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Low Frequency of 185delAG Founder Mutation of BRCA1 Gene in Iranian Breast Cancer Patients

Low Frequency of 185delAG Founder Mutation of BRCA1 Gene in Iranian Breast Cancer Patients

In this study, the 185delAG mutation in BRCA1 gene was found in 0.5% of investigated pedigrees and in 0.75% of pa- tients. Among them, the family A showed 185delAG muta- tion in two members, including the proband (III/3) and her sister (III/2). Although they both carried the same genetic alteration and had complete penetrance, but the mutation of BRCA1 gene was associated with two different organ tar- geting (i.e. breast vs. brain cancer) and neoplastic behaviors (i.e. the malignant vs . benign natures) at almost an early age of onset (proband: 45 yr, sister: 30 yr). However, there were important key elements in families A and B, which could lead to a plan to address the challenges of preventive genetics and to consider an appropriate management for the healthy relatives as following. The age of onset for breast cancer, either in the probands or in the proband’s relatives of both families A and B, was found to be within the same range (i.e. 44-46 yr) except the 3rd cousin of proband (V/1) in family B who was affected at age of 30 and deceased at age of 35. To draw the attention towards the recorded family history of breast cancer and other malignancies, even the unrelated individuals in the same pedigree, could provide a great im- pact on the future management for their offspring. In this regard, two individuals (II/1 and II/5) in the family B could be exemplified. If they carried a mutation, the complexity of genetic alterations and the outcome for the offspring in the generation IV and V could be early diagnosed and predicted.
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The evolution of post starburst galaxies from z=2 to 0 5

The evolution of post starburst galaxies from z=2 to 0 5

Daddi et al. 2005; Damjanov et al. 2009; van der Wel et al. 2014). The current generation of simulations suggest that early quiescent, elliptical systems could have formed through strongly dissipative processes such as disc instabilities and mergers, where there is a rapid gas inflow towards the centres of the galaxies (Hopkins et al. 2009b; Wuyts et al. 2010; Dekel & Burkert 2014; Ceverino et al. 2015; Zolotov et al. 2015). In these simulations, massive and effi- cient outflows are also required to expel the remainder of the gas that is not consumed by star formation. This feedback may be caused by the rapid gas accretion leading to self-regulated star formation via supernovae feedback (e.g. Muratov et al. 2015); ‘quasar-mode’ active galactic nuclei (AGN) have also been suggested to play a role in the final removal of gas from the system (e.g. Silk & Rees 1998; Di Matteo, Springel & Hernquist 2005). These postulated feedback mechanisms should act quickly, over time-scales of the order of 10 8 yr and could explain the rapid quenching of galaxies observed.
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5-0 Overall, 0-0 Big Ten

5-0 Overall, 0-0 Big Ten

Pos. No. Name Ht. Wt. Yr. Hometown Statistical Summary G 3 Jordan Bohannon 6-1 175 RS-Sr. Marion, Iowa 7.6 ppg, 3.0 rpg, 5.0 apg G 5 CJ Fredrick 6-3 195 RS-So. Cincinnati, Ohio 11.0 ppg, 1.0 rpg, 3.2 apg F 10 Joe Wieskamp 6-6 212 Jr. Muscatine, Iowa 14.2 ppg, 6.2 rpg, 1.8 apg F 30 Connor McCaffery 6-5 205 RS-Jr. Iowa City, Iowa 3.8 ppg, 4.6 rpg, 3.8 apg C 55 Luka Garza 6-11 265 Sr. Washington, D.C. 30.4 ppg, 9.2 rpg, 2.4 bpg Head Coach: Fran McCaffery (Penn, 1979); 11th Season at Iowa (199-143); 23rd Season Overall (450-320)

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Treasury Yield Curve (percent) 2-yr/10-yr Treasury Spread (bp) 10-year Corporate Spreads (bp) 5-yr Investment Grade Corporate CDS Markit (bp)

Treasury Yield Curve (percent) 2-yr/10-yr Treasury Spread (bp) 10-year Corporate Spreads (bp) 5-yr Investment Grade Corporate CDS Markit (bp)

