Tumor-Infiltrating
Collagen density regulates the activity of tumor-infiltrating T cells
... the tumor microenvironment, which includes stromal cells, immune cells, and the extracellular ...of tumor-infiltrating T cells reflects the abil- ity of the immune cells to mount a response against ...
15
Characterization of tumor infiltrating Natural Killer cell subset
... Tumor infiltrating Natural Killer (NK) lymphocyte cells, that are part of the innate immune system, have the ability to both lyse cells lacking major- histocompatibility-complex (MHC) proteins and to ...
9
Clinical significance of tumor-infiltrating lymphocytes in breast cancer
... Tumor infiltrating lymphocytes (TIL) play an essential role in mediating response to chemotherapy and improving clinical outcomes in all subtypes of breast ...+ tumor infiltration or increased type 1 ...
7
Original Article Tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in pretherapeutic breast cancer core biopsies: Anti-tumoral effect of immune cells associated with neoadjuvant chemotherapy
... between tumor-associated macrophages (TAMs) or tumor-infiltrating lymphocytes (TILs) and short-term response to neoadjuvant chemotherapy (NAC), we analyzed TAM/TILs in pre-NAC breast cancer core ...
9
Pure Choriocarcinoma of Testis with Tumor Infiltrating Lymphocytes and Granulomas
... including tumor infiltrating lymphocytes are unusual in ...The tumor cells were positive for cytokeratin 7, epider- mal growth factor receptors, human placental lactogen and ...the tumor. The ...
5
Evaluation of tumor infiltrating lymphocytes in breast cancer
... between Tumor Infiltrating Lymphocytes and different clinic-pathological parameters like age group, size, side, histopathology, grade, lymph node status, Neo adjuvant chemotherapy, Hormonal receptors like ...
139
Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes
... includes tumor specimens from 86 patients collected between 1982 and 2009 at a single ...benign tumor (p=0.043). We also observed that only 9 out of 53 MPNST tumor specimens had expression of PD-L1, ...
9
Tumor-infiltrating CD4+ T cells in patients with gastric cancer
... of tumor-infiltrating Tregs have shown poor outcomes [23, ...among tumor-infiltrat- ing CD4 + T-cells were favorable, but they only analyzed ...
12
Tumor infiltrating B cells are increased in prostate cancer tissue
... the tumor microenvironment, that elicit leukocyte recruitment, including B cells, that promote PCa recurrence ...the tumor infiltrating B cells produce lymphotoxin (LT), a heterotri- meric cytokine ...
9
Relevance of tumor-infiltrating lymphocytes in breast cancer
... of tumor cells to antibody dependent cytotoxicity (ADCC) [67, 69] (reviewed by ...residual tumor at surgery post-NAC and anti-HER2 therapy had the worst outcomes of all, suggesting that it is this group ...
13
The prognostic value of tumor infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: a systematic review and meta analysis
... prognosis in colorectal cancer [6–9]. Several immune cells contribute to an effective immune response, CD8+ T cells of TILs serve as cytotoxic effects, whereas CD4+ T helper cells (CD4+Th) promote clonal expansion of ...
11
High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients
... University and 184 Breast Cancer Tissue was acquired from patients in Sun Yat-sen University cancer center, who had undergone surgical resection and had been diagnosed with TNBC. 215 samples (including recurrent and ...
8
Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer
... CRC is the third most common cancer in women and the fourth most common in men worldwide [1]. Incidence of and mortality from CRC are increasing in China in recent years. Although the clinical management for CRC has ...
12
Gene expression markers of Tumor Infiltrating Leukocytes
... We have identified a set of marker genes with sufficient cell type specificity that their expression levels can be used to measure immune cell subpopulations in the tumor microenvironment. The quality of available ...
15
Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance
... of tumor pathologic features ...in tumor with MMR defects by T-cells, macrophages, and natural killers, infiltration might be increased enhancing immune surveillance mechanisms ...of tumor ...
11
Original Article PD-L1 is correlated with p53 expression in patients with lung adenocarcinoma
... in tumor-infiltrating immune ...in tumor-infiltrating immune cells was more fre- quent in male patients, solid predominant tu- mors and poor differentiation, and showed a significant ...
13
The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
... each tumor area indicated that IM and IT were the major infiltrating areas of T cells ...each tumor area also indicated that IM and IT showed com- paratively high PD-L1 expression, while N and TR had ...
13
Lack of MICA Expression Predicts a Worse Prognosis in Patients with Bladder Cancer
... cancer. Tumor- infiltrating NKG2D+ lymphocytes were present in a small proportion of these ...with tumor destruction is a major goal of cancer ...to tumor regressions in the context of ...
10
Stratification of ovarian tumor pathology by expression of programmed cell death-1 (PD-1) and PD-ligand- 1 (PD-L1) in ovarian cancer
... primarily tumor infiltrating lympho- cytes (TILs), with varying degrees of intensity of staining and frequency of occurrence of these ...the tumor microenvironment, thus we scored this stain in two ...
11
CONGENITAL MESOBLASTIC NEPHROMA OF INFANCY
... Note the bands of tumor infiltrating the kidney parenchyma at the.. top.[r] ...
9