Tris(2-ethylhexyl)phosphate
Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia
... We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, ...
12
Ambient C1 ions modify rat mesangial cell contraction by modulating cell inositol trisphosphate and Ca2+ via enhanced prostaglandin E2
... mesangial cells showing contraction responding to AII and AVP was decreased from 72 +/- 9 to 33 +/- 10% and from 60 +/- 4 to 24 +/- 11%, respectively. Ca2+ transients induced by AII and AVP, measured in mesangial cells ...
8
Portraying the effect of source influx on interdependent calcium and inositol 1,4,5−trisphosphate dynamics in cardiac myocyte
... Abstract. Calcium governs the most versatile and universal signaling mechanism in living systems which includes contraction of the cardiac tissues, information processing in the brain, release of digestive enzymes by the ...
17
Maturational regulation of inositol 1,4,5 trisphosphate metabolism in rabbit airway smooth muscle
... phosphoinositide-linked signal transduction, we examined whether age-related differences in tracheal smooth muscle (TSM) contractility to carbachol (CCh) are associated with developmental changes in the production and ...
8
Interactions Between the Inositol 1,4,5-Trisphosphate and Cyclic AMP Signaling Pathways Regulate Larval Molting in Drosophila
... Larval molting in Drosophila, as in other insects, is initiated by the coordinated release of the steroid hormone ecdysone, in response to neural signals, at precise stages during development. In this study we have ...
10
Endothelin B receptor Ca2+ signaling in shark vascular smooth muscle: participation of inositol trisphosphate and ryanodine receptors
... 1,4,5- trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry ...
7
Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy
... Autophagy is an important cell-biological process responsible for the disposal of long-lived proteins, protein aggregates, defective organelles and intracellular pathogens. It is activated in response to cellular stress ...
9
Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos
... The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis II (MII)-arrested mouse eggs is characterized by ...
14
norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5) trisphosphate receptor in Drosophila melanogaster renal function
... and itpr, encoding inositol 1,4,5-trisphosphate receptor Measurements of cytosolic calcium levels in intact IP3R, both attenuate response to diuretic peptides of tubules of wild-type and[r] ...
11
Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy
... 1,4,5- trisphosphate type 1 receptor; MoL: Molecular layer; MRC: Medical Research Council scale; NMOSD: Neuromyelitis optica spectrum disorders; PBMC: Peripheral blood mononuclear cell; PBS: Phosphate buffered ...
17
Inositol 1,4,5 trisphosphate binding proteins controlling the phototransduction cascade of invertebrate visual cells
... dependent phosphorylation of cephalopod opsin has been reported (Kikkawa et al., 1998; Paulsen and Hoppe, 1978; Vandenberg and Montal, 1984b; Tsuda et al., 1989). In the vertebrate system, work with transgenic mice has ...
7
Enhanced inositol trisphosphate response to alpha 1 adrenergic stimulation in cardiac myocytes exposed to hypoxia
... inositol trisphosphate was quantified by a novel procedure developed in our laboratory that circumvents problems associated with using labeled ...inositol trisphosphate levels of three- to fourfold were ...
6
Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5 Trisphosphate Homeostasis
... Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5 Trisphosphate Homeostasis Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,[.] ...
15
Neuropathologic Role of Inositol (1,4,5)-Trisphosphate Receptor Proteolysis
... cardiac arrest targets early reperfusion and restoration of blood flow, as the severity of neurological injury depends on the duration of ischemia. Periods of ischemia that are sufficient to trigger depolarization of ...
166
Chronic ethanol administration to rats decreases receptor operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5 inositol trisphosphate production: relevance to impaired liver regeneration
... We tested the hypothesis that ethanol impairs liver regeneration by abrogating receptor- mediated elevation of cytosolic free calcium ([Ca2+]i). In rats fed for 16 weeks with ethanol, hepatocellular proliferation induced ...
9
The redistribution of Ca2+ stores with inositol 1,4,5 trisphosphate receptor to the cleavage furrow in a microtubule dependent manner
... Mitsuyama5 pm Original Article The redistribution of Ca2+ stores with inositol 1,4,5 trisphosphate receptor to the cleavage furrow in a microtubule dependent manner FUYUKI MITSUYAMA* and TSUYOSHI SAWA[.] ...
8
Regulation of inositol 1,4,5 trisphosphate kinase activity after stimulation of human T cell antigen receptor
... The addition of T3/Ti MAbs to Jurkat cells induces substantial increases in InsP3 and concentration of cytoplasmic free calcium [Ca2+]i and stimulates the translocation of protein kinase[r] ...
5
Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling : mitochondrial control of endothelial Ca2+ signaling
... i, composite Ca2⫹ images illustrating Ca2⫹ activity in the same field of endothelial cells during a 1-min period before left and after right pharmacological intervention; each image pair[r] ...
23
Inositol 1,4,5 trisphosphate may regulate rat brain Cai++ by inhibiting membrane bound Na(+) Ca++ exchanger
... To determine if 1,4,5-IP3 may regulate cell cytosolic Ca++ by acting on plasma membrane bound Na+-Ca++ exchanger, we investigated Ca++ transport in synaptosomes using 45Ca++ as tracer.. [r] ...
6
Pregnancy block by MHC class I peptides is mediated via the production of inositol 1,4,5 trisphosphate in the mouse vomeronasal organ
... Exposure of C57BL/6 female mice mated with BALB/c males to urine of castrated or juvenile C57BL/6 males resulted in a significant pregnancy failure rate, whereas, exposure to urine of BA[r] ...
7