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Type 2 cannabinoid receptor (CB2R)

Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity

Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity

... The total protein concentrations in the supernatants were determined using a BCA protein assay kit (Aspen, Wuhan, China). The protein extracts were separated using sodium dodecyl sulfate-polyacrylamide gel electro- ...

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Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis

Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis

... of CB2R modulation on survival and other parameters in experimental sepsis induced by cecal ligation and punc- ture (CLP) using CB2R knockout ...case, CB2R knockout mice following CLP-induced sepsis ...

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Original Article CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion

Original Article CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion

... of cannabinoid receptor type 2 (CB2R) by JWH-133 alleviates fibrosis in the repair of rat skeletal muscle ...that CB2R stimulation exerts anti-inflammatory property in sepsis and ...

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Jacob, Wolfgang
  

(2007):


	Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality.


Dissertation, LMU München: Fakultät für Biologie

Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie

... in 1997 (Szallasi and Blumberg, 1999). The channel is activated by both chemical (capsaicin, the red hot chilli pepper ingredient) and physical (noxious heat and low pH) stimuli (Caterina and Julius, 2001). VR1 is ...

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Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis

Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis

... of 2-AG and AEA are increased in liver dis- ease ...that 2-AG and THC induce CB1 mRNA, which is further enhanced by their combination with AA, jointly favoring the progression of fibrosis in ...and ...

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Original Article Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway

Original Article Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway

... CB 2 agonist markedly decreased the MDA level in infarcted heart [25], which is consistent with our results that activation of CB 2 receptor reduced lung MDA level and ele- vated SOD activity in LIRI ...

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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats

Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats

... and type of agonist for CB1 and CB2 receptors, however, these doses and types may not produce the maximal effect on the bladder of ...CB receptor expression in tissues de- pends on the availability of ...

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Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury

Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury

... (1,000 U/L) in PBS. Brains were sectioned into a left and right hemisphere and micro-dissected to separate the cerebral cortex, and processed immediately. To determine BBB permeability, tissues were weighed, homogenized ...

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In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

... We utilized a high-resolution animal PET scanner (SHR- 38000, Hamamatsu Photonics, Japan) under an axial field of view (FOV) of 330 mm, a transaxial FOV of 108 mm, and a transaxial spatial resolution of 2.3 mm in the ...

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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study

Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study

... Endocannabinoid receptor type 2 (CB2) has recently been considered to be an alternative method for target- ing activated microglia using PET ...endo- cannabinoid system in the central nervous ...

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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health

The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health

... CO 2 asphyxiation and cervical dislocation in accordance with European guidelines ...penicillin/streptomycin; 2 mM GlutaMAX; 1 mM L-glutamine; and 1% nonessential amino acids (Invitrogen, ...CO 2 ) ...

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Regulation of Adipose Tissue Metabolism by the Endocannabinoid System

Regulation of Adipose Tissue Metabolism by the Endocannabinoid System

... as type 2 diabetes and cardiovascular diseases is ...a cannabinoid 1 receptor (CB1R) inverse agonist, was one of the fi rst drugs that reached the European market to treat ...withdrawn 2 ...

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MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2.

MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2.

... Figure 2. miR-139 regulates hippocampal function in AD mice. A. miR-139 expression measured by qPCR analysis. B. The escape latency in the Morris Water Maze over 4 days of training. C. Probe tests conducted 4 days ...

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Lower circulating endocannabinoid levels in children with autism spectrum disorder

Lower circulating endocannabinoid levels in children with autism spectrum disorder

... CB 2 R : Cannabinoid receptor type-1, type-2; CBCL: Child Behavior Checklist; CGI-S : Clinical global impression- severity; DAGL: Diacylglycerol lipase; DSM-5: Diagnostic and ...

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Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat

Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat

... dependent N-acyltransferase (NAT) (81). NAT controls the rate-limiting step in anandamide synthesis (82). In amygdala kindling, which was considered as a chronic model of seizure, the cannabinoid receptor ...

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Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

... CB 2 on the JAK/ STAT signaling pathway in primary cultured microglial ...CB 2 agonist ...heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 ...

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Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis

Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis

... G-coupled receptor 55 (GPR55) was proved to be a receptor of many endocannabinoids ...transient receptor potential vanilloid type-1 and type-4 (TRPV-1, -4) [8,9], and nuclear peroxisome ...

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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody

Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody

... protein receptor type 2 (BMPR2), which is essential for embry- ogenesis and has been shown to play clinically-relevant roles in pulmonary vascular homeostasis and remodeling of the postnatal skeleton ...

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The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats

The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats

... for 2 hours at room temperature, and incubated with primary antibodies against DARPP-32 (1:1000), ERK1/2 (1:1000), phospho-DARPP-32 at Thr75 (pDARPP-32; 1:500), phospho- ERK1/2 at Thr202/Tyr204 ...

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Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity

Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity

... Object recognition learning and memory is a process involving multiple items, the contextual clues surrounding them and the temporal order in each they are presented. Effective recognition memory depends on functional ...

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