tricarboxylic acid cycle
An inherited defect affecting the tricarboxylic acid cycle in a patient with congenital lactic acidosis
... hydratase appeared normal. The binding of citrate to aconitate hydratase and the activities of the NAD- and NADP-linked isocitrate dehydrogenases were also normal, while the activity of citrate synthase was slightly ...
8
Structural Basis for the Interaction of 14 3 3β with Tricarboxylic Acid Cycle Intermediate Malate
... a Tricarboxylic Acid Cycle intermediate Malte bound ...citric acid cycle through acetyl-CaA formed during oxidation of fatty ...
12
Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets
... the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli and Mycobacterium tuberculosis, and studied the effects of inhibition of various enzymes in the ...
11
Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using (1)H-[(13)C] MRS and fMRI
... utilization; tricarboxylic acid cycle flux; human visual cortex; hemifield visual stimulation; 1 H-{ 13 C} MRS; functional MRI; neuronal activity Minimally invasive or noninvasive imaging techniques, ...
7
THE EXCRETION OF l MALIC ACID IN RELATION TO THE TRICARBOXYLIC ACID CYCLE IN THE KIDNEY
... 21, Table II, were re- peated and rates of malate filtration, excretion and reabsorption during l-malate infusion were mea- sured over a wide range of plasma malate levels.. The massed d[r] ...
11
Development and Characterization of a Condensed Reverse Tricarboxylic Acid Cycle for Use in Plants.
... aboard the last Space Shuttle flight, STS-135. It was truly an honor and a highlight of her career. While in this position, Caroline was accosted at a Fresh Market by professors and convinced to enter a Ph.D. program. ...
200
Tricarboxylic acid cycle enzymes and bicarbonate fixation in morphogenesis of Blastocladiella emersonii.
... Moreover, the Qn of RS is much lower than that of OC 2 plants. These results were considered as evidence in support of the hypothesis that bicarbonate first reversed the flow then induced multiple enzymatic lesions in ...
63
Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
... a Department of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts, USA b Biological Sciences, Pacific Northwest National Laboratory, Richland, Washington, USA c Department of ...
10
Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates
... The reaction was quenched with 1% formic acid at defined time points. The samples were then mixed in 1:1 ratio with α-cyano-4-hydroxycinnamic acid ma- trix and spotted onto a MALDI target plate. Spectra ...
12
Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum
... xylic acid (TCA) cycle, which provides several metabolic precursors and cofactors for cell growth and amino acids production ...TCA cycle, such as phos- phoenolpyruvate (PEP)-pyruvate-oxaloacetate ...
13
A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β Lactam Stress
... citric acid cycle (tricarboxylic acid [TCA] ...citric acid cycle ...TCA cycle dysfunctions presumably as a way to tolerate these ...TCA cycle, including increased ...
6
Analysis of organic acids of tricarboxylic acid cycle in plants using GC-MS, and system modeling
... 3rd cycle (when the first formation of fumaric acid would occur) to the 12th cycle, was used to estimate the rate transfer coefficients of the difference equations (Table ...succinic acid, ...
9
Genetic and Biochemical Interactions Involving Tricarboxylic Acid Cycle (TCA) Function Using a Collection of Mutants Defective in All TCA Cycle Genes
... TCA cycle suggesting that NAD-IDH mtRNA binding plays a subtle enzymes, it is possible that they may encode functions role in mitochondrial ...TCA cycle func- clear how defects in another TCA cycle ...
14
Comamonas testosteroni uses a chemoreceptor for tricarboxylic acid cycle intermediates to trigger chemotactic responses towards aromatic compounds
... This result clearly indicated the ligand binding was essen- tial for triggering chemotactic responses with MCP2201. The McpS chemoreceptor from P. putida restores chemotaxis of CNB-1 Δ20 towards aromatic compounds Based ...
11
Genetic Evidence for Two Carbon Fixation Pathways (the Calvin-Benson-Bassham Cycle and the Reverse Tricarboxylic Acid Cycle) in Symbiotic and Free-Living Bacteria
... lic acid (rTCA) and the Calvin-Benson-Bassham (CBB) cycles, such as symbiotic, sulfur- oxidizing bacteria that are the sole carbon source for the marine tubeworm Riftia pachyptila, the fastest-growing ...rTCA ...
7
Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction
... amino acid and carbon source limitations (23). Using LB broth, amino acid limitations are unlikely at early growth ...TCA cycle intermediate as carbon source is ...
18
Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle
... production. Combining these genetic manipulations achieved a maximum SAM titer of 67.41 mg/L using the resulted strain HSAM1, a 1.42-fold increase com- pared with strain HZ-12. Transcription and metabolite analyses ...
12
Nutritional Intervention with Tricarboxylic Acid Cycle Intermediates Modulates Mitochondrial Flux and Respiratory Chain Complex Abundance in C2C12 Myoblast Cells
... malic acid, when provided as single component additions, to the cells produced significantly lower extracellular lactate levels than glucose (p ≤ ...pyruvic acid was directly supplied to myocytes, indicated ...
8
Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury.
... TCA cycle intermediates, and amino acids were elevated in the vehicle control groups 24 h after reperfusion compared to baseline, suggesting that they could serve as biomarkers of reperfusion injury [ 43 ...
15
Monolayers of biphenyl 3,4',5 tricarboxylic acid formed on Cu and Ag from solution
... For the discussion of possible configurations we refer to Figure 11a, which displays different arrangements and conformations of the molecules and schematic representations of the corresponding unit cells. Structure i ...
41