Ubiquitin-proteasome
Emerging therapies targeting the ubiquitin proteasome system in cancer
... The ubiquitin proteasome system. The ubiquitin proteasome system (UPS) is an elaborate and highly regulated cellular system that mediates selective protein degradation to control the abundance ...
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The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes
... the ubiquitin-protea- some pathway represent new partners that have to be taken into account for the regulation of insulin ...ome-mediated ubiquitin-dependent ...of ubiquitin-proteasome ...
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Polypharmacology of small molecules targeting the ubiquitin– proteasome and ubiquitin-like systems
... the ubiquitin–proteasome system (UPS) and ubiquitin-like signalling systems (UBL) has been considered a promising therapeutic strategy to treat cancer, neurodegenerative and immunological ...
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Rhabdoviruses and the Cellular Ubiquitin-Proteasome System: a Budding Interaction
... membrane-localized ubiquitin ligase containing multiple WW domains, was identified from this ...screen. Ubiquitin ligase Rsp5, the yeast homolog of Nedd4, was able to interact both physically and ...
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The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
... SCF ubiquitin ligases Fbw7 and β-TrCP have been studied for their roles in ...the ubiquitin-proteasome processing of substrates of these ligases promoted ...the ubiquitin- proteasomal ...
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The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
... host ubiquitin proteasome system (UPS) has vital roles in HBV replication as well as virus-related ...protein ubiquitin (Ub) (a process named ubiquitination) and then the labeled proteins are further ...
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Sit4 Phosphatase Is Functionally Linked to the Ubiquitin-Proteasome System
... by proteasome-mediated Interestingly, although sit4-51 and sit4-102 cells showed protein destruction? Such a model is supported by the similar effects with defects of the ubiquitin-proteasome clear ...
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The Ubiquitin–Proteasome System of Saccharomyces cerevisiae
... several ubiquitin-like pro- teins (UBLs), each with a dedicated conjugation machinery: Smt3 (this modification is known as SUMOylation), Rub1 (NEDDylation), Urm1 (urmylation), and the autophagy fac- tors Atg8 and ...
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Genetic inhibition of the ubiquitin proteasome pathway : insights into proteasomal targeting
... the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome” on March 14, 2007 in Molecular Biology of the ...detectable ubiquitin ...
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The ubiquitin-proteasome system in glioma cell cycle control
... the ubiquitