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Thyroxine-binding globulin

PARTIAL THYROXINE-BINDING GLOBULIN DEFICIENCY IN A FAMILY

PARTIAL THYROXINE-BINDING GLOBULIN DEFICIENCY IN A FAMILY

... : X-Chromosome linked inheritance of thyroxine binding glob- ulin deficiency. : Human thyroxine-binding globulin[r] ...

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Effects of Norethandrolone on the Transport and Peripheral Metabolism of Thyroxine in Patients Lacking Thyroxine Binding Globulin: OBSERVATIONS ON THE PHYSIOLOGICAL ROLE OF THYROXINE BINDING PREALBUMIN

Effects of Norethandrolone on the Transport and Peripheral Metabolism of Thyroxine in Patients Lacking Thyroxine Binding Globulin: OBSERVATIONS ON THE PHYSIOLOGICAL ROLE OF THYROXINE BINDING PREALBUMIN

... Studies of the effect of norethandrolone on the transport and peripheral metabolism of thyroxine were carried out in four patients lacking thyroxine-binding globulin. Before norethandrolone ...

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Sequence of the variant thyroxine binding globulin of Australian aborigines  Only one of two amino acid replacements is responsible for its altered properties

Sequence of the variant thyroxine binding globulin of Australian aborigines Only one of two amino acid replacements is responsible for its altered properties

... of thyroxine-binding globulin (TBG) with reduced affinity for hormone and increased susceptibility to heat and acid denaturation has been identified in Australian Aborigines ...

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The distribution kinetics of triiodothyronine: studies of euthyroid subjects with decreased plasma thyroxine binding globulin and patients with Graves' disease

The distribution kinetics of triiodothyronine: studies of euthyroid subjects with decreased plasma thyroxine binding globulin and patients with Graves' disease

... decreased binding capacity by thyroxine-binding globulin (TBG) abnormally high V H and C H values were found, the increase in C H being proportional to the decrease in binding activity ...

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Study of Four New Kindreds with Inherited Thyroxine Binding Globulin Abnormalities POSSIBLE MUTATIONS OF A SINGLE GENE LOCUS

Study of Four New Kindreds with Inherited Thyroxine Binding Globulin Abnormalities POSSIBLE MUTATIONS OF A SINGLE GENE LOCUS

... inherited thyroxine-binding globulin (TBG) abnormalities were ...serum thyroxine (T 4 )- binding capacity of TBG in affected males, three family types were identified: TBG deficiency, ...

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Identification of thyroxine-binding globulin as a candidate plasma marker of chronic obstructive pulmonary disease

Identification of thyroxine-binding globulin as a candidate plasma marker of chronic obstructive pulmonary disease

... COPD. Thyroxine-binding globulin (THBG) was initially identified by proteomics in a discovery panel and subsequently verified by enzyme-linked immunosorbent assay in another verification panel with a ...

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Salicylate induced increases in free triiodothyronine in human serum: Evidence of inhibition of triiodothyronine binding to thyroxine binding globulin and thyroxine binding prealbumin

Salicylate induced increases in free triiodothyronine in human serum: Evidence of inhibition of triiodothyronine binding to thyroxine binding globulin and thyroxine binding prealbumin

... demonstrated binding of T 3 to TBPA. The affinity constant for T 3 -TBPA binding appears to be slightly greater than that for albumin-T 3 ...the binding of T 3 (and T 4 ) to TBPA, it can be predicted ...

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Studies on human thyroxine binding globulin (TBG)  IX  Some physical, chemical, and biological properties of radioiodinated TBG and partially desialylated TBG

Studies on human thyroxine binding globulin (TBG) IX Some physical, chemical, and biological properties of radioiodinated TBG and partially desialylated TBG

... Thyroxine-binding globulin (TBG) and partially desialylated or slow TBG (STBG) were purified from human serum by affinity ...for thyroxine (T4), and heat-inactivation ...

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Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine binding globulin

Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine binding globulin

... To investigate the role of thyroxine-binding globulin TBG and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine T4 and tri[r] ...

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Metabolism of thyroxine binding globulin in man  Abnormal rate of synthesis in inherited thyroxine binding globulin deficiency and excess

Metabolism of thyroxine binding globulin in man Abnormal rate of synthesis in inherited thyroxine binding globulin deficiency and excess

... inherited thyroxine-binding globulin (TBG) abnormalities in man may be due to mutations at a single X-chromosome-linked locus controlling TBG ...

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Studies on Human Thyroxine Binding Globulin: VI  THE NATURE OF SLOW THYROXINE BINDING GLOBULIN

Studies on Human Thyroxine Binding Globulin: VI THE NATURE OF SLOW THYROXINE BINDING GLOBULIN

... A model system utilizing a highly purified partially desialylated thyroxine-(T 4 ) binding protein (STBG) was studied. STBG was prepared by the same affinity chromatographic method we have reported for ...

