Triple (ER/PR/HER2)-negative breast cancer
The clinical promise of immunotherapy in triple-negative breast cancer
... Abstract: Triple-negative breast cancer (TNBC) is a heterogeneous disease with poorer outcomes compared to other breast cancer ...lung cancer, melanoma, and bladder ...
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Roles of eIF3m in the tumorigenesis of triple negative breast cancer
... Background: Without targets, triple negative breast cancer (TNBC) has the worst prognosis in all subtypes of breast cancer (BC). Recently, eukaryotic translation initiation ...
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Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway
... Breast cancer is one of the most widespread carcinoma and one of the main causes of cancer-related death worldwide, especially in women aged between 35 and 75 ...subtypes, triple ...
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Triple negative breast cancer
... both ER and proges- terone receptor. HR-negative tumors are accompanied by a high histologic ...basal-like breast carcinomas [1] by gene expression analysis as well as protein expression ...
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Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer
... Breast cancer (BC) is the most frequent female cancer, and is a complex and heterogeneous ...the HER2 oncogene) and basal-like breast cancer (BLBC, expressing genes specifically ...
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Correlation of Breast Cancer Subtypes Based on ER, PR and HER2 Expression with Axillary Lymph Node Status
... that HER2 over expression could be the most important defining factor for ALN metastasis among these three ...where HER2 expression had the strongest predictive value for ALN metastasis (Wald Chi ...by ...
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Clinicopathological, therapeutic and prognostic features of the triple negative tumors in moroccan breast cancer patients (experience of Hassan II university hospital in Fez)
... Triple-negative breast cancer (TNBC) is defined as a group of breast carcinomas that are negative for expres- sion of hormone receptors (ER, PR) and HER2, we ...
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Real-world efficacy and safety of eribulin in advanced and pretreated HER2-negative breast cancer in a Spanish comprehensive cancer center
... advanced breast cancer (ABC) ...with triple-negative breast cancer (TNBC) or HER2-negative disease, in patients with > 2 organs involved and in patients with ...
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Molecular Subtypes of Ductal Carcinoma In Situ (DCIS) Identified by Expression of ER, PR, HER2, and Ki-67
... of ER, PR, HER2, and Ki-67, breast cancer patients were classified into the five molecular subtypes: luminal A, luminal B/HER2 negative, luminal B/HER2 positive, ...
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Occurrence of breast cancer subtypes in adolescent and young adult women
... older breast can- cer ...of breast cancer, especially triple-negative breast cancer [7,8], in young Blacks and relatively lower rates with increasing age for Hispanic and ...
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Thesis
... of breast cancer heterogeneity have been made by Perou et ...of breast tumors, each with distinct prognosis and risk indicators that are defined by differential gene ...of breast cancer ...
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Environmental radon exposure and breast cancer risk in the Nurses’ Health Study II
... for breast cancer ...invasive breast cancer risk by hormone receptor status (ER+; ER-; ER +/PR+; ER − /PR-; ER+/PR-; ER − ...
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Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium.
... triage; negative results may be considered final, whereas positive results require vis- ual ...to ER-negative or triple negative (ER2/PR2/HER22) cancers express- ing basal ...
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Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups
... that breast cancer sub- types should be considered separately, it is still routine to present statistics that consider the disease as a single ...in breast cancer ...specific breast ...
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Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors
... the triple negative (TNBC) and HER2+ subtypes of breast cancer [3, ...of breast cancers during metasta- sis [5, 6], very little is known about the co-evolution of immune cells ...
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Profiling molecular regulators of recurrence in chemorefractory triple negative breast cancers
... copy number changes, including high-level focal amplifi- cations, were acquired during the course of chemother- apy. However, we detected no correlation between clonal evolution and recurrence. Our observations are ...
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Original Article Clinicopathological classification and traditional prognostic indicators of breast cancer
... [1]. Breast cancer is classified into 5 subtypes using the expression of four markers (estrogen receptor (ER), proges- terone receptor (PR), human epidermal growth factor receptor-2 ...
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Case Report Dedifferentiation-like progression of breast carcinoma: report of a case showing transition from luminal-type carcinoma to triple-negative carcinoma with myoepithelial features
... of breast carcinoma revealed that the basal-like subtype expresses genes characteristic of basal/myoepithelial cells, while the luminal subtype expresses genes characteristic of luminal mammary epi- thelial cells ...
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Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes
... against cancer [22], currently, there is increasing interest worldwide on the role played by Heat Shock Proteins (HSPs) in cancer development and the ability of anti-carcinogenic natural compounds and other ...
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Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer
... The low prevalence of IBC, and the small size of diag- nostic biopsy specimens have been obstacles in under- standing of IBC pathogenesis. To date, current treatments are based on multimodal approaches, are non-specific ...
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