Transforming growth factor, beta 3
The molecular basis of hypertrophic scars
... Transforming growth factor-β (TGF-β) plays a pivotal role in HTS formation TGF-β is one of the most im- portant growth factors that regulate tissue regeneration, cell differentiation, ...
12
Localisation of transforming growth factor beta(1) and beta(3) mRNA transcripts in normal and fibrotic human lung
... Briefly, 5 µm sections were cut and placed on slides previously coated with a 2% v/v solution of 3-aminopropyltriethoxysilane in acetone. After dewaxing, sections were rehydrated through a series of ethanol washes ...
8
Transforming Growth Factor Beta Is a Major Regulator of Human Neonatal Immune Responses following Respiratory Syncytial Virus Infection
... Differential regulation of the tgf-  1 gene in cord blood ver- sus adult cells in response to RSV infection was confirmed by real-time reverse transcription-PCR. The relative fold change of TGF-  1 after RSV infection ...
8
Safety study: is there a pathologic IGF-1, PDGF and TGF-ß cytokine expression caused by adjunct BMP-7 in tibial and femoral non-union therapy?
... like growth factor 1 (IGF-1), platelet-derived growth factor AB (PDGF-AB) and transforming growth factor beta (TGF-β) were compared between patients with the gold ...
7
expression with allergic rhinitis in children with obstructive sleep apnea hypopnea syndrome
... transcription factor T-bet and transforming growth factor beta 1 (TGF-β 1 ) in allergic rhinitis (AR) children with obstructive sleep apnea hypopnea syndrome (OSAHS) as well as their ...
11
Lysyl oxidase regulates transforming growth factor-[beta]1 function in bone
... Mineralization is a multifactorial process orchestrated by cells and a number of matrix molecules. In bone, fibrillar type I collagen regulates spatial aspects of mineralization by providing a 3-dimensional ...
137
Investigating the Role of Retinoblastoma Protein and Transforming Growth Factor-Beta in Growth Inhibition
... G1 growth arrest ...TGF-β1-induced growth inhibition and to ensure that shRNA targeting SAP30 transcript is not downregulating TβIIR level leading to growth arrest observed in knockdown experiment, ...
141
Pro-inflammatory activity of Astronium fraxinifolium Schott on Lipopolysaccharide-stimulated RAW 264.7 cells
... 2,2-azino-bis- 3-ethylbenzothiazoline-6-sulfonic ...necrosis factor alpha (TNF-α), and transforming growth factor beta (TGF-β) levels were determined in supernatants from ...
7
Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta
... Our experiments indicate that TGF b 1 exerts a differ- ential effect on profiling of gene expression in chondro- cytes according to the duration of treatment. A short TGF b 1 administration (1 hour) induces Sox9 ...
13
Transforming growth factor beta and breast cancer: Tumor promoting effects of transforming growth factor β
... lial growth factor, facilitation of basic fibroblast growth factor mediated capillary sprouting, inhibition of endothe- lial cell migration, and increased production of extracellular matrix, ...
8
Recombinant latent transforming growth factor beta 1 has a longer plasma half life in rats than active transforming growth factor beta 1, and a different tissue distribution
... Transforming growth factor beta 1 (TGF-beta 1) is a key regulator of cell growth and differentiation. Under normal physiological conditions, it is made as a biologically latent ...
10
Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells
... Figure 7 Biochemical analyses of mesenchymal stem cell aggregates following chondrogenic induction. Primary mesenchymal stem cells were infected with Ad.GFP (controls), Ad.IHH alone (IHH), or in combination with TGF- b 1 ...
13
Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
... The results of DIF for each group are shown in Figures 2, 3, and 4. In the healthy control group, few scattered CD14-TGF-b1 double-positive cells were observed (Figure 2). The number of cells increased ...
11
Influenza virus neuraminidase activates latent transforming growth factor beta.
... Western blot (immunoblot) analysis. Recombinant latent TGF- b (3 m g) was incubated in PBS alone (30 m l), in HCl (0.1 M in PBS), or with influenza virus (190 hemagglutinin [HA] units/30 m l) for 30 min at 37 8 C. ...
6
Regulation of transforming growth factor beta (TGFβ) at the level of nuclear entry
... Examination of TGFβR1 in the absence of TGFβR2 presents a more difficult problem. TGFβR1 alone does not bind ligand with strong affinity and its activation requires direct phosphorylation by TGFβR2 (Attisano 1998, Shi Y ...
323
Loeys-Dietz syndrome type I and type II: clinical findings and novel mutations in two Italian patients
... Mutations in the transforming growth factor (TGF) beta- receptor type I (TGFBR1) and type II (TGFBR2) genes have been found to cause LDS [1]. Mutations in these genes were also reported in ...
5
Transforming growth factor-beta receptor signalling is modulated by integrin-linked kinase
... of 3 days-old Ilk f/f mice (Terpstra et ...fibroblast growth medium (HyQ-DMEM-RS supplemented with 8% FBS, 100U/ml penicillin, and 100μg/ml streptomycin) was added and the cell suspension was then filtered ...
154
Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions
... Targeting EMT and MET may provide effective thera- peutics for cancer. However, therapeutic intervention may be complex because EMT occurs at an early stage of metastasis and MET occurs at later stages. MiRNAs that ...
11
Growth factors in idiopathic pulmonary fibrosis: relative roles
... of, growth factors, other mediators and ECM proteins (includ- ing enhanced collagen, TGF- β 1, matrix metalloproteinase- 9 and tissue inhibitor of metalloproteinase expression), giving them a profibrotic secretory ...
10
Extrinsic regulation of satellite cell specification
... hepatocyte growth factor), chemokine C-X-C motif receptor 4 (CXCR4), M-cadherin, neural cell adhesion molecule 1 (NCAM1), forkhead box protein K1 (Foxk1), integrin α7β1, CD34, and syndecans 3 and 4 ...
9