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toxin expression

Characterization of Alpha Toxin hla Gene Variants, Alpha Toxin Expression Levels, and Levels of Antibody to Alpha Toxin in Hemodialysis and Postsurgical Patients with Staphylococcus aureus Bacteremia

Characterization of Alpha Toxin hla Gene Variants, Alpha Toxin Expression Levels, and Levels of Antibody to Alpha Toxin in Hemodialysis and Postsurgical Patients with Staphylococcus aureus Bacteremia

... alpha-toxin expression is highly con- ...alpha-toxin expression levels were approximately 2-fold higher in ...vitro expression may not cor- relate with in vivo ...alpha- toxin ...

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TECS: a toxin expression control strategy as a tool for optimization of inducible promoters

TECS: a toxin expression control strategy as a tool for optimization of inducible promoters

... Results: In order to facilitate optimization process for inducible promoters, we developed a simple method based on a conditional toxin expression which we abbreviate as toxin expression ...

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The Emergence of Successful Streptococcus pyogenes Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression

The Emergence of Successful Streptococcus pyogenes Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression

... period; as expected, this again identified the shift in the emm89 population. Other emm types exhibited lineages with different P-nga-ifs-slo variants, and those with the more active promoter variant did appear to become ...

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Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization

Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization

... elevated toxin production, as its activated form binds to both P2 and P3 promoters to drive the agr regulon and decrease repressor of toxin (rot), ...

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Toxigenic and non-toxigenic patterns I, II and III and biofilm-forming ability in Bacteroides fragilis strains isolated from patients diagnosed with colorectal cancer

Toxigenic and non-toxigenic patterns I, II and III and biofilm-forming ability in Bacteroides fragilis strains isolated from patients diagnosed with colorectal cancer

... that toxin may not be a crucial factor for the formation of this phenotype ...of toxin regulating two- component system RprXY on bft-gene expression in vivo and in vitro ...the expression of ...

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The role of flagella in Clostridium difficile pathogenesis:
comparison between a non epidemic and an epidemic
strain

The role of flagella in Clostridium difficile pathogenesis: comparison between a non epidemic and an epidemic strain

... the expression of ...of toxin production is as yet ...of toxin expression level in the flgE-mutant, which suggests a regulatory mechanism between flagella and toxin expression at ...

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Characterisation of the Binding Properties of Bacillus Thuringiensis 18 Toxin on Leukaemic Cells

Characterisation of the Binding Properties of Bacillus Thuringiensis 18 Toxin on Leukaemic Cells

... 18 toxin, from Bt 18, a Malaysian isolate, was selectively cytotoxic against CEM-SS but not human T lymphocytes and was non-haemolytic ...the toxin binds to a specific receptor on CEM-SS and that it ...

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Pertussis Toxin potentiates Th1 and Th2 responses to co injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co stimulatory molecules B7 1, B7 2 and CD28

Pertussis Toxin potentiates Th1 and Th2 responses to co injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co stimulatory molecules B7 1, B7 2 and CD28

... As well being a major virulence factor, PT is considered to be a key component of the protective immune response to B. pertussis (2,15). PT-specific T cell and antibody responses are generated following recovery from B. ...

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Understanding gene expression with a pore forming toxin

Understanding gene expression with a pore forming toxin

... Figure 1.12 Genome-wide gene expression analysis reveals a huge reshaping of the translational level of gene expression. (a) Diagram outlining the experimental design followed for transcriptome and ...

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Characterization of a Xanthomonas campestris pv. zinniae Oxidoreductase Involved in the Biodegradation of Cercosporin

Characterization of a Xanthomonas campestris pv. zinniae Oxidoreductase Involved in the Biodegradation of Cercosporin

... Complementation of the cercosporin-sensitive mutants identified three genes that are involved in cercosporin resistance. Complementation of the CS10 mutant led to identification of the gene CRG1, which encodes a zinc ...

