Tumor vasculature
T Cells Bearing a Chimeric Antigen Receptor Against the Tumor Vasculature Destroy the Tumor Endothelium and Result in Tumor Regression
... enable tumor growth, provide a barrier to immune infiltration, and serve as a source of pro-tumorigenic ...Targeting tumor blood vessels for destruction, or tumor vascular disruption therapy, can ...
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<p>Relationship of B7-H3 expression in tumor cells and tumor vasculature with FOXP3+ regulatory T cells in renal cell carcinoma</p>
... both tumor cells and the tumor vasculature, the numbers of tumor- in fi ltrating FOXP3+ cells, and patient ...undergone tumor resection between June 2005 and October 2010 at The Cancer ...
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Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial–mesenchymal transition inhibition
... However, tumor vessels are influenced by excessive pro-angiogenic factors, resulting in deformed structures that facilitate the intravasation of tumor cells into the circulation and subsequent ...abnormal ...
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Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin
... abnormal tumor vasculature [37]. Anatomically, these abnormal tumor vessels are characterized by an irregular, tortuous and disorganized architecture with a highly dysfunctional and leaky endothelial ...
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Tumor endothelial marker 1–specific DNA vaccination targets tumor vasculature
... of tumor control. It also generated robust CTL activity against tumor cell proper immunodominant epitopes, such as AH1 and ...the vasculature antigen ...the tumor vasculature, includ- ...
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Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
... 3 tumor types, Sema3g, a new member of the Sema3 family that repels ECs and inhibit tumor angiogenesis (21), was slightly upregulated in the dysplastic stages and in tumors com- pared with normal tissues ...
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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
... functional tumor vas- culature, revealing (Figure 2; left panel) demonstra- ble decrease in vascularity of SU6668-treated tumors and modest reduction in tumors treated with ...the tumor vasculature ...
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Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium
... for tumor vasculature (Fig- ure ...contained tumor cells (yellow arrow) while vessels with- out tumor cells in them had minimal Cx43 signals (white ...metastatic tumor in the lung with ...
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Targeting tumor vasculature through oncolytic virotherapy: recent advances
... Targeting tumor vasculature by oncolytic viruses (OVs) is an attractive strategy that offers several advantages over nontargeted viruses, including improved tumor viral entry, direct antivascular ...
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Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery
... with tumor cells, endothelial cells of tumor display several advantages which promote tumor vasculature an attractive target for peptide discovery ...[5,18,25,26]. Tumor endothe- lial ...
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Platelet-camouflaged nanococktail: Simultaneous inhibition of drug-resistant tumor growth and metastasis via a cancer cells and tumor vasculature dual-targeting strategy
... doping the same amount of DOPE-RhB during the nanoparticle construction. Thus, the cellular uptake of these two NPs could be investigated through the evaluation of intracellular fluorescence. Fluorescence images showed ...
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Cancer anti angiogenesis vaccines: Is the tumor vasculature antigenically unique?
... radiological tumor reductions in lung cancer patients (reviewed in ...and tumor cells ...in tumor cells and in placenta include VEGF family members [112], FGF/FGFR, survivin [113], calreticulin ...
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Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
... enhanced tumor growth in TRPV4 KO mice, confirms that TRPV4 plays a critical role in tumor ...inhibited tumor growth suggesting that TRPV4 activation-induced vascular maturation improved the efficacy ...
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A review of the development of tumor vasculature and its effects on the tumor microenvironment
... staining tumor sections of head and neck cancers with markers for vessels, perfusion, hypoxia, and proliferation, it becomes apparent that the tumor vasculature intimately shapes the ...the ...
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Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting
... the tumor vasculature ...the tumor parenchyma was increased markedly ...enhanced tumor vasculature targeting may facilitate subsequent extravasation of the liposomes into tumor ...
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Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma
... Abstract: Tumor angiogenesis is required for tumor growth and metastasis, and the Ang/Tie-2 axis plays a pivotal role in ...abnormal tumor B7-H3 expression is frequently associated with a poor ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... dysfunctional tumor vasculature limits the efficiency of oxygenation and drug delivery to reduce treatment ...of tumor vascular normalization (VN), which inhibits angiogenesis to improve vessel ...
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Incorporation of Tumor Vasculature Targeting Motifs into Moloney Murine Leukemia Virus Env Escort Proteins Enhances Retrovirus Binding and Transduction of Human Endothelial Cells
... of tumor-activated endothelial cells provide an advantageous locus for targeting gene therapy vectors to angiogenic tissues and/or tumor ...these tumor vasculature targeting motifs (TVTMs) ...
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Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes
... per tumor was measured and extrapolated to estimate a num- ber of bound VE-cad epitopes per ...the tumor vascular network, a single agent could be employed to image or treat a variety of different ...
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B7-H3 is a new cancer-specific endothelial marker in clear cell renal cell carcinoma
... of tumor cells that stained positive for B7-H3 were quantified in 10% ...the tumor vasculature and the vasculature of adjacent nontumor renal tissue was evaluated and recorded as absent, ...
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