectively retains biochemically active proteins that aid in the protection ...

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