Tumor vaccine
Tumor heterogeneity as a rationale for a multi-epitope approach in an autologous renal cell cancer tumor vaccine
... in tumor lysates and initiated immune response in mice, ...a vaccine need to be proven by appropriate assays; First, the antigenicity as the property of an antigen to be recognized by the specific immune ...
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Glioma Stem Cell Targeted Dendritic Cells as a Tumor Vaccine Against Malignant Glioma
... DC vaccine was obtained by mixing DCs with lysate of glioma stem ...DC vaccine was charactirizated through the mixed lymphocyte responses and cell killing experiment in ...
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Original Article Combination antitumor effect of GM-CSF tumor vaccine with cisplatin for mice with subcutaneous transplanted tumor
... modify tumor vaccine with the aim of enhancing the antitu- mor activity of ...LL/2 tumor cell vaccine modified with a co-expressing mouse GM-CSF and IL-18 plasmid may significantly inhibit ...
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Doxorubicin and paclitaxel enhance the antitumor efficacy of vaccines directed against HER 2/neuin a murine mammary carcinoma model
... allogeneic tumor vaccine: overall results of a randomized trial of the Southwest Oncology ...autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with ...
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Bottle-neck Problems of Current Human Cancer Therapy
... Autologous Dendritic Cell (DC)-Based Tumor Vaccine Therapy for Human Cancer. Human DC preparations[r] ...
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Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses
... HPV tumor vaccine led to strong functional cytotoxic and helper T-cell responses in mice, but in much lower volumes as compared to intradermal vaccination using a classical needle and ...
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KBMA Listeria monocytogenes is an effective vector for DC mediated induction of antitumor immunity
... NY-ESO-1 protein, another melanoma-associated antigen, delivered the antigen for presentation by MHC class I and class II molecules independent of the MHC haplotype of the DC donor. A mouse therapeutic tumor model ...
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Exosomes derived from rAAV/AFP-transfected dendritic cells elicit specific T cell-mediated immune responses against hepatocellular carcinoma
... cell-free vaccine that carries tumor antigens and exhibit anti- gen-presenting activity, is effective to stimulate naive T cell proliferation in vitro and induce T cell activation to become antigen-specific ...
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Current state of treatment for primary cutaneous melanoma
... antigen vaccine capable of generating both a humoral and cellular response in a subset of ...this vaccine was evaluated in a randomized phase II study involving a high-risk stage III patient population, and ...
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FRET microscopy autologous tumor lysate processing in mature dendritic cell vaccine therapy
... - tumor lysate anti- gen complexes, as a function of time after the maturation stimulus, is in good agreement with the results from pre- vious biological studies on mouse [9] and human DC ...autologous ...
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Intratumorally injected pro-inflammatory allogeneic dendritic cells as immune enhancers: a first-in-human study in unfavourable risk patients with metastatic renal cell carcinoma
... melanoma tumor regression, following therapeutic PD-1 blockade requires pre-existing CD8+ T ...adjacent tumor cells (potentially indicating the presence of CD8-derived IFN-γ) was associated with the ...
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Construction and Evaluation of a Combined Cyclophosphamide/Nanoparticle Anticancer Vaccine
... immunosurveillance [13]. In these situations, toll-like receptor (TLR) activation may be of benefit [14]. TLR detect a wide spectrum of pathogen associated molecular patterns (PAMPs), from unique bacterial products such ...
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Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
... DNA vaccine encoding specific tumor-associated transgenes may provide a strong stimulus, due to physical stress and/or a DNA backbone signal which activates skin DCs, that enables DCs fully mature and thus ...
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Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine
... of tumor proteins and is multivalent in terms of tumor antigens (Copier and Dalgleish ...defined tumor antigens in TCV therapy renders the antibody responses difficult to ...by tumor growth ...
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HERBS AS TRADITIONAL MEDICINES: A REVIEW
... bacterial vaccine is cultivation of the specific organism in a suitable broth ...Typhoid vaccine, cholera vaccine, plague vaccine, pertussis vaccine, BCG vaccine are the ...
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Anti-cancer Immunotherapy Epitope-peptides Vaccination in Patients with Refractory/Persistent Disease of Cervical Cancer and Ovarian Cancer (Phase 1 Studies)
... In phase 1 enrollees, there were few of SCC and the adherence to URLC10 was low as 50%. Usual frequency of subtypes in newly diagnosed uterine cancer showed that SCC covers about 70% of uterine CC in Japan. In our ...
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A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer
... the tumor microenvironment from the laboratory to the ...whole tumor cancer vaccine is novel and has not been tested in the ...solid tumor mouse models show that blocking VEGF enhances de novo ...
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Computational Prediction of Tumor Specific Antigens as Potential Vaccine Candidates against Germ line Mutations in Endometrial Cancer
... relatively tumor-specific and widely used for monitoring patients with squamous cell ...particular tumor marker for uterine corpus carcinoma, several tumor markers incorporations including cancer ...
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Pilot study of p62 DNA vaccine in dogs with mammary tumors
... DNA vaccine in rodents with various types of transplantable ...DNA vaccine on mammary tumors of dogs. We found that p62 DNA vaccine administered ...and tumor encapsulation via fibrotic ...
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Combination immunotherapy and active specific tumor cell vaccination augments anti cancer immunity in a mouse model of gastric cancer
... the tumor vaccination with GM-CSF (LRAST) did not further increase but rather tended to decrease the tumor-specific immune response in vitro as determined by tumor-specific IFN-g secretion and ...
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