transcription-dependent nuclear localization
Roscovitine Inhibits EBNA1 Serine 393 Phosphorylation, Nuclear Localization, Transcription, and Episome Maintenance
... The high-resolution crystal structure of the EBNA1 DDBD (aa 459 to 607) bound to DNA (6), the essential role of this domain in all cognate oriP specific interactions, and the op- portunity to use the structure to ...
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Degradation of Saccharomyces cerevisiae Transcription Factor Gcn4 Requires a C-Terminal Nuclear Localization Signal in the Cyclin Pcl5
... basal transcription of the Gcn4 target genes HIS4 and ARO4 or the level of induction after 3-AT (3-amino-1,2,4- triazole) treatment compared to a PCL5 wild-type strain or a pcl5 mutant strain expressing PCL5-GFP ...
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Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral RNA synthesis and transcription and inhibiting host cell transcription
... Aryl hydrocarbon receptor is a ligand-activated tran- scription factor, whose activation induces the expression of numerous genes and modulates host responses against viral infection [36, 37]. It is reported that AHR ...
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Multiple Nuclear Localization Signals Mediate Nuclear Localization of the GATA Transcription Factor AreA
... GATA transcription factors regulate transcription of genes in- volved in a range of processes, including hematopoiesis and car- diac development in mammals, as well as nitrogen metabolism, iron siderophore ...
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The role of nuclear localization signal in parvovirus life cycle
... the nuclear pore complex freely or by passive diffusion, while the larger proteins (>50 kDa) require active trans- ...the nuclear pore complex ...
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The role of WNT /β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines
... Firstly, we evaluated the level of expression of β-catenin in a panel of freshly isolated melanoma cells by western blot analysis. Quantitative analysis of β-catenin protein as well as its functional activation, measured ...
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Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression.
... of nuclear localization mutants of ICP27 on the localization of other viral proteins involved in late gene ex- pression and DNA ...the localization of both of these immedi- ate-early proteins ...
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MS-based approaches enable the structural
... Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. Regulation of FoxO transcription factors by acetylation and[r] ...
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A Highly Organized Structure Mediating Nuclear Localization of a Myb2 Transcription Factor in the Protozoan Parasite Trichomonas vaginalis
... subcellular localization and distribution of overexpressed Myb2 ...E), nuclear translocation of Myb2 was substantially perturbed with an ap- parent accumulation of Myb2 near the nuclear membrane in a ...
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The Open Reading Frame 57 Gene Product of Herpesvirus Saimiri Shuttles between the Nucleus and Cytoplasm and Is Involved in Viral RNA Nuclear Export
... ORF 57 increases cytoplasmic transport of viral mRNA. It has been previously shown that ORF 57 transactivates a range of HVS promoters, including glycoprotein B (gB) and capsid, but does not significantly alter the level ...
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Graphene quantum dots in alveolar macrophage: uptake-exocytosis, accumulation in nuclei, nuclear responses and DNA cleavage
... regulate nuclear uptake of AG-QDs. AG-QDs in nu- cleus altered nuclear morphology, decreased nuclear areas, and reduced nuclear ...potential nuclear toxicity and DNA damage mediated by ...
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Phosphorylation meets nuclear import: a review
... of nuclear import that has important physiological consequences in humans is the parathyroid hormone related protein ...The nuclear import of PTHrP is down regulated by the cell cycle-dependent ...
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Classic Nuclear Localization Signals and a Novel Nuclear Localization Motif Are Required for Nuclear Transport of Porcine Parvovirus Capsid Proteins
... the nuclear pore com- plex ...Classic nuclear transport mechanisms proceed after recognition of a nuclear lo- calization signal (NLS) by the transport machinery (usually im- portin- ␣ or importin-  ...
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Localization and abundance analysis of human lncRNAs at single cell and single molecule resolution
... We applied this analysis to every probe set in each of the three cell types (HeLa, hLF, hFF) in which it displayed a signal. A probe set was considered invalid in a specific cell type if there was either (Figure 1a, ...
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Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis.
... Deoxyribose-1-phosphate (dRP) has previously been de- scribed as an endogenous molecule capable of stimulating angiogenesis in an ROS-dependent manner both in vitro and in vivo (7, 24, 42, 49, 50, 58). The ...
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Ederle, Helena (2018): Identification of the nuclear export pathways of TDP‐43 and FUS. Dissertation, LMU München: Graduate School of Systemic Neurosciences (GSN)
... in nuclear export and neuronal diseases came from work on nucleoporin GLE1, a key component of the mRNA export ...deplete nuclear pore complexes of the GLE1 protein in HeLa ...
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Simplet/Fam53b is required for Wnt signal transduction by regulating β catenin nuclear localization
... 3. Nuclear localization of β -catenin requires the Smp nuclear localization ...the nuclear localization signal ...the nuclear localization signal (white ...the ...
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Replication but Not Transcription of Simian Virus 40 DNA Is Dependent on Nuclear Domain 10
... their transcription and replication adjacent to a specific nuclear domain, ...ND10-associated transcription only when the origin and the coding sequence for the large T antigen were ...localize ...
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Emerin Is Hyperphosphorylated and Redistributed in Herpes Simplex Virus Type 1-Infected Cells in a Manner Dependent on both UL34 and US3
... the nuclear membrane that might be respon- sible for emerin ...the nuclear membrane ...viruses. Nuclear-lamina fractions were prepared, separated on SDS-PAGE gels, and probed for emerin ...
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Epstein-Barr Virus Nuclear Protein 3A Domains Essential for Growth of Lymphoblasts: Transcriptional Regulation through RBP-Jκ/CBF1 Is Critical
... EBNA3A aa 170 to 240, 300 to 386, and 386 to 523 are critical for LCL growth. To identify EBNA3A domains critical for maintaining LCL growth, a series of FLAG-tagged EBNA3A mutants was cloned into an oriP-based vector ...
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