topoisomerase I
Simian Virus 40 DNA Replication Is Dependent on an Interaction between Topoisomerase I and the C-Terminal End of T Antigen
... Topoisomerase I (topo I) is needed for efficient initiation of simian virus 40 (SV40) DNA replication and for the formation of completed DNA ...topo I have been previously mapped to the ...
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Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition
... In this study, we have shown that the AT/RT cell lines produce a number of cytokines and the multi-kinase inhi- bitors sorafenib and sunitinib induce cell growth inhibition in these cell lines. The effect of sorafenib ...
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MOLECULAR DOCKING STUDIES OF INDENOISOQUINOLINE DERIVATIVES WITH DNA TOPOISOMERASE I COMPLEX
... cancer. Topoisomerase I (Top 1) an essential enzyme that participates in the processes associated with separation of DNA strands and manages the super helical tensions through the transient breakage of one ...
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A role for topoisomerase I in Fusarium graminearum and F. culmorum pathogenesis and sporulation
... The capacity to sporulate asexually was reduced in the F. graminearum top1 mutants and was abolished in the F. cul- morum top1 mutants. The wild-type strain of F. graminearum readily developed perithecia (sexual spore ...
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Multiple Endonucleases Function to Repair Covalent Topoisomerase I Complexes in Saccharomyces cerevisiae
... Topoisomerase I plays a vital role in relieving tension on DNA strands generated during ...damage, topoisomerase protein complexes may stall replication forks producing DNA double-strand breaks ...
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Localization of a high molecular weight form of DNA topoisomerase I in amphibian oocytes
... Int J De' BioI 40 239 244 (1996) 239 I I I I I I I I I I I I I I I I I I I I I I Localization of a high molecular weight form of DNA topoisomerase I in amphibian oocytes DAGMAR GEBAUER', CHRISTINE MAI[.] ...
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Topoisomerase I Is Essential in Cryptococcus neoformans: Role in Pathobiology and as an Antifungal Target
... A, ApaI; X, XbaI; S, SalI; RV, EcoRV; P, PstI. However, the GAL7::TOP1 strain was viable on glucose medium, revealing that even under repressing condi- tions, enough topoisomerase I is expressed to support ...
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The HLA DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma)
... anti-topoisomerase I antibodies (anti-topo ...topo I positive patients, compared with 44% of anti-topo I negative patients (P < ...anti-topo I positive sera to four different ...
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T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors
... DNA topoisomerase I (topo I) was examined in 26 systemic sclerosis (SSc) patients with anti-topo I antibody, 10 SSc patients without anti- topo I antibody, and 21 healthy ...topo ...
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ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.
... DNA Topoisomerase I (Top1) forms a transient and ‘‘reversible’’ intermediate where it becomes covalently attached to the 39-terminus of a DNA nick, called Top1-cleavage complex ...
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Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts
... The Topoisomerase I Assay kit (TopoGEN ...topo I at serial ...topo I was determined by measuring the intensity of the super- coiled DNA bands after reactions with a serial dilution of topo ...
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Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target
... of topoisomerase I (Topo I). Topo I is an attractive actionable molecular cancer target because there are experimental and clinically used Topo I ...Topo I expression in breast ...
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The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis
... DNA topoisomerase I (Topo I) is a 765-amino-acid nuclear enzyme [9] involved in topological changes of DNA structure ...Topo I cat- alytic process, a transient covalent linkage, termed the ...
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Diagnostic value of anti topoisomerase I antibodies in a large monocentric cohort
... Anti-topo I antibodies were detected by commercially available, CE-certified monospecific LIA (Anti- Scl-70 EUROLine) and ELISA (Anti-Scl-70 ELISA) provided by EUROIMMUN AG (Lübeck, ...DNA topoisomerase ...
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In silico identification of novel Topoisomerase I inhibitors: Application of ligand based pharmacophore modeling and chemical database mining
... year’s topoisomerase I inhibitors like indenoisoquinolines have become important new lead for rational design of anticancer drugs due to their greater physiological and DNA-enzyme cleavage complexes ...good ...
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Dihydrobetulinic Acid Induces Apoptosis in Leishmania donovani by Targeting DNA Topoisomerase I and II: Implications in Antileishmanial Therapy
... DNA topoisomerase I and II activity was studied using relaxation and decatena- tion ...DNA topoisomerase I and II, has no effect on parasitic growth, and also fails to induce ...
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Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
... China. Topoisomerase I and II drug screening kits were bought from Topogen ...erase I (TOP I) and TOP II were bought from Cloud- clone ...
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Topoisomerase I and RecQL1 Function in Epstein-Barr Virus Lytic Reactivation
... the topoisomerase I (Topo I) inhibitor camp- tothecin and the Topo II inhibitor ellipticine can inhibit EBV replication at concentrations that were not toxic to the host cell ...Topo I has ...
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CKD-602, a topoisomerase I inhibitor, induces apoptosis and cell-cycle arrest and inhibits invasion in cervical cancer
... Topoisomerase I (TOP1) inhibitors (e.g. toptecan and iritonecan) are currently used in the treatment of cer- vical cancer treatment (https://www.nccn.org). Previous studies have demonstrated that CKD-602, a ...
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Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan
... topo I might be a targeted therapy for ...topo I inhibition is the underlying mechanism ...topo I alone increased binding of anti-dsDNA antibodies [21, 22] supposing that DNA relaxation is critically ...
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