transcription factor NF-?B
p38 Mitogen-Activated Protein Kinase-Dependent Hyperinduction of Tumor Necrosis Factor Alpha Expression in Response to Avian Influenza Virus H5N1
... necrosis factor alpha (TNF- ␣ ), in primary human macrophages in ...of transcription factor NF- B and cellular kinases in TNF- ␣ ...of NF- B or degradation of I ...
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Constitutive Activation of the Transcription Factor NF-κB Results in Impaired Borna Disease Virus Replication
... with NF- B activation were ex- amined by ...of NF- B was detected with an antibody directed against the phosphorylated p65 (RelA) subunit of the dimeric NF- B ...
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Transient Hemophagocytosis With Deficient Cellular Cytotoxicity, Monoclonal Immunoglobulin M Gammopathy, Increased T-Cell Numbers, and Hypomorphic NEMO Mutation
... The transcription factor NF- B regulates genes that are involved in inflammatory and immune responses, tu- morigenesis, and ...of NF- ...
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Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF-κB and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection
... that NF- B and IRF3 are crucial regulators of the CXCL10 response during early HCV in- fection in hepatocytes and that this response can be partially downregulated by AP-1 and C/EBP-  ...Other ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... growth factor starvation ...of transcription factor nuclear factor kappa B (NF-κB) in a subset of aged cells and plays a role in mediating inflammatory ...
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Series Introduction: The transcription factor NF κB and human disease
... of NF-κB is normally associated with induction of phosphorylation of IκB, followed by its degradation by the proteasome and nuclear translocation (2, ...Additionally, NF-κB reg- ulation involves ...
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Human Immunodeficiency Virus Type 1 Tat Protein Activates Transcription Factor NF-κB through the Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase, PKR
... nuclear factor- B (NF- B), acting through degradation of the inhibitor I B- ␣ ...Tat-mediated NF- B activation and transcriptional induction of the HIV-1 long ...
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Immunosuppressant FK506 induces interleukin 6 production through the activation of transcription factor nuclear factor (NF) kappa(B) Implications for FK506 nephropathy
... FK506 levels in whole blood (trough) and tissues, particularly in kidneys, after FK506 administration in mice to see what trough FK506 levels are observed, or whether tissue FK506 levels observed are comparable to FK506 ...
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Molecular mechanisms of HIV latency
... HIV transcription is reactivated so that antiretroviral therapy and the immune system clear the infection, has been proposed as one approach to curing ...viral transcription factors in such a way as to ...
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Estrogen, NFκB, and the Heat Shock Response
... E2, NF κ B and HSPs Previously, we have reported an inter- action among E2, NFκB, and the HSP re- ...either transcription factor negated the effects of E2 on HSP 72 expression ...
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Herpesvirus Saimiri STP-A Oncoprotein Utilizes Src Family Protein Tyrosine Kinase and Tumor Necrosis Factor Receptor-Associated Factors To Elicit Cellular Signal Transduction
... (pIRE), NF- B, Ets, C/EBP, AP-1, SP-1, and the retinoic acid response element ...45). NF- B has been reported to play a pivotal role in ICAM-1 gene regulation; for example, human T-cell ...
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Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression.pdf
... observed NF-kB activity in solid tumors, there is widespread observation of NF-kB activation in hematological malignancies (see Figure ...example, NF-kB activation and increased IKK activity are ...
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Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C.
... addition, TPA did not further stimulate CAT activity in cells cotransfected with pwtX and pKB-CAT data not shown, demonstrating the efficient activation of sequestered NF-KB by X protein[r] ...
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NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat
... promoter. Transcription factor overexpression assays revealed independent and synergistic upregula- tion of ERVK by interferon regulatory factor 1 (IRF1) and NF- B ...necrosis ...
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Identification of NF-κB-Dependent Gene Networks in Respiratory Syncytial Virus-Infected Cells
... inducible transcription factor nuclear factor B (NF- B) through proteolysis of its cytoplasmic inhibitor, I ...of NF- B-dependent genes induced by RSV ...
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Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B.
... TNF- b , IL-1 b , IL-2, IL-6, and GM-CSF genes are all target genes for the human transcription factor NF- k B ...conditions, NF- k B is released from I k B, ...
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Regulation of Proinflammatory Cytokine Expression in Primary Mouse Astrocytes by Coronavirus Infection
... four NF- B binding sites, a calcium- and cyclic-AMP-responsive element (CRE), and an AP-1 and Sp1 cis-binding site ...basal transcription of TNF- ␣ is controlled by Sp1, inducible expression of ...
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Anti Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis
... the transcription factor, nuclear fac- tor kappa B (NF-κB) ...[4]. NF-κB is most frequently com- posed of a p50 and a p65 subunit and under basal conditions it is retained in the ...
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Semen Exosomes Promote Transcriptional Silencing of HIV-1 by Disrupting NF-κB/Sp1/Tat Circuitry
... proviral transcription at multiple transcriptional checkpoints, in- cluding transcription factor recruitment to the long terminal repeat (LTR), tran- scription initiation, and ...human ...
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Herpesviruses and the Unfolded Protein Response
... primary B cells that differentiate into B cell tumors called primary effusion lymphoma (PEL) and present with a pre-plasma cell (or plasmablast) phenotype ...of B cells into non- dividing plasma ...
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