Type 1 cannabinoid receptor (CB1)
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
... pharmacological CB1 antago- nists SR141716A and AM251 ...wild type mice, we got different results at 7 days after BrdU ...at 1 h and 24 h, which would be in line with the findings by Jin et ...that ...
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Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... of CB1 on glutamatergic neurons eases the behavioural flexibility to relearn or learn a new platform ...the CB1 antagonist AM251 alleviated perseverance in a set-shifting task in rats (Hill et ...of ...
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Pharmacodynamics of cannabinoids
... various cannabinoid-type components called cannabinoids (presently estimated at about ...endogenous cannabinoid receptor ligands were of high signi ...“agonistic” receptor activity were ...
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Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant
... how CB1 receptor antagonists impact patient’s diets and to ascertain whether further research on CB1 receptor antagonists and indeed other anti-obesity medication on dietary composition is ...
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Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
... indicated by increase, no change, and decrease in GTPγS binding, respectively. Data represent percentage of stimulation over basal binding and are mean ± SEM of 3 assays performed in triplicate. (C) Concentration of ...
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Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis
... CB 1 R and AEA are present in cells isolated from BALF and that their expression is strongly increased following bleomycin administration (Figure 3, F and ...CB 1 R expression in the lungs of BL-PF mice ...
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Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages
... 24). CB1 activation in mouse and human WAT reduces mitochondrial mass and function by downregulation of PPARγ coactivator 1α (Ppargc1a), while genetic and pharmacological blockade of CB1 function increases ...
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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health
... CB 1 receptor during the osteogenic differentiation of MSCs har- vested from adult Wistar ...CB 1 receptor is increased during MSC osteogenic dif- ferentiation and is essential for the ...
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Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... as type 2 diabetes and cardiovascular diseases is ...a cannabinoid 1 receptor (CB1R) inverse agonist, was one of the fi rst drugs that reached the European market to treat ...
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Lower circulating endocannabinoid levels in children with autism spectrum disorder
... CB 1 R, CB 2 R : Cannabinoid receptor type-1, type-2; CBCL: Child Behavior Checklist; CGI-S : Clinical global impression- severity; DAGL: Diacylglycerol lipase; DSM-5: Diagnostic ...
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Cannabinoid CB1 Transmission in the Mesolimbic Reward Pathway
... κ-opiate receptor transmission within the VTA in the mediation of opiate-related aversion (Margolis et ...intra-PLC CB1 activation to induce morphine-related place aversion was dependent upon a KOR ...
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The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: A double-blind, randomized control trial
... N-oleoyl-phophatidyl-ethanolamine (NOPE) and epigallocatechin gallate (EGCG) are naturally occurring nutritional ingredients, whose biological properties may enhance compliance to a reduced calorie diet [17-28]. NOPE, a ...
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Anti inflammatory effects of N acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX 2 dependent manner
... LF-PA0021, 1:2000), poly(ADP-ribose) polymerase (PARP) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (Cell Signaling, Leiden, Netherlands, #9542 and #2118, ...8.0), 1 mM EDTA, 0.5 mM EGTA, 1 % ...
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Neuromodulators, stress and plasticity: a role for endocannabinoid signalling
... An important aspect of the HPA axis is its ability to self-regulate. This requires CORT-mediated feedback inhibition (Keller-Wood and Dallman, 1984) at the level of the hippocampus (Jacobson and Sapolsky, 1991), limbic ...
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The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
... Two experiments were conducted in this work. In the first exper- iment, the effect of acute IP administration of the CB1 recep- tor agonist WIN-55,212-2 (Cayman Chemical Company, MI, USA) on L-DOPA-treated rats ...
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The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice
... Cannabinoids delta-9-THC, ACPA, methanand- amide, and endocannabinoid anandamide were reported to produce comparable discriminative stimulus effects (McMahon 2009). The modulatory effects of the cannabinoid CB ...
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PubMedCentral-PMC4905821.pdf
... The CB1 receptor is involved in appetite and consummatory behaviors (Jager and Witkamp, 2014), and previous studies have reported decreases in body weight following pretreatment with the cannabinoid ...
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Interaction Between the Cannabinoid and Vanilloid Systems on Anxiety in Male Rats
... trigger CB1 receptors (Tóth et al., 2009). Stimulation of CB1 receptors can result in desensitization, blockage, or potentiation of TRPV1 channels in neurons co-expressing CB1 receptors and TRPV1 ...
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First Principles Based Simulations for G Protein Coupled Receptor Activation and for Large Scale Nonadiabatic Electron Dynamics
... ter 1, apart from the hierarchical screening of grid points on the potential energy surface, a key ingredient of ActiveGEnSeMBLE is a selection rule that is based on suitable collective variable(s) specific to the ...
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The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets
... classical cannabinoid recep- tors. In concentrations above 1 μM however, adhesion was decreased reflecting studies by Zhao that showed de- creased adhesion of macrophages after WIN treatment ...
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