transport and efflux
Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging
... aberrant transport and clearance of Aβ peptides across the BBB, mediated by a spectrum of receptors and transporters including RAGE, LRP-1, and members of ABC family, contributes to Aβ accumulation in the brain ...
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Voluntary exercise increases cholesterol efflux but not macrophage reverse cholesterol transport in vivo in mice
... cholesterol efflux and in vivo reverse cholesterol transport ...cholesterol efflux towards plasma was significantly increased in running (n = 8) compared to sedentary (n = 6) mice ...cholesterol ...
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Ethylene inhibits lateral root development, increases IAA transport and expression of PIN3 and PIN7 auxin efflux carriers
... and efflux activity in ACC suppression of LRP development: auxins that bypass auxin influx carriers, inhibitors that are selective for influx and efflux carriers, and a diversity of auxin transport ...
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Possible Factors Involved in Oral Inactivity of Meropenem, a Carbapenem Antibiotic
... for efflux transporters such as MDR1, multidrug resistance-associ- ated protein 2 (MRP 2, ABCC2) or breast cancer resis- tance protein (BCRP, ABCG2), located on the brush- border membranes of ...an efflux ...
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Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography
... Sequencing studies have identified molecular alter- ations in brain tumors which may constitute promising targets for their treatment with molecularly targeted an- ticancer drugs [4]. However, small-molecule inhibitors ...
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Journal of Applied Pharmaceutical Science
... MTX transport in membrane vesicles isolated from cells overexpressing the proximal tubular apical efflux transporters human multidrug resistance protein (MRP2 and MRP4) and found that a wide variety of ...
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Thyroid hormones stimulate calcium transport systems in rat intestine
... + efflux from intestinal cells is known to occur through the Na + /Ca 2 + ...+ efflux from intestinal cells varied in parallel to the thyroid hormones levels ...
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Original Article Permeability of rhynchophylline across human intestinal cell in vitro
... and efflux screening in vitro during the development of oral ...the transport of drugs across the intestinal epithelium, actively or passively, and, if the transport is active, to identify the rel- ...
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Efflux Pump Inhibitors Derived From Natural Sources as Novel Antibacterial Agents Against Pseudomonas aeruginosa: A Review
... Drug Efflux Pumps and Pathway of Drug Efflux Across the IM and OM in Pseudomonas ...aeruginosa. Efflux transporters in ...drug transport. MFP is MexA and links the OMP and the IMP. These ...
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Absorption intestinale des vitamines liposolubles
... a efflux, comme les transporteurs ABCG5 et G8 (Iqbal et Hussain, 2009), initialement impliqu es dans le transport inverses du cholest erol et des phytost erols, partici- pent a ce ph enom ene dans le cas ...
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Ozone Impacts on Carbon Dynamics in Cotton
... of efflux of photoassimilate; (B) the calculated pool of labile, transport carbohydrate; (C) the rate constant for the slow phase of efflux of photo- assimilate; and (D) the calculated pool of slowly ...
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Calcium and phosphate transport in isolated segments of rabbit Henle's loop
... equation. When ouabain was added to the bath the potential difference fell to +1.1 +/- 0.3 mV, whereas the calcium efflux was only slightly diminished (29.5 +/- 5.3-23.7 +/- 5.1 peq- cm-1-min-1). Ouabain had no ...
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Dynamic, auxin responsive plasma membrane to nucleus movement of Arabidopsis BRX
... directional transport of the phytohormone auxin, known as polar auxin transport (PAT) (Men et ...auxin efflux carriers, the PIN-FORMED (PIN) proteins (Wisniewska et ...as TRANSPORT INHIBITOR ...
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High-throughput screening of excipients with a biological effect : a kinetic study on the effects of surfactants on efflux-mediated transport
... mediated transport and ABCC2-mediated transport using the Caco-2 cell line in this novel high-throughput system, with the aim of modelling such materials as drug–drug ...
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An Update on Plant-Derived Compounds as Potential Inhibitors of the Bacterial Efflux Pumps: With Reference to Staphylococcus aureus and Escherichia coli
... bacterial efflux pump systems. They are important transport proteins, mainly involved in the removal of toxic substrates like antibiotics from inner cell ...of efflux pumps are present in the ...
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Real-time PCR and real-time RT-PCR applications in food labelling and gene expression studies
... Purpose Species Tissue Gene Reference P-glycoprotein in sheep liver and small intestine gene expression and transport efflux activity Sheep Liver ABCB1 [21] Analysis on cDNA sequence, mR[r] ...
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Saccharomyces cerevisiae Vacuolar H+-ATPase Regulation by Disassembly and Reassembly: One Structure and Multiple Signals
... proton transport, readdition of glucose activates the plasma membrane ATPase, Pma1p, which is the main efflux pump responsible for yeast cytosolic pH regulation (83, ...
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Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport
... cDNAs encoding anti-PIN1 scFv fragments were constructed after reverse transcription of mRNA encoding short-chain antibody frag- ments from hybridoma cell cultures was amplified using the following primers: heavy chain ...
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A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Infers How Plant Sterol Intake Reduces Circulating Cholesterol Levels
... BBM and lumen promotes cholesterol efflux, and plant sterol in the BBM may disturb the trafficking 25.. machineries that transport cholesterol to the cell interior.[r] ...
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Liver X receptors as integrators of metabolic and inflammatory signaling
... transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated in response to elevated intracellular cholesterol levels in multiple cell types. Once activated, LXRs induce ...
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