transcription enhancer factor-1
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements
... of transcription factors in these TSS distal clusters could be to modulate the chromatin environment around genes, to work as enhancer elements directed towards their own gene or distant genes, or to ...
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Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia
... IgG 1:100) (Santa Cruz Biotechnology, Cat. No. sc-28879); Notch-1 (rabbit polyclonal IgG 1:100) (Santa Cruz Biotechnology, ...IgG 1:200) (Merck KGaA, ...IgG 1:100) (Santa Cruz ...
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Involvement of TORC2, a CREB co activator, in the in vivo specific transcriptional control of HTLV 1
... HTLV-1 transcription in vivo and found that expression of TORC1 and TORC2 in EL4-Gax cells coincided with the suppressed expression of Gax in vivo and its up-regulation in vitro or ex ...the ...
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The E47 transcription factor binds to the enhancer sequences of recombinant murine leukemia viruses and influences enhancer function.
... of enhancer activity of the two enhancers were repeated in normal cells and cells that over- expressed the E47 ...synthetic enhancer with six tandem E47- binding sites which was specifically designed to ...
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Role of the Proximal Enhancer of the Major Immediate-Early Promoter in Human Cytomegalovirus Replication
... Sp-1 transcription factor to the two putative Sp-1 binding ...(Fig. 1). The consensus Sp-1 binding sites are ...Lanes: 1, putative Sp1 probe around position ⫺ 60 plus ...
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Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores.
... binding factor (CBF), also known as polyomavirus enhancer-binding protein 2 and SL3 enhancer factor 1, is a mammalian transcription factor that binds to an element termed ...
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Functional CRISPR screen identifies AP1 associated enhancer regulating FOXF1 to modulate oncogene induced senescence
... an enhancer-binding transcription factor (TF), whose function in transcriptional regulation is re- quired for its tumor suppressive activity, we previously performed a CRISPR-based functional genomic ...
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Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila
... the enhancer, suggesting that their position relative to each other is ...specific transcription factor] to predict TFBSs within S2E orthologs reveals that an extensive genomic reorganization of ...
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Transcription factors: Are they a real target for future therapeutic strategies?
... Furthermore, transcription factors can only exert their function if they find a specific the DNA sequence and folding pattern that has to be associated with the right chromatin ...essential transcription ...
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An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
... forebrain transcription factor to I56i is affected by the ...I56i enhancer as shown by DNaseI footprinting ...I56i enhancer (nucleotides 1-276) was incubated with a nuclear protein ...
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CCAAT/enhancer binding protein β promotes receptor activator of nuclear factor kappa B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
... activation transcription factor 4; bp: base pairs; C/EBP: CCAAT/enhancer binding protein; ChIP: chromatin immunoprecipitation; DMEM: Dulbecco ’ s modified Eagle ’ s medium; FBS: fetal bovine serum; ...
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Characterization of the minute virus of mice P38 core promoter elements.
... activated transcription yet only low levels of basal expression, and we investigate the determi- nants that govern P38 basal ...P4 enhancer factor-binding sequences (nucleotides [nt] 57 to 157) ...
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Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1.
... From the results that Oct-1 can efficiently repress the HPV18 enhancer in HPV18-negative C33 cervical carcinoma cells as well as in primary human dermal fibroblasts, we conclude that Oct[r] ...
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Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo
... the transcription factor Foxh1 to regulate the Foxh1-dependent autoregulatory enhancer present in the Nodal locus; (2) Smad2 and Smad3 as well as Smad4 transcripts are expressed from the blastocyst ...
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Multiple protein-binding sites in an intracisternal A particle long terminal repeat.
... Three of the DNase I footprints include a sequence with homology to the simian virus 40 core enhancer and sequence motifs that closely resemble the binding sites for transcription factor[r] ...
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Hartl, Marion (2012): The genetic regulation of CO2 neuron formation in Drosophila melanogaster. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Embryos (UAS-Flag-Pros /X; actin-Gal4 /+) were collected and fixed as previously described (Sandmann et al., 2006). The embryos were fixed in a crosslinking solution (50mM HEPES, 1mM EDTA, 0.5mM EGTA, 100mM NaCl, pH 8,0) ...
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Molecular structure and transcriptional regulation of the gene for the platelet derived growth factor alpha receptor in cultured vascular smooth muscle cells
... responsible for this difference was narrowed to the sequence between -246 and -139, which enhanced the promoter activity of SHR fivefold over the basal activity. DNase I footprinting and gel-shift assay indicated that ...
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Dual roles of the bZIP transcription factor PERIANTHIA in the control of floral architecture and homeotic gene expression
... domain transcription factors of the SEPALLATA class (SEP1, SEP2, SEP3 and SEP4), which form tetrameric complexes with different combinations of homeotic ABC factors (Ditta et ...
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Identification of a Coronavirus Transcription Enhancer
... an enhancer activity similar to that described for other plus-stranded RNA viruses, such as Tombusvirus (26), in which this enhancer sequence (i) acts to stimulate the accumulation of an mRNA, (ii) ...
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Regulation of the Transcription and Replication Cycle of Human Cytomegalovirus Is Insensitive to Genetic Elimination of the Cognate NF-κB Binding Sites in the Enhancer
... HCMV transcription and/or replica- ...the enhancer do not play a major independent role in the transcription/replication strate- gies of HCMV in a variety of cell ...IE enhancer (9), the ...
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