Tumor Suppressor Genes
Submicroscopic deletion of 5q involving tumor suppressor genes (CTNNA1, HSPA9) and copy neutral loss of heterozygosity associated with TET2 and EZH2 mutations in a case of MDS with normal chromosome and FISH results
... heterozygosity (LOH) is an indicator of neoplastic evo- lution and disease progression [12,13]. Copy-neutral LOH (cnLOH) arises either via a hemizygous deletion in one homolog and duplication of the other, or uniparental ...
9
Cooperative Effects of Tumor Suppressor Genes and Oncogenes on the Dynamic Process of Tumorigenesis
... "floxed" tumor suppressor gene in a tissue-specific manner so that only mammary cells become predisposed to cancer ...p53 tumor suppressor genes in mammary epithelial cells ...
326
Evidence that DNA repair genes, a family of tumor suppressor genes, are associated with evolution rate and size of genomes
... on genes that are related with disease, since evolutionary studies may contribute to a better under- standing of the function of those ...repair genes, one of the most important categories of tumor ...
10
In Silico Analysis of the Protein Structure of Tumor Suppressor Genes in Humans
... BRCA2 genes, are the Alpha helix (Hh), Extended Strand (Ee) and Random coil (Cc), with differing number of ...of tumor suppressor genes are represented in figure ...of tumor ...
6
Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma
... HB-associated tumor suppressor genes (TSGs) HHIP , IGFBP3 , and SFRP1 in HB cells, thereby leading to strong repression through DNA methylation and histone ...of genes involved in cell cycle ...
11
Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer
... adjunct tumor classification, but also for clinical outcome ...predefined tumor suppressor genes not necessary specific to any tumor type) suggested the need to investigate regions that ...
11
Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy
... “tumor suppressor genes” or “negative regulated protein” or “antioncogene” This search identified 22 TSGs including breast cancer 1 (BRCA1), tumor protein p53 (TP53), phosphatase and tension ...
10
Tumor suppressor genes as negative growth regulators in development and differentiation
... Int J Dc\' Bioi 39 R95 907 (19951 895 Rl'view Tumor suppressor genes as negative growth regulators in development and differentiation DAVID H GUTMANN Departments of Neurology Genetics and Pediatrics,[.] ...
13
Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer
... Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent ...
11
Compensation by tumor suppressor genes during retinal development in mice and humans
... presence of minor focal retinal dysplasia, as reported pre- viously [13]. The laminar structure and synaptogenesis outside the regions of focal dysplasia were not substan- tially disrupted (Fig. 6A–I and data not shown), ...
21
Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients
... and tumor suppressor profile in patients with common SCCT (>45 years) compared with SCCT in younger patients (≤45 years) using quantitative PCR (qPCR) and EGFR, p53, p16, and CXCR4 ...
9
Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes LATS1 and LATS2 in Human Cancer
... ARGE tumor suppressor (Lats)/Warts (Wts) plays a crit- ical role in mediating Hippo (Hpo) growth-inhibitory sig- naling but its role in human cancer is less clear (recently reviewed in Harvey et ...hLATS1/2 ...
9
Original Article miRNA-627 inhibits cell proliferation and cell migration, promotes cell apoptosis in prostate cancer cells through upregulating MAP3K1, PTPRK and SRA1
... Abstract: Objective: miRNAs, altered expression manner in prostate cancer, have involved in cancer development by regulating proliferation, differentiation, invasion, metabolism and apoptosis. Recently, it has been found ...
7
Mitochondria, cholesterol and cancer cell metabolism
... favoring tumor invasion, angiogenesis and immunosurveillance suppression ...many tumor types rely on oxidative metabo- lism, glucose flux is not necessarily coupled to oxidative glucose ...of tumor ...
24
Warncke, Simon (2010): Inhibierung von Methyltransferasen und Click-chemische Methoden zur selektiven Modifikation von Oligonukleotiden. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... In tumor cells, in addition to a reduced overall genomic methylation level, local hypermethylation of gene promotors can be ...of tumor suppressor genes and subsequently to the malfunctioning ...
202
Epstein Barr virus: a prime candidate of breast cancer aetiology in Sudanese patients
... two genes encoding for EBV viral ...six tumor suppressor genes was investigated using methylation specific ...tumour suppressor genes investigated BRCA1, BRCA2, and p14 appeared ...
5
Review Article Epigenetics and Epigenetic Alterations in Pancreatic Cancer
... certain tumor suppressor genes [56, 160, 161], and some studies indicate that cancers of older patients have more aberrant methylation than those in younger patients ...of genes that do not ...
17
Original Article FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells
... with tumor suppressor gene silenc- ing in ...these tumor suppressor genes, whereas over-expression of FOXA1 showed the opposite ...the tumor suppressor genes ...
11
Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells
... three tumor suppressor genes (p16 Ink4a and p19 Arf from Cdkn2a and p15 Ink4b from Cdkn2b), was found to be a barrier to reprogramming [20, 21], further emphasizing the relationship between ...
12
Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
... Wnt/β-catenin pathway, also called canonical Wnt pathway, is crucial to embryo development and adult tissue homeostasis [1, 2]. Aberrant activation of this pathway can cause uncontrolled cell growth and cell malignant ...
10