Tumor Suppressor Gene
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
... Ras-related tumor suppressor gene aplasia Ras homolog member I (ARHI; also known as DIRAS3) is downregulated in more than 60% of ovarian cancers, and here we show that re-expression of ARHI in ...
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The putative tumor suppressor gene EphA7 is a novel BMI-1 target
... a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and ...putative tumor suppressor gene EphA7 as a novel direct BMI-1 ...
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Identification of synaptotagmin XIII as a liver tumor suppressor gene
... the gene-containing portion of the human genome had been sequenced with ...candidate gene approach to identification of putative liver tumor suppressor genes using our MCH model ...11p11.2 ...
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Arsenic exposure is associated with DNA hypermethylation of the tumor suppressor gene p16
... Despite significant efforts to eliminate arsenic from in- dustrial processing and agricultural use, occupational and environmental exposures to toxic levels of arsenic are still common in developing countries. Therefore ...
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Alterations of tumor suppressor gene p16 INK4ain pancreatic ductal carcinoma
... of tumor suppressor gene p16 have been reported in a variety of human tumors but less informa- tion is available regarding alterations of p16 in primary pancreatic ductal carcinoma than in pancreatic ...
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ARID2: A new tumor suppressor gene in hepatocellular carcinoma
... PBRM1 gene in renal clear cell carcinomas ...in tumor genesis is BRD7. The BRD7 gene is frequently deleted in the breast cancers with wild-type p53 ...hSNF5/INI1 gene which encodes a subunit ...
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Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas
... solid tumor of ...of tumor-derived cell lines, representing one of the most characteristic genomic changes in NBs ...a tumor suppressor gene (TSG) from this ...
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Tumor Suppressor Gene p53 status in Upper Gastro Intestinal Malignancies
... There is also mounting evidence that numerous, specific regions throughout the genome are frequently lost in these cancers. The study of the p53 tumor suppressor gene has blossomed into a field of ...
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Detection of doublecortin domain-containing 2 (DCDC2), a new candidate tumor suppressor gene of hepatocellular carcinoma, by triple combination array analysis
... candidate tumor suppressor gene in ...this gene in carcinogenesis are required to confirm this gene as a bona fide tumor ...this gene correlated with overall ...inhibit ...
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Isolation and characterization of novel RECK tumor suppressor gene splice variants
... RECK tumor suppressor gene, namely: RECK-B (1,548bp) and RECK-I (1,101bp), were identified and isolated by RT-PCR and their expression profiles were investigated using quantitative real time PCR ...
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TCF4 MAY ACT AS A TUMOR SUPPRESSOR GENE IN COLORECTAL CARCINOGENESIS
... processes, including proliferation, differentiation, survival, apoptosis and cell motility [21] and also regulates cell adhesion, morphology, proliferation, migration and structural remodeling [22,23] . TCF4 is a ...
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Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer
... recessive gene, inactivation of an allele does not necessarily compromise its function entirely, as it can express itself partially ...this gene in GBC measured using different molecular ...
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Tumor suppressor gene E-cadherin and its role in normal and malignant cells
... (E)-cadherin gene CDH1 maps to chromosome ...length gene by using recombinant lambda phage, cosmid and P1 phage ...The gene they cloned encompasses 16 exons and spans a region of ~100 ...the ...
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mMaspin: The Mouse Homolog of a Human Tumor Suppressor Gene Inhibits Mammary Tumor Invasion and Motility
... These data have demonstrated that mMaspin functions to inhibit mouse mammary tumor cell invasion and motility, just as human maspin in- hibits human mammary carcinoma cells, sug- gesting[r] ...
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Expression of the Arf tumor suppressor gene is controlled by Tgfβ2 during development
... using an antibody recognizing Smad2 and Smad3 is described to show Smad binding at promoters like that driving mouse Id1 expression (Smith et al., 2009). In our experiments, Smad2/3 binding was evident at baseline levels ...
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Early Detection is as Important as Imatinib in CML Treatment Success
... the tumor it is possible that a new sub-clone was formed which is no longer completely dependent on any single founder ...of gene effected by first driver mutation will likely have implication on degree of ...
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Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation
... a tumor suppressor gene in which mutations are typically found in sporadic cancers and inherited tumor sus- ceptibility conditions, such as the PTEN hamartoma tumor syndrome ...
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Original Article FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells
... with tumor suppressor gene silenc- ing in ...controlling gene CpG island methylation in breast ...these tumor suppressor genes, whereas over-expression of FOXA1 showed the ...
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Loss of Heterozygosity at the Ink4a/ArfLocus Facilitates Abelson Virus Transformation of Pre-B Cells
... In many instances, loss of one copy of a tumor suppressor gene is accompanied by mutation of the second copy. To de- termine if mutations affecting p19Arf sequences were common in transformants ...
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Epigenomics: Genome-Wide Study of Methylation Phenomena
... with gene expression. Knudson’s “two hit” hypothesis of tumor generation assumes that for full inactivation of a tumor suppressor gene, two independent inactivating events are required; ...
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