transmembrane domain (residues 400–662)
The Length of and Nonhydrophobic Residues in the Transmembrane Domain of Dengue Virus Envelope Protein Are Critical for Its Retention and Assembly in the Endoplasmic Reticulum
... the transmembrane domain (TMD) of E protein contains an ER retention ...nonhydrophobic residues at the N terminus of the first helix (T1) and at either the N or C terminus of the second helix of the ...
16
Structure and activation of the TSH receptor transmembrane domain
... lular domain (ECD) and a transmembrane domain ...N-terminal domain, a leucine- rich repeat domain (LRD) and a hinge region or cleavage ...
18
Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu
... from HeLa cells expressing FLAG-Ub and no Vpu or HA-tagged versions of wild-type Vpu, Vpu-S52,56N, or Vpu-W22L, with or without human CD4, were subjected to immunoprecipitation using an antibody to the HA peptide. ...
16
Helix-Destabilizing, β-Branched, and Polar Residues in the Baboon Reovirus p15 Transmembrane Domain Influence the Modularity of FAST Proteins
... -branched residues at the N terminus for ...minal residues in the p15 ...N-terminal residues of the p15 TMD are also  -branched amino ...-branched residues in the role of TMDs in membrane ...
13
Transmembrane domain interactions in carnitine palmitoyltransferase I
... A simplified model of membrane protein folding and complex formation, the “Two- Stage Model” proposed by Popot and Engelman (Figure 1.2), hypothesises that the final structure in the transmembrane region is ...
170
Residues in the Hendra Virus Fusion Protein Transmembrane Domain Are Critical for Endocytic Recycling
... Plasmids. Hendra virus F and G genes were kindly provided by Lin-Fa Wang of the Australian Animal Health Laboratory, and the genes were ligated into the pCAGGS mammalian expression vector (51) as previously described ...
13
Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility
... L41 residues plays a functional role in the determination of Vpu susceptibility, we tested these mutants for Vpu susceptibility and tetherin ...acid residues are highly conserved among primate tetherins and ...
14
Structural domains of the avian erythroblastosis virus erbB protein required for fibroblast transformation: dissection by in-frame insertional mutagenesis.
... In-frame insertions in the extracellular domain of the v-erbB protein, between the transmembrane domain and the kinase region, and in the extreme C terminus of this polypeptide did not a[r] ...
12
Charged Residues in the Transmembrane Domains of Hepatitis C Virus Glycoproteins Play a Major Role in the Processing, Subcellular Localization, and Assembly of These Envelope Proteins
... the transmembrane domain (TMD) is more than just an anchor to the ...hydrophobic residues separated by a short segment containing at least one fully conserved charged ...charged residues by an ...
11
Identification of the R1 Oncogene and Its Protein Product from the Rhadinovirus of Rhesus Monkeys
... Rhesus monkey rhadinovirus (RRV) is a gamma-2 herpesvirus that is most closely related to the human Kaposi’s sarcoma-associated herpesvirus (KSHV). We have identified a distinct open reading frame at the left end of RRV ...
9
Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion.
... the domain of the HN protein which interacts with the F protein in a type-specific manner, a series of chimeric HN proteins between two different paramyxoviruses, Sendai virus (SN) and human parainfluenza virus ...
7
Isolation and characterisation of the Drosphila dror2 gene : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Palmerston North, New Zealand
... Dror encodes a 685 ammo acid mature receptor protein comprising an extracellular domain containing a cystcine rich region and a kringle domain, a hydrophobic transmembrane domain and a c[r] ...
163
Mutations in the membrane-spanning domain of the human immunodeficiency virus envelope glycoprotein that affect fusion activity.
... Subsequent mutagenic analysis of the HIV-1 Env transmembrane domain revealed that the sequence of amino acid residues from positions 696 to 707 of the transmembrane domain was important [r] ...
5
Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association In Vitro
... M embrane fusion is a critical event in the life cycle of enveloped viruses. Fusion of the viral envelope with the target cell membrane is mediated by the viral fusion protein. The trimeric fusion protein undergoes a ...
6
Site-specific mutagenesis identifies three cysteine residues in the cytoplasmic tail as acylation sites of influenza virus hemagglutinin.
... Likewise, cystein residues of the transmembrane domain are still acylated, if they are only one human class I histocompatibility antigen B7, respiratory syncytial virus F protein, and tr[r] ...
10
Arbovirus Structure and Interaction with Host Cells.
... transmembrane domain and its role in viral assembly and infectivity (Whitehurst et ...the transmembrane region with single to multiple amino acid deletions that encompass the entire helical face ...
123
Toxicological analysis on EGFR Protein Inhibitors (Clerodane and Iressa 2) using TOPKAT analysis
... a transmembrane receptor with an extracellular ligand-binding domain, a helical transmembrane domain, and an intracellular tyrosine kinase ...extracellular domain is the first step in a ...
5
Length Requirements for Membrane Fusion of Influenza Virus Hemagglutinin Peptide Linkers to Transmembrane or Fusion Peptide Domains
... of residues involved in deletion mutants and the locations at which inserted pairs of amino acids were ...structure. Residues between residues 106 and 112 form a loop in low-pH HA that inverts the ...
12
HER2 therapy HER2 (ERBB2): functional diversity from structurally conserved building blocks
... Instead, recent studies conducted by Kuriyan and colleagues [38] show that EGFR kinase domains achieve allosteric activation by assuming a dimeric packing mode that resembles interactions observed in the CDK2/cyclin A ...
8
Elucidating the Energetics of Bacterial Signal Transduction: Insights From Phoq
... The piston model (Fig. 1.9.B, left), which was based on the chemoreceptor Tar (Chervitz and Falke, 1996), proposes that ligand binding generates an ~1 Å piston-like downward displacement in the p-helix that propagates ...
133