toll-like receptor 3
Toll Like Receptor 3/TRIF Dependent IL 12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells
... ABSTRACT A functional immune response is crucial to prevent and limit infections with Streptococcus pneumoniae. Dendritic cells (DCs) play a central role in orchestrating the adaptive and innate immune responses by ...
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Baculovirus Transduction of Mesenchymal Stem Cells Triggers the Toll-Like Receptor 3 Pathway
... Surprisingly, Toll-like receptor-3 (TLR3), a receptor that generally recog- nizes double-stranded RNA, was apparently upregulated by BV transduction, as confirmed by microarray, PCR ...
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Friend retrovirus drives cytotoxic effectors through Toll like receptor 3
... Background: Pathogen recognition drives host defense towards viral infections. Specific groups rather than single members of the protein family of pattern recognition receptors (PRRs) such as membrane spanning ...
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Toll-like receptor 3 is a therapeutic target for pulmonary hypertension
... deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and TLR3 double IF, lung tissue sections were stained using the ApopTag Fluorescein In Situ Apoptosis Detection Kit (Millipore Sigma, Burlington, MA) and TLR3 ...
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Toll like receptor 3 activation selectively reverses HIV latency in microglial cells
... eter plate and incubated overnight. Cells were then left untreated or treated with either TNF-α (10 ng/mL), poly (I:C) (100 ng/mL) or LPS (10 ng/mL) for 30 min. The cells were then cross-linked in 1% formaldehyde, ...
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Toll Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection
... Because TLR3 senses double-stranded RNAs, an intermediate nucleic acid species present during acute viral infections, it could be predicted that loss of TLR3 signaling would negatively impact the host and alter cellular ...
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HIV-1 Lentiviral Vector Immunogenicity Is Mediated by Toll-Like Receptor 3 (TLR3) and TLR7
... Lentiviral vector production, titration, and transduction of DC. (i) Plasmids. The transfer vectors pHR⬘trip CMV GFP SIN (7), pHR⬘trip CMV luc2-Ires- tNGFR SIN (28), pHRSIN-CSGW, and pHRSIN-Thy1.1 (3) were ...
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Toll-like receptor 3 modulates the behavioral effects of cocaine in mice
... as endogenous ligands for TLR3 through their secondary structures [45]. Moreover, cancer therapeutic RNA com- pounds induce cell death in tumors and serve as TLR3 ligands [46]. Therefore, identification of specific ...
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Immunoprivileged status of the liver is controlled by Toll like receptor 3 signaling
... The liver represents a so-called immunoprivileged site according to its relative resistance against organ rejection after transplanta- tion (1). This is in contrast to the rapid rejection of purified trans- planted ...
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Molecular cloning of Peking duck Toll like receptor 3 (duTLR3) gene and its responses to reovirus infection
... Fig. 3 DRV (TH11) infection induces the expression of TLR3, IFN- α , NF κ B, Mx, OASL, ISG12 and IFITM1 in CCL-141 cells. a Gene responses in duck embryo fibroblast cells incubated with DRV (TH11) at a ...
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Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts
... Interestingly, activation of HCE TLR3 and TLR4 by poly I:C and LPS, while stimulating secretion of pro- inflammatory cytokines and the up-regulation of their respective genes, was found to decrease TLRs surface ex- ...
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Cancer testis antigen and immunotherapy
... cell receptor; TLR3, toll-like receptor 3; MAGE-A1, melanoma antigen family A, 1; MAGE-A3, melanoma antigen family A, 3; NY-ESO-1, New York esophageal squamous cell carcinoma; ...
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It takes two: potential therapies and insights involving microglia and macrophages in glioblastoma
... inhibition. toll- like receptor 3 (TLR3), CX3CR1, and TLR9 are both present on both microglia and macrophages; (C) pro-tumor or tumor-progressive pathways in microglia that are associated with ...
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Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
... TLR1 Toll-like receptor 1 TLR2 Toll-like receptor 2 TLR3 Toll-like receptor 3 TLR4 Toll-like receptor 4 TLR5 ...
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Toll like receptor downstream signaling
... A third TIR-domain containing the adapter TRIF (also known as TICAM1) was independently identified by the database search and as an interacting partner with TLR3 by yeast two-hybrid screening (Fig. 2) [40,41]. Initial ...
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Toll-like receptor cascade and gene polymorphism in host–pathogen interaction in Lyme disease
... A number of genotype–phenotype matching studies were carried out to elucidate the functional effects of gene poly- morphisms in TLRs on host cytokine synthesis in response to B. burgdorferi infection (Table 3). ...
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Toll and Toll like receptor signalling in development
... via Toll-3 and Toll-9 to trigger, via Dorsal and Dif, the Reaper-induced apoptosis of loser mutant cells, or via Toll-2, -4, -8 and -9 to induce the apoptosis of loser wild-type cells via ...
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Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling
... Hepes, 10 mM; glucose, 10 mM; adjusted to pH 7.4 and osmolarity 300 mosM. The recordings were obtained at room temperature. Electrodes were filled with 1.0 M KCl (impedance: 40 to 80 MΩ) and posi- tioned by a ...
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RIG-I-Like Receptor and Toll-Like Receptor Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in a Severe Fever with Thrombocytopenia Syndrome Virus Infection Mouse Model
... mice in the presence of granulocyte macrophage colony-stimulating factor (GM-CSF) or Fms-like tyrosine kinase 3 ligand (Flt3L). GM-CSF generates cDCs, and Flt3L generates a mixture of cDCs and pDCs. These ...
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Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess
... immunoglobulin receptor genes, Fc𝜸RIIa and Fc𝜸RIIIb. [3] There have been suggestions indicating a role for genetic variations in genes encod- ing pro inflammatory cytokines, [6, 9-11] and pattern ...
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