thyroxine binding
PARTIAL THYROXINE-BINDING GLOBULIN DEFICIENCY IN A FAMILY
... : X-Chromosome linked inheritance of thyroxine binding glob- ulin deficiency. : Human thyroxine-binding globulin[r] ...
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FAMILIAL INCREASE IN THE THYROXINE BINDING SITES IN SERUM ALPHA GLOBULIN
... Because the serum protein-bound iodine PBI has been found elevated in euthyroid states associated with an increase of thyroxine-binding capacity of plasma thyroxine-binding a globulin TB[r] ...
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Salicylate induced increases in free triiodothyronine in human serum: Evidence of inhibition of triiodothyronine binding to thyroxine binding globulin and thyroxine binding prealbumin
... demonstrated binding of T 3 to TBPA. The affinity constant for T 3 -TBPA binding appears to be slightly greater than that for albumin-T 3 ...the binding of T 3 (and T 4 ) to TBPA, it can be predicted ...
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Metabolism of thyroxine binding globulin in man Abnormal rate of synthesis in inherited thyroxine binding globulin deficiency and excess
... It has been previously suggested that inherited thyroxine-binding globulin (TBG) abnormalities in man may be due to mutations at a single X-chromosome-linked locus controlling TBG synthesis. However, ...
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Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine binding globulin
... To investigate the role of thyroxine-binding globulin TBG and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine T4 and tri[r] ...
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Effects of Norethandrolone on the Transport and Peripheral Metabolism of Thyroxine in Patients Lacking Thyroxine Binding Globulin: OBSERVATIONS ON THE PHYSIOLOGICAL ROLE OF THYROXINE BINDING PREALBUMIN
... free thyroxine iodine were at the lower end of the normal range ...control thyroxine- turnover study, the thyroxine distribution space was strikingly increased ...of thyroxine turnover ...
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The contribution of thyroxine binding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption
... remove thyroxine (T 4 )-binding prealbumin (TBPA) from serum completely without affecting the T 4 -binding activity of thyroxine-binding globulin (TBG) or the concentration of the other ...
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Studies on Human Thyroxine Binding Globulin: VI THE NATURE OF SLOW THYROXINE BINDING GLOBULIN
... freezing of serum. This fourth slowly migrating T 4 -binding region in electrophoretograms of cirrhotic serums is completely abolished by prior incubation with rabbit antiserum to TBG. The in vitro production of ...
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The Influence of Extracellular Thyroxine Binding Protein upon the Accumulation of Thyroxine by Tissue Slices
... Tx 3 Alternatively, despite a fixed cellular/extra+ TBCc TBCc Tx -T' cellular distribution, net thyroxine degradation wherein: might be delimited by the turnovers of TBCc or TBCEC, if: a[r] ...
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THYROXINE-BINDING GLOBULIN DEFICIENCY AND ASSOCIATED NEUROLOGICAL DEFICIT
... Laboratory tests included a normal hemogram, urinalysis, hearing tests, skull x-rays, and blood.. and urine amino acids.[r] ...
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Preparation and Properties of Thyroxine Binding Alpha Globulin (TBG)
... maximal thyroxine (T4)-binding capacity measured by reverse flow paper electrophoresis was 15,000 µg per g of protein, representing more than 2100 times that of the ...
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Thyroxine uptake by perfused rat liver No evidence for facilitation by five different thyroxine binding proteins
... (measured under conditions expected to result in dissociation-limited uptake) closely approximated the rate of spontaneous dissociation of the protein-hormone complex within the hepatic sinusoids. These findings indicate ...
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THE INTERACTION OF THYROXINE WITH PLASMA PROTEINS: LOCALIZATION OF THYROXINE BINDING PROTEIN IN COHN FRACTIONS OF PLASMA
... a Mixtures of Cohn Fractions and serum: Labelled and unlabelled thyroxine were added to sera to yield concentrations of protein bound iodine ranging from 26 to 90 ,ug.. At these PBI leve[r] ...
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THYROXINE BINDING CAPACITY OF SERUM IN NORMAL MAN
... For those experitotal serum thyroxine level of 0.25 micromole ments in which more than 15 per cent of the per liter, and the data for each section were fitted, total radioactivity was pr[r] ...
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THYROXINE BINDING BY SERUM PROTEIN IN PREGNANCY AND IN THE NEWBORN
... This finding is also con- roxine in the opposite directions In a pregnancy sistent with a low free thyroxine concentration serum with 1.4 times 10-7 M thyroxine and 5.1 and a relatively [r] ...
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CAPACITY OF THYROXINE-BINDING GLOBULIN TO BIND TRIIODOTHYRONINE AND THYROXINE IN MATERNAL AND CORD BLOOD
... The binding capacity of plasma is ac tually measured by determining the quan tity of added labeled hormone necessary to saturate the binding sites of the interaipha globulin (the thyroxi[r] ...
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Effects of Methyl Testosterone on Thyroid Function, Thyroxine Metabolism, and Thyroxine Binding Protein
... The combined effect of increased thyroxine degradation and decreased thyroxine secretion would lead to a fall in serum thyroxine and, ultimately, a new steady state in which the serum PB[r] ...
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Relative Rates of Transcapillary Movement of Free Thyroxine, Protein Bound Thyroxine, Thyroxine Binding Proteins, and Albumin
... The rate of appearance of labeled thyroxine (T4) and albumin in lymph from various areas after simultaneous i.v. injection of the labeled substances in conscious ambulatory sheep has been used to estimate the ...
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THYROXINE BINDING CAPACITY OF SERUM ALPHA GLOBULIN IN HYPOTHYROID, EUTHYROID, AND HYPERTHYROID SUBJECTS
... This thyroxine- thyroxine bound by the TBG was estimated as follows: binding globulin TBG appears to exist in plasma TBG-bound thyroxine = Aea TBG X thyroxine added Total area in quantit[r] ...
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DISPLACEMENT OF THYROXINE FROM HUMAN THYROXINE BINDING GLOBULIN BY ANALOGUES OF HYDANTOIN STERIC ASPECTS OF THE THYROXINE BINDING SITE
... A separate experiment showed that the addition of 7.28 X 10-5 M DPH, the approximate concentration of residual DPH, to plasma diluted with saline for a final protein concentration like t[r] ...
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