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Two new inherited defects of the thyroxine binding globulin (TBG) molecule presenting as partial TBG deficiency

Two new inherited defects of the thyroxine binding globulin (TBG) molecule presenting as partial TBG deficiency

... Serum-denatured TBG (dnTBG) measured in 32 families deficient in native TBG (nTBG) was undetectable in all subjects with complete nTBG deficiency and was high in 2 of 16 families with partial nTBG deficiency. nTBG (in ...

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Clinical Effectiveness and Cost-Effectiveness of the Use of the Thyroxine/Thyroxine-Binding Globulin Ratio to Detect Congenital Hypothyroidism of Thyroidal and Central Origin in a Neonatal Screening Program

Clinical Effectiveness and Cost-Effectiveness of the Use of the Thyroxine/Thyroxine-Binding Globulin Ratio to Detect Congenital Hypothyroidism of Thyroidal and Central Origin in a Neonatal Screening Program

... Rates of detection of pa- tients with CH of thyroidal origin (CH-T) or CH of cen- tral origin (CH-C), false-positive rates, laboratory costs, and costs of initial diagnostic evaluations.[r] ...

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The kinetics of distribution between plasma and liver of 131 I labeled L thyroxine in man: observations of subjects with normal and decreased serum thyroxine binding globulin

The kinetics of distribution between plasma and liver of 131 I labeled L thyroxine in man: observations of subjects with normal and decreased serum thyroxine binding globulin

... TABLE III Because the determination of serum T4 iodine Total T4 distribution volume, extrathyroidal pool size, and degradation rate at low levels involves considerable error, the values [r] ...

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CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE BINDING GLOBULIN OF PLASMA

CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE BINDING GLOBULIN OF PLASMA

... Thyroid I131 uptake % dose Basal metabolic rate Serum cholesterol mg % Protein-bound iodine pg % Thyroxine space TDS; L Turnover rate k; %/day Clearance rate C; Llday Organic iodine pool[r] ...

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Lack of significant binding of L triiodothyronine by thyroxine binding globulin in vivo as demonstrated by acute disappearance of 131 I labeled triiodothyronine

Lack of significant binding of L triiodothyronine by thyroxine binding globulin in vivo as demonstrated by acute disappearance of 131 I labeled triiodothyronine

... The T3 acute the T4 binding capacity of TBG in all patients half-time, on the other hand, had a mean of 76.1 studied, with a mean of 50.4 ,ug per 100 ml of minutes, which was not signifi[r] ...

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Short Stature and Thyroxine-Binding Globulin Excess: Improvement With Triiodothyronine Treatment

Short Stature and Thyroxine-Binding Globulin Excess: Improvement With Triiodothyronine Treatment

... mL, a slightly low preejection period to left ventricular ejection time ratio of 0.29 (normal 0.35 ± 0.04), and.. WISC-R IQ within normal limits.[r] ...

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DISPLACEMENT OF THYROXINE FROM HUMAN THYROXINE BINDING GLOBULIN BY ANALOGUES OF HYDANTOIN  STERIC ASPECTS OF THE THYROXINE BINDING SITE

DISPLACEMENT OF THYROXINE FROM HUMAN THYROXINE BINDING GLOBULIN BY ANALOGUES OF HYDANTOIN STERIC ASPECTS OF THE THYROXINE BINDING SITE

... A separate experiment showed that the addition of 7.28 X 10-5 M DPH, the approximate concentration of residual DPH, to plasma diluted with saline for a final protein concentration like t[r] ...

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Observations on the Nature of the Underlying Disorder and the Occurrence of Associated Plasma Transport Abnormalities in a Patient with an Idiopathic Increase in the Plasma Thyroxine binding Globulin

Observations on the Nature of the Underlying Disorder and the Occurrence of Associated Plasma Transport Abnormalities in a Patient with an Idiopathic Increase in the Plasma Thyroxine binding Globulin

... When, on the other hand, the binding of T4 was decreased by norethandrolone and the proportion of free hormone increased, the hormonal concentration in the blood declined until the free [r] ...

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THYROXINE-BINDING GLOBULIN DEFICIENCY AND ASSOCIATED NEUROLOGICAL DEFICIT

THYROXINE-BINDING GLOBULIN DEFICIENCY AND ASSOCIATED NEUROLOGICAL DEFICIT

... Laboratory tests included a normal hemogram, urinalysis, hearing tests, skull x-rays, and blood.. and urine amino acids.[r] ...

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