Avg. Mat # Issues Last Week MTD QTD YTD 1-yr Last Week Mo. Ago Beg. Qtr Beg. Year Year Ago Citi Broad IG Corp. Index 10.51 5,708 -0.86% -0.86% -0.33% -0.65% 0.41% 3.50 3.35 3.42 3.08 3.07 Industrials 11.26 3,325 -0.88% -0.88% -0.32% -1.41% -0.51% 3.69 3.54 3.66 3.24 3.20 Manufacturing 10.04 1,058 -0.98% -0.98% -0.42% -1.14% -0.03% 3.54 3.40 3.42 3.04 3.04 Aero/Defense 11.84 80 -1.24% -1.24% -0.95% -0.95% 0.74% 3.52 3.36 3.33 2.95 3.02 Automobile 6.13 95 -0.89% -0.89% 0.13% 0.37% 1.34% 2.98 2.90 2.84 2.59 2.53 Building Prods 10.89 25 -0.92% -0.92% -0.35% 1.50% 2.28% 4.06 3.80 3.76 3.13 3.12 Chemicals 11.65 156 -1.02% -1.02% -0.51% -1.37% -0.15% 3.67 3.47 3.52 3.17 3.20 Conglom/Div Mfg 11.17 135 -1.14% -1.14% -0.88% -0.48% 1.00% 3.16 3.01 2.96 2.88 2.90 Electronics 8.41 125 -0.98% -0.98% -1.21% -0.84% 0.51% 3.43 3.01 3.00 2.72 2.76 Info Tech 10.44 164 -1.01% -1.01% -1.13% -0.43% 1.07% 3.26 3.03 3.00 2.69 2.79 Machinery 7.38 88 -0.60% -0.60% -0.47% 0.08% 1.20% 2.63 2.43 2.43 2.28 2.31 Metals/Mining 11.51 111 -0.98% -0.98% 1.90% -5.18% -5.38% 5.13 5.37 5.69 4.13 3.97 Paper/Forest Prod 12.32 38 -0.60% -0.60% 0.09% 0.39% 2.14% 4.33 4.29 4.10 3.78 3.83 Textiles/Apparel 18.81 7 -1.64% -1.64% -1.41% -0.36% 1.61% 3.60 3.24 3.23 3.16 3.28 Vehicle Parts 14.29 20 -0.78% -0.78% -1.41% -3.64% -1.75
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Rapid environmental responses to climate induced hydrographic changes in the Baltic Sea entrance

Rapid environmental responses to climate induced hydrographic changes in the Baltic Sea entrance

In zone FOR-B2 the BFAR was still high, on average 55 ± 6 specimens cm −2 yr −1 (Fig. 5). The Shannon index was high, with an average of 2.8 ± 0.2 (Fig. 5). The dominant species in the zone were E. clavatum (up to 25 %) and Eggerelloides medius/scabrus (up to 15 %; Fig. 5a). The other two Elphid- ium species reached their highest relative abundances over the core (up to 6 %). Nonionella sp. T1, which had not oc- curred in the record until now, appeared in this zone with a relative abundance of 1 %. Nonionoides turgida, which was present in very low abundances along the core, had a mean abundance of 1 % in the zone (Fig. 6a). Stainfor- thia fusiformis was present with up to 9 % in relative abun- dance and a BFAR higher than in zone FOR-B1 (up to 570 specimens cm −2 yr −1 ). Ammonia batava, B. marginata, N. labradorica, and R. subfusiformis were present and ranged between 2 % and 8 %. The TOC values were increasing, with on average 3.05 % (Fig. 7). The sediment was dominated by the clay fraction that was increasing (mean value of 58 %), and the sand content was around 17 % (Fig. 7).
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cis 8 Aza­bi­cyclo­[5 2 0]­nonan 9 one

cis 8 Aza­bi­cyclo­[5 2 0]­nonan 9 one

co-existence of the most favourable twist-chair conformation (82%) and the `transient' chair form (18%), with an energy maximum on the pseudo-rotation itinerary (Hendrickson, 1961, 1967b), was also observed in cis-2-hydroxycyclo- heptanecarboxylic acid (KaÂlmaÂn et al., 2002). The di-equa- torial orientation of the -lactam moiety to the cycloheptane

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Effect of Cu2+ Doping on Structural and Optical Properties of Synthetic Zn0 5CuxMg0 5 xFe2O4 (x = 0 0, 0 1, 0 2, 0 3, 0 4) Nano Ferrites

