Tumorigenesis and progression
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice
... cancer progression, where seminal vesicle lesions often occur and has been described as phyllodes-like epithelial-stromal ...regulating tumorigenesis and progression in seminal vesicles of TRAMP mice ...
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MicroRNA-490 inhibits tumorigenesis and progression in breast cancer
... Abstract: MicroRNAs are consistently reported to regulate gene expression in all cancer cell types by modulating a wide range of biological processes, including cell proliferation, differen- tiation, and apoptosis, which ...
12
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma
... tumor progression in the following aspects: (1) ROS activates the AMPK pathway that promotes acquisition of the Warburg phenotype in HSP60-KN cells; (2) ROS generated by HSP60 knockdown or by rotenone inhibition ...
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The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer
... Background: SLC34A2 with highest expressions in lung, small intestine and kidney encoded a type 2b sodium-dependent phosphate transporter (NaPi-IIb). In lung, SLC34A2 only expressed in the apical membrane of type II ...
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Role of DKK4 in Tumorigenesis and Tumor Progression
... tumor progression by activating other Wnt non-canonical signaling, such as non-canonical JNK ...in tumorigenesis and progression are different in various kinds of ...
6
Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
... Aberrant cells proliferation is the most basic feature in the tumorigenesis. Studies indicate HIF-1α promotes the proliferation of pancreatic cancer cells through various mechanisms. lncRNA is involved in the ...
11
Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer
... Endometrial Cancer (EC) is one of the most common female cancers. Genome- wide association studies (GWAS) have been investigated to identify genetic polymorphisms that are predictive of EC risks. Here we utilized a ...
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MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
... in cancer [22]. This initial observation further supported the concept of miRNAs being localized to fragile chromo- somal regions. We identified both aldolase A (ALDOA) and triosephosphate isomerase 1 (TPI1), which have ...
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The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
... and progression within endogenous MMTV- Neu tumors in which EphA2 deficiency precedes tumorigenesis, we examined the effects of diminishing EphA2 expression in established tumor ...
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Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis
... epigenetic changes need to occur, in conjunction with oncogene expression, to facilitate complete tumorigenesis. In both models, increased proliferation of neoplastic cells plateaus prior to the stage of frank ...
8
Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model
... to tumorigenesis and cancer ...of tumorigenesis to the prostate in the Pten deficient mice [13], and abolished spontaneous tumorigenesis in Rb1 (+/-) mice ...
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Metabolic Intermediates in Tumorigenesis and Progression
... citrate to acetyl-CoA, thus downregulating lipogenesis and decreasing cytokine stimulation and proliferation regulated by PI3K/Akt signalling pathway [58]. Furthermore, the ratio of acetyl-CoA to coenzyme A in the ...
13
MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression
... and might function as an oncogenic protein in the initiation and metastasis of ovarian carcinoma. MicroRNA 23b (miR-23b) is a critical regulatory factor in the progression of many cancer cell types that targets ...
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ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression
... longer progression-free survival (PFS) than those with lower ATF3 expression; this obser- vation was also confirmed in chromatin immunoprecipi- tation (Ch-IP) experiments with MM cell lines and patient specimens ...
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Original Article Upregulation of HOXA13 as a potential tumorigenesis and progression promoter of LUSC based on qRT-PCR and bioinformatics
... ber of the homeobox genes, HOXA13 has an oncogene-like character in mul- tiple cancers. HOXA13 can enhance gastric cancer cell invasion and the epi- thelial-to-mesenchymal transition (EMT) via the TGF-β signaling ...
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The E cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression
... E-cadherin is a cell–cell adhesion protein fulfilling a prominent role in epithelial differentiation. Data from model systems suggest that E-cadherin is a potent invasion/tumor suppressor of breast cancer. Consistent ...
5
TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β catenin pathway
... Human tumor necrosis factor-α-induced protein-8 like-2 (TIPE2, TNFAIP8L2), located on chromo- some 1q21.2–1q21.3, shared 94% identical amino acid sequence with murine TIPE2 [5]. TIPE2 is a vital nega- tive regulator of ...
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RBM5 inhibits tumorigenesis of gliomas through inhibition of Wnt/β catenin signaling and induction of apoptosis
... underpinning tumorigenesis and progression has been a promising way to develop novel ...or progression by triggering apoptosis and inducing cell cycle G1/S arrest ...
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Original Article Expression characteristics of CDC20 in gastric cancer and its correlation with poor prognosis
... Abstract: The cell division cycle 20 homolog (CDC20) expression is increased in diverse human cancers and plays a vital role in tumorigenesis and progression. However, the clinical significance of CDC20 ...
6
Gold nano-particles (AuNPs) carrying anti-EBV-miR-BART7-3p inhibit growth of EBV-positive nasopharyngeal carcinoma
... the various regulatory mechanisms underlying NPC [39], EBV-encoded miRNAs have been increasingly brought to attention in light of their potential regulatory roles in many aspects [40], including latent virus maintenance ...
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