Toll-like receptor 9
Toll like receptor 9–induced type I IFN protects mice from experimental colitis
... of Toll-like receptor 9 (TLR9) (5). Like other TLR ligands such as LPS, ISS-ODN has a broad range of effects on the mammalian innate immune ...
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Amyloid β and Tau Alzheimer’s disease related pathology is reduced by Toll-like receptor 9 stimulation
... via Toll-like receptor 9 (TLR9) agonists, such as type B CpG oligodeoxynucleotides (ODNs), might be an effective way to ameliorate AD related ...
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CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo
... via Toll-like receptor 9 (TLR9) potentially leading to septic shock [20,21], septic arthritis [22], or meningitis ...same receptor system (TLR9) ...
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Human lung cancer cells express functionally active Toll-like receptor 9
... Background: CpG-oligonucleotides (CpG-ODN), which induce signaling through Toll-like receptor 9 (TLR9), are currently under investigation as adjuvants in therapy against infections and cancer. ...
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Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer
... of Toll-like receptor-9 (TLR9) in prostate cancer is not totally ...genes, like matrix metallopeptidase 2 (MMP2), matrix metallopeptidase 9 (MMP9), chemokine receptor 4 ...
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Original Article Toll-like receptor 9 inactivation ameliorates ox-LDL injured HUVEC activity in vitro
... patients. Toll-like receptor 9 (TLR9) is an innate inflammatory receptor, and is enhanced in human umbilical vein endothelial cells (HUVECs) under high glucose ...
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Involvement of the Toll-Like Receptor 9 Signaling Pathway in the Induction of Innate Immunity by Baculovirus
... We have previously shown that mice inoculated intranasally with a wild-type baculovirus (Autographa californica nuclear polyhedrosis virus [AcNPV]) are protected from a lethal challenge by influenza virus. However, the ...
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The T Antigen Locus of Merkel Cell Polyomavirus Downregulates Human Toll-Like Receptor 9 Expression
... Establishment of a chronic infection is a key event in virus-mediated carcinogenesis. Several cancer-associated, double-stranded DNA (dsDNA) viruses act via their oncoproteins to downregulate Toll-like ...
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Downregulation of Toll-Like Receptor 9 Expression by Beta Human Papillomavirus 38 and Implications for Cell Cycle Control
... Innate immunity is the first line of host defense against infections. Many oncogenic viruses can deregulate several immune-re- lated pathways to guarantee the persistence of the infection. Here, we show that the ...
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Single Nucleotide Polymorphisms of Toll Like Receptor 7 and Toll Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
... of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han ...
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Heterogeneity of Toll like receptor 9 signaling in B cell malignancies and its potential therapeutic application
... Toll-like receptor 9 (TLR9) is expressed in a variety of B-cell malignancies and works as a bridge between innate and adaptive immunity. CpG oligodeoxynucleotides (CpG ODNs), TLR9 agonists, ...
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Toll-Like Receptor 9-Mediated Inflammation Triggers Alveolar Bone Loss in Experimental Murine Periodontitis
... (13). Toll like receptor 9 (TLR9) is the major sensor for microbial unmethylated/hypom- ethylated CpG (cytosine-phosphate-guanosine) DNA ...
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Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma
... Toll-like receptors (TLRs) are pattern recognition receptors that detect both microbe- and host-derived molecular patterns. Thus far, at least 13 mammalian TLRs have been recognized, each of them responding ...
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Potential association of pulmonary tuberculosis with genetic polymorphisms of toll like receptor 9 and interferon gamma in a Chinese population
... IFN-γ is one of the most widely studied candidate gene potentially associated with TB susceptibility. Positive associ- ations with PTB susceptibility have been observed for mul- tiple SNPs as assessed by individual ...
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Toll-like receptor 9 partially regulates lung inflammation induced following exposure to chicken barn air
... macrophages without any effect on neutrophils or total cells in the BAL in TLR9 − / − mice is interesting when combined with fewer tissue neutrophils but comparable tissue macrophages af[r] ...
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Toll like receptor 9 polymorphisms influence mother to child transmission of human immunodeficiency virus type 1
... transduction pathways, that in turn induce dendritic cell maturation and cytokine production [2]. These receptors play a central role in the activation of innate immunity [3]. A growing body of data supports a role of ...
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Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis
... [8]. Toll-like receptors (TLRs) are a group of trans-membrane receptors activated by conserved molecular patterns of microbes ...the receptor for unmethylated CpG dinucleotides, found in bacterial ...
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Toll-Like Receptor 9 and Interferon-Gamma Receptor Signaling Suppress the B Cell Fate of Uncommitted Progenitors in Mice
... phosphatase receptor type C (B220), and ...cell receptor leads to apoptosis while stimulation of the more mature Transitional 3 cells leads to proliferation and further maturation, suggesting that ...
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Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer’s disease in Han Chinese
... Toll-like receptors (TLRs) are a family of innate immune mediators that are expressed by a variety of immune and nonimmune cells [5]. There are at least 13 distinct TLR family members known in mammals, of ...
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Toll-like receptor 9 interaction with CpG ODN – An in silico analysis approach
... TLR9 is a receptor for sensing bacterial DNA/CpG-containing oligodeoxynucleotides (CpG ODN) within the endosomal compartment [4]. Internalised CpG DNA within the endosome initiates TLR9-mediated signalling via the ...
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