Effect of Cu2+ Doping on Structural and Optical Properties of Synthetic Zn0 5CuxMg0 5 xFe2O4 (x = 0 0, 0 1, 0 2, 0 3, 0 4) Nano Ferrites

DOI: 10.4236/anp.2018.71001 2 Advances in Nanoparticles ing the smallest apparatus and it concentrates basically on substituting the parti- cle structures or the atomic parts of the material towards realizing new struc- tures and with the economic cost which should not exceed the raw material [1] [2]. The Nanotechnology is also regarded as the basic future sciences that will gain an increasing demand in the field of industry, medicine and transferring and transport sector and also in the field of aviation, space and telecommunica- tion [3] [4]. The biological, chemical and material properties in the Nano-size, differ from the basic shapes and properties of an atom or material itself [5] [6] [7]. Ferrites are chemical compounds with the formula of AB 2 O 4 , where A and B
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Growth. Lecture for Sydney University Nutrition & Dietetics Students Katie Barwick Dietitian The Children s Hospital at Westmead

Growth. Lecture for Sydney University Nutrition & Dietetics Students Katie Barwick Dietitian The Children s Hospital at Westmead

Mode of infant feeding can influence growth New charts represent the combined growth patterns of breast- and formula-fed infants.. WHO has developed growth charts for 0-5 yr olds usin[r]

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NIGERIA GAS ISSUES OUTLINE

NIGERIA GAS ISSUES OUTLINE

¾ PROVIDES THAT LICENCEE OR LESSEE MUST SUBMIT PROVIDES THAT LICENCEE OR LESSEE MUST SUBMIT FEASIBILITY STUDY, PROGRAMME OR PROPOSAL FOR FEASIBILITY STUDY, PROGRAMME OR PROPOSAL FOR GAS UTILIZATION NOT LATER THAN 5 YEARS AFTER THE GAS UTILIZATION NOT LATER THAN 5 YEARS AFTER THE COMMENCEMENT OF PRODUCTION.

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The evolution of post starburst galaxies from z=2 to 0 5

The evolution of post starburst galaxies from z=2 to 0 5

number density of quiescent galaxies (e.g. Moustakas et al. 2013; Moutard et al. 2016) shows that processes remain in place that quench star formation, even as the gas fractions in galaxies decrease, disks become more stable and cold gas streams shut down. The relatively constant number density of star-forming galaxies, combined with the global decline in star formation rate density by a factor of ∼ 10 since z ∼ 2 (Madau & Dickinson 2014), indicates that typical star form- ing galaxies are gradually decreasing their star-formation rates over timescales of several Gyr. However, it is unclear to what extent this decrease in the average star formation rate of star-forming galaxies is related to the formation of com- pletely quiescent galaxies. In particular, the approximately coeval increase in the fraction of galaxies with elliptical-like morphologies (e.g. Bruce et al. 2012; Buitrago et al. 2013), and the strong correlation between quiescent galaxies and a predominantly spheroid morphology at all redshifts (e.g. Bell et al. 2012; Lang et al. 2014; Bruce et al. 2014; Brennan et al. 2015; Ownsworth et al. 2016), suggests that the domi- nant quenching mechanism is more than a simple depletion of gas supplies.
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Time integrated North Atlantic Oscillation as a proxy for climatic change

Time integrated North Atlantic Oscillation as a proxy for climatic change

coupling and interconnection mechanisms, which are re- quired for reproducing a macroscopic complex system, are not. This kind of methodological problems are well known and understood in many scientific disciplines dealing with complex natural system, such as in biology and medicine (see for example a nice comment by [2]). Curry and Webster [3] have recently warned about the monstrous uncertainty implicit in the current analytical climate modelling approach, which has been interpreted as due to model inadequacy, uncertainty in model para- meter values, and initial condition uncertainty. Recently, a phenomenological and unitary approach in which the length of day (LOD) is considered as the integral of the different circulations that occur within the ocean-atmos- phere system both along latitude (zonal circulation) and longitude (meridional circulation) has been set up [4-6]. Such an approach has allowed identification of a good relationship between LOD and sea surface temperature (SST) and its forecast 4 years in advance. The North At- lantic Oscillation (NAO) is the main synoptic mode of atmospheric circulation and climate variability in the North Atlantic/European sector and has a substantial in- fluence on marine-terrestrial ecosystems and regional so- cio-economic activity. To compare the forecasting reli- ability of NAO and LOD, we integrate NAO yearly val- ues into INAO yearly data according to a sequential sum- mation of values of NAO. INAO yearly data have been calculated in such a way that they are directly propor- tional to a zonal wind speed and inversely proportional to LOD. Herein we will show that the INAO yearly values can be used as a more reliable proxy for Northern hemi- sphere air/sea temperature than LOD. Moreover, the clear identification of the 65-yr cycle in INAO and the extrapolation of such a cycle in the future suggests a gra- dual decline in global warming starting from 2005.
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Bis[2 (benzimidazol 2 yl)phenolato]zinc(II)–[2 (benzimidazol 2 ­yl)phenolato][2 (benzimidazol 2 yl) 4 bromo­phenolato]zinc(II)–ethanol–water (0 67/0 33/2/0 5)