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A Poly N Acetylglucosamine−Shiga Toxin Broad Spectrum Conjugate Vaccine for Shiga Toxin Producing Escherichia coli

A Poly N Acetylglucosamine−Shiga Toxin Broad Spectrum Conjugate Vaccine for Shiga Toxin Producing Escherichia coli

... Shiga toxin (Stx)-producing Escherichia coli (STEC), an important group of gastrointestinal (GI) pathogens for which effective immuno- therapeutics are ...Shiga toxin 1b subunit (9GlcNH 2 -Stx1b) ...

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Expression Cloning of cDNAs That Render Cancer Cells Resistant to Pseudomonas and Diphtheria Toxin and Immunotoxins

Expression Cloning of cDNAs That Render Cancer Cells Resistant to Pseudomonas and Diphtheria Toxin and Immunotoxins

... Initially, 30 pools of MCF-7/T cells (5 x 106 cells each pool) were electroporated with each 15 ,g of pCDM8-HeLa cDNA library plasmids as de- scribed above and incubated for 15 hr withou[r] ...

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Expression of apoptosis-regulating genes in the rat prostate following botulinum toxin type a injection

Expression of apoptosis-regulating genes in the rat prostate following botulinum toxin type a injection

... Background: Onabotulinumtoxin A (OnabotA) injection has been investigated as a novel treatment for benign prostatic enlargement caused by benign prostatic hyperplasia. An OnabotA - induced volume reduction caused by ...

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Design, expression, and testing of a bivalent subunit botulism vaccine for use in cattle

Design, expression, and testing of a bivalent subunit botulism vaccine for use in cattle

... Botulism intoxication in cattle is a serious problem that needs to be addressed. Current vaccines offer protection but are based on lysed cells and inactivated toxin. These formulations are dangerous to produce ...

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Increase in the expression of a family of small guanosine triphosphate binding proteins, rab proteins, during induced phagocyte differentiation

Increase in the expression of a family of small guanosine triphosphate binding proteins, rab proteins, during induced phagocyte differentiation

... phagocytes display functions requiring organized intracellular traffic and, for this reason, we questioned whether phagocyte differentiation could correlate with the increased expression of rab proteins. Rabbit ...

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Production of fluorescent and cytotoxic K28 killer toxin variants through high cell density fermentation of recombinant Pichia pastoris

Production of fluorescent and cytotoxic K28 killer toxin variants through high cell density fermentation of recombinant Pichia pastoris

... era toxin B-subunit was successfully labelled with Cy3 and used for in vivo tracking of its retrograde trans- port in Vero cells [23], this technique is inappropriate for the viral toxin K28 since the low ...

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The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig

The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig

... reactive base able to react to low doses of nitric oxide forming a fluorescent compound which is detectable by flow cytometry. DAF-FM was used at 10 μM according to the manufacturer’s protocol (Invitrogen). After DAF- FM ...

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Evaluation of Enzyme Immunoassays and Real Time PCR for Detecting Shiga Toxin Producing Escherichia coli in Southern Alberta, Canada

Evaluation of Enzyme Immunoassays and Real Time PCR for Detecting Shiga Toxin Producing Escherichia coli in Southern Alberta, Canada

... N on-O157 Shiga toxin-producing Escherichia coli (STEC) is an emerging cause of enteric and systemic illness and account for 50% of STEC infections (1, 2). Serotypes O104, O121, O26, O145 and O157 (1–6) have been ...

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Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages

Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages

... the expression of neprilysin, an Aβ degradation enzyme ...in toxin (MPTP+ 3-NP)-induced (1 × 10 6 cells/tail vein) or transgenic MSA (5 × 10 5 cells/tail vein) animal models [67, ...

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A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells

A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells

... cell–specific expression of a ...the expression of an attenuated diphtheria toxin (DT) gene driven by the ITF promoter; other cell lineages were unaf- ...

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