Transdifferentiation as a potential source for beta-cells
glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
... via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic ...alpha cells transdifferentiate into insulin-secreting beta cells following targeted ...
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Induction of differentiation of undifferentiated cells into pancreatic beta cells in vertebrates
... stem cells into pancreatic b -cells There are some problems with human ES cells, such as changes in the number of chromosomes as a result of repeated subculture, that do not arise with mouse ES ...ES ...
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Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
... therapeutic potential of transdiferentiation has led to attempts to direct the process towards functional ...liver cells which transitioned to pancreatic-beta-cell-like cells that helped ...
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Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation
... and potential epithelial ...epithelial transdifferentiation of the three subpopulations with subsequent analysis at the gene and protein ...levels. Transdifferentiation of the dif- ferent ...
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Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells
... The signaling pathways involved in fibroblast– myofibroblast transdifferentiation are complex and poorly understood so far. To the best of our knowledge, Smads sig- naling is considered the most important among ...
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Transdifferentiation of Human Dental Pulp Stem Cells Into Oligoprogenitor Cells
... stem cells are multipotent stem cells that can be considered as a new noninvasive autologous source for MSCs (Ghasemi et ...cell source for neuroregenerative ...multipotency potential ...
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Differentiation and transdifferentiation potentials of cancer stem cells
... the potential to transdifferentiate into stromal cells in tumor microenvironment, selectively targeting these CSC-derived cells may disrupt the CSC ...stromal cells may have a clinical benefit ...
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Transdifferentiation of human adipose-derived mesenchymal stem cells into oligodendrocyte progenitor cells
... stem cells (hADSCs) are a kind of adult stem cells which have a higher frequency in the fat tissue and have the ability to differentiate into other cell types outside their ...tumorigenic potential, ...
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Lost in transdifferentiation
... stem cells in human dis- ...Is transdifferentiation real or just an arti- fact? Is fusion a problem or is it a potential physiological mechanism to exploit? Are some tissues more susceptible to ...
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The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells
... the potential for growing tissues and organs in the laboratory and transplanting them when the body cannot heal ...the cells generated in vitro are typically of heterogenic and immature nature and the site ...
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DMRT1 Protects Male Gonadal Cells from Retinoid-Dependent Sexual Transdifferentiation
... for transdifferentiation in the testis when they are inappropriately activated by RAR ...granulosa cells in the fetal and postnatal ovary and Sertoli- to-granulosa transdifferentiation in the ...
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Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells
... tumor cells often exhibit only some of these changes, for example expressing a subset of mesenchymal markers while retaining epithelial features ...tumor cells to transit from an epithelial to ...
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Interleukin 1 beta induces the formation of nitric oxide by beta cells purified from rodent islets of Langerhans Evidence for the beta cell as a source and site of action of nitric oxide
... endocrine cells (beta-[insulin], alpha-]glucagon], gamma[somatostatin], and PP-[polypeptide] secreting cells) and non-endocrine cells (fibroblast, macrophage, endothelial, and dendritic ...the ...
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Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration
... into beta cell in the normal adult zebrafish raises the question whether similar plasticity exists for ...induce beta cell regeneration, we used the Tg(ins:NTR-mCherry) line [1] and treatment with ...
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Tgm2/Gh, Gbx1 and TGF beta are involved in retinoic acid induced transdifferentiation from epidermis to mucosal epithelium
... Direct transdifferentiation has been shown in exocrine cells to b -cells in adult mouse pancreas by transfection of 3 transcription factors after 3 days (Zhou et ...neuronal cells with long, ...
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Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells
... stromal cells [55,56], and MPCs have been recently shown to give rise to a fully functional population of B-cell supportive fibroblastic reticular cells (FRCs) [57], found associated with the follicular ...
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P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression
... the potential for EpSCs to transdifferentiate into MFLCs and that this mechanism is mediated by TGF β 1/Smad ...for transdifferentiation of EpSCs during cutaneous wound ...
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Detection of amplifiable mRNA extracellular to insulin producing cells: potential for predicting beta cell mass and function
... In conclusion, we have demonstrated that several healthy, proliferating insulin-producing cell lines in culture appar- ently pass many gene transcripts into the extracellular environment and that these transcripts can be ...
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Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells
... 832/13 cells The quench mode potentiometric measurement of rhodamine 123 has been widely used for qualitative and semi-quantitative determination of relative changes in ΔψM in β-cell research ...insulinoma ...
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Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment
... T cells and syn- oviocytes ...assist transdifferentiation of Tregs into Th17 cells with a potent osteoclastogenic phe- notype ...+ cells in RA patients on anti-TNF treatment and in healthy ...
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