Bis[2 (benzimidazol 2 yl)phenolato]zinc(II)–[2 (benzimidazol 2 ­yl)phenolato][2 (benzimidazol 2 yl) 4 bromo­phenolato]zinc(II)–ethanol–water (0 67/0 33/2/0 5)

In recent years, zinc(II) complexes have become important owing to their potentials in luminescence (Yu et al., 2003). We have been interested in the crystal structure and photo- luminescence of organic–metal complexes with N,O-donor ligands, e.g. 2-(benzimidazol-2-yl)phenol, 5-amino-2-(benz- imidazol-2-yl)phenol, 2-(benzoxazol-2-yl)phenol and 2- (benzothiazol-2-yl)phenol, and we have reported a number of mixed-ligand co-crystalline structures of Zn II or Be II complexes with them (Tong et al., 2004; Tong, 2005a,b). 2- (Benzimidazol-2-yl)-4-bromophenol is a homologously substituted version of 5-amino-2-(benzimidazol-2-yl)phenol, but the structure of a mixed-ligand zinc(II) complex with 2- (benzimidazol-2-yl)-4-bromophenol and 2-(benzoimidazol-2- yl)phenol has not yet been reported. We report here the structure of this mixed-ligand zinc(II) complex, (I), containing ethanol and water solvent molecules.
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Regulation of hepatic gluconeogenesis and glycogenolysis by catecholamines in rainbow trout during environmental hypoxia

Regulation of hepatic gluconeogenesis and glycogenolysis by catecholamines in rainbow trout during environmental hypoxia

A Liver pyruvate kinase activity for series I at 0-2 and 5-0mmoll ' phosphoenolpyruvate PEP concentrations and the ratio of activities at 0-2/5-OPEP and B glycogen phosphorylase activity[r]

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Pattern Recognition based Lexi-Search Approach to the Variant Multi- Dimensional Assignment Problem

Pattern Recognition based Lexi-Search Approach to the Variant Multi- Dimensional Assignment Problem

Equation (2.1) measures that the cost of the assignment of jobs on machines under the two independent factors facility and concession. Constraints (2.2) and (2.3) indicate that a job can assign on only one machine and vice versa. Constraint (2.4) and (2.5) represents that a job and a machine cannot utilize the concession, facility more than the given number of times C 0 and F 0 respectively. Finally the binary variable (2.6) i.e. X (I, j,

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12" 5" 12" 12" 5" 8'-0" 2-25 SH 2-26 SH 12" TOP OF BEAM (MAIN) 9'-4" 8'-0" FINISH FLOOR 0" GARAGE FLOOR ELEV.

12" 5" 12" 12" 5" 8'-0" 2-25 SH 2-26 SH 12" TOP OF BEAM (MAIN) 9'-4" 8'-0" FINISH FLOOR 0" GARAGE FLOOR ELEV.

9) THE GARAGE SHALL BE SEPARATED FROM THE RESIDENCE & ATTIC BY NOT LESS THEN 1/2" GYPSUM BOARD APPLIED TO THE GARAGE SIDE. GARAGES BENEATH HABITABLE ROOMS SHALL BE SEPARATED WITH NOT LESS THAN 5/8" TYPE "X" GYPSUM BOARD OR EQUIVALENT. WHERE THE SEPARATIION IS A FLOOR - CEILING ASSEMBLY, THE STRUCTURE SUPPORTING THE SEPARTION SHALL ALSO BE PROTECTED BY NOT LESS THAN 1/2" GYPSOM BOARD OR EQUIVALENT

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2,3 Bis(2 meth­oxy­phen­yl)tetra­zolium 5 thiol­ate–acetone–di­chloro­methane (1/0 4/0 1)

2,3 Bis(2 meth­oxy­phen­yl)tetra­zolium 5 thiol­ate–acetone–di­chloro­methane (1/0 4/0 1)

proposed acetone solvent molecule which was subsequently treated as disordered. From this we were able to detect a minor component of dichloromethane solvate as well. The occupancy ratios for these two solvent molecules were obtained from free-refining their occupancies, and later fixing these values to 80:10 for acetone and dichloromethane, respectively. The positions of the –CH 3 and –CH 2 moieties of the two solvents could not be defined clearly and was

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Comparative Evaluation of the Efficacy of the Bimatoprost 0 03%, Brimonidine 0 2%, Brinzolamide 1%, Dorzolamide 2%, and Travoprost 0 004%/Timolol 0 5% Fixed Combinations in Patients Affected by Open Angle Glaucoma

Comparative Evaluation of the Efficacy of the Bimatoprost 0 03%, Brimonidine 0 2%, Brinzolamide 1%, Dorzolamide 2%, and Travoprost 0 004%/Timolol 0 5% Fixed Combinations in Patients Affected by Open Angle Glaucoma

[1] S. D. Vold, R. M. Evans, R. H. Stewart et al., “A One- Week Comfort Study of BID-Dosed Brinzolamide 1%/ Timolol 0.5% Ophthalmic Suspension Fixed Combina- tion Compared to BID-Dosed Dorzolamide 2%/Timolol 0.5% Ophthalmic Solution in Patients with Open-Angle Glaucoma or Ocular Hypertension,” Journal of Ocular Pharmacology and Therapeutics, Vol. 24, No. 6, 2008, pp. 601-605. doi:10.1089/jop.2008.0030

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Prevalence of undiagnised thyroid dysfunction in diagnosed cases of gallbladder stones

Prevalence of undiagnised thyroid dysfunction in diagnosed cases of gallbladder stones

thyroid hormones are having a number of effects on cholesterol metabolism [5]. In hypothyroidism serum cholesterol values rises which in turn leads to super saturation of bile with cholesterol, leading to gallbladder hypo motility, decreased contractibility and impaired filling, giving rise to [6-8] prolonged residence and flow capacity of bile in the gallbladder. These events may contribute to the retention of cholesterol crystals, thereby allowing sufficient time for nucleation and continual growth into mature [6] gall stones. In

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cohesion the marker of success (Erie, 2004; Keil and Young, 2008). The spatial consequences of such a fundamental social reorientation are visible in the just-in-time landscapes of transportation and information infrastructures that have laced metropolitan regions since the 1980s. This is the Walmartized, strip-mall landscape of automobile convenience, which values temporal availability (for producers and consumers) over quality and space (for warehousing, transportation, and mass distribution on one hand and single family monster homes in the far reaches of the commuter shed on the other) over other considerations (e.g., density, proximity, and sustainability). The aforementioned study on “megacity challenges” concludes that while “transport overtakes all other infrastructures concerns … the environment matters but may be sacrificed for growth” (GlobeScan, 2007, 7). In this context, we also need to mention that urban regions are but part of larger urbanization clusters such as the regional megalopolis of the Atlantic seaboard in the United States. A recent study of the area concludes, “Overall, the forces of urban decentralization have changed Megalopolis from a region of big city population to a more fully suburbanized agglomeration” (Vicino, Hanlon, and Short, 2007, 348). In the Quebec-Windsor corridor in Canada, as well as in the Edmonton-Calgary corridor and the lower mainland of British Columbia, we see similar tendencies towards large-scale suburbanized agglomeration. The governments of Ontario, Quebec, and Canada have addressed the specific transportation and infrastructure issues of the Quebec City– Windsor corridor with a planned Ontario-Quebec Continental Gateway and Trade Corridor. As is the case with the transportation networks in the regional Places to Grow planning efforts, these transregional plans cut more transversals through the in-between city, treating these areas as terrain to be overcome rather than as places to stay, inhabit, or produce. 2 Perhaps the most visible outgrowth of this tendency is the globally financed,
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