tissue-specific insulin resistance
Tissue specific insulin resistance in mice with mutations in the insulin receptor, IRS 1, and IRS 2
... of insulin that may potentially activate IGF-1 ...of insulin and IGF-1 receptors, it will be necessary to perform glu- cose clamps at submaximal insulin ...of insulin action, as seen in triple ...
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Acute, Muscle-Type Specific Insulin Resistance Following Injury
... the insulin signaling pathway were altered in skele- tal muscle within 60 min following trauma and ...both insulin-induced IR and IRS-1 tyrosine phosphorylation were decreased rapidly in skeletal mus- cle ...
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Anthropometric and biochemical markers of insulin resistance according to adipose tissue in overweight and obese patients: a cross sectional study
... adipose tissue is proposed as a key determinant in the genesis of non- transmissible chronic ...results, specific markers of adipose tissue such as adiponectin have been postulated as ...the ...
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A mathematical model of the euglycemic hyperinsulinemic clamp
... glucose tissue uptake during the euglycemic hyperin- sulinemic clamp could be obtained in obese subjects by waiting for up to 4–6 ...of insulin resistance as a decreased effect of the hormone on ...
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Glucose toxicity and the development of diabetes in mice with muscle specific inactivation of GLUT4
... examined insulin-stimulated glucose uptake and metabolism during hyperinsuline- mic-euglycemic clamp in control and muscle GLUT4 KO mice before and after development of dia- ...betes. Insulin-stimulated ...
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Natural killer T cells in adipose tissue prevent insulin resistance
... lipid antigens in AT preeminently suits lipid-sensitive invariant T cells such as iNKT cells, as they are triggered to release immune- polarizing cytokines by lipid/CD1d complex binding (17–19). Sec- ond, CD1d-restricted ...
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Insulin resistance causes inflammation in adipose tissue
... obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose ...adipose-specific insulin resistance (mTORC2-knockout) and diet-induced ...
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Insulin resistance in diabetes: the promise of using induced pluripotent stem cell technology
... in insulin signaling, glucose uptake, glycogen accumulation and altered insulin signaling gene expression [166], indicating the genetic defects in the skeletal ...of insulin resistant patient with ...
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Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance
... Creation of the UCP 1-Cre transgenic mice. To produce a mouse in which IR was selectively inactivated in BAT, we have used the UCP-1 gene promoter, a gene that is expressed exclusively in BAT, to direct the expression of ...
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Association between Obesity and Markers of Inflammation, Oxidative Stress and Neuronal Injury in Women with Non-alcoholic Fatty Liver
... Unexciting or bland steatosis is benign whereas NASH is described as hepatocyte lesion, where inflammation is caused by the of elicitation TNFα [3]. NAFLD pathogenesis is not completely known, and the markers that ...
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Evaluation of the Effects of Salvia Hypoleuca on the Expression of Cytokines: IL-6, IL-10 and TNF-Α in High Fat Diet-Fed Mice Towards A Cur
... including insulin- dependent Diabetes mellitus, hyperlipemia, and ...with insulin resistance ...Adipose tissue is one of the main sources of inflammatory mediators and so one of the major ...
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Glucagon-like peptide-1 (GLP-1) and protective effects in cardiovascular disease: a new therapeutic approach for myocardial protection
... Experimental studies of GLP-1 in myocardial protection A plethora of experimental data has been generated concerning a role of GLP-1 in diabetes, but very limited evidence has focused on its cardiovascular effect. Both ...
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Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population
... of insulin resistance and β-cell func- tion with prediabetes or T2DM was evaluated by mul- tivariate logistic regression analysis, in which sex, age, BMI, drinking status, LDL-C and HbA1c were ...
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Severe diabetes, age dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
... receptor or IRS-2–deficient mice (10%; refs. 39, 40). Interestingly, Akt2-deficient mice described in a recent report (25) were diabetic but did not exhibit a growth deficiency. The likely explanation for the difference ...
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Altered Lipid Responses to Dietary Interventions in Obesity
... state. Insulin and glucose have been shown to stimulate adipose tissue LPL activity and to reduce LPL activity in muscle, implying a preferential postprandial partitioning of lipoprotein- derived fatty ...
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Increased abundance of the receptor type protein tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects
... candidate insulin receptor PTPases in adipose tissue was also estimated by immunoblot ...the insulin receptor, demonstrating that the increase in LAR was responsible for the enhanced PTPase activity ...
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Stearoyl-CoA Desaturase-1 Is Associated with Insulin Resistance in Morbidly Obese Subjects
... and insulin resistance, or perhaps a ...adipose tissue as a predictor of insulin re- sistance ...the insulin resistance. In the subjects with high insulin ...
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The role of adipokines in skeletal muscle inflammation and insulin sensitivity
... increased insulin resistance in LDL- receptor deficient mice fed a high fat diet, as evidenced by reduced insulin-mediated AKT phosphorylation ...serum insulin concentrations were reduced by ...
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Cardiovascular risk escalation with caloric excess: a prospective demonstration of the mechanics in healthy adults
... Results: mean (SEM). Participants increased body weight [BW; +7.4(0.1) kg]*, body mass index [BMI; +2.5(0.2) kg/m 2 ]*, BF [+2.0(0.01)%]*, WC [+8.2(1.0) cm]*, and VAT [+0.2(0.03) L]* and intrahepatic lipid [IHL + ...
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Insulin induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles
... in insulin resist- ance, using L6 myotubes expressing myc-tagged ...GLUT4. Insulin caused membrane ruffling, a dynam- ic distortion of the myotube dorsal ...respectively. Insulin resistance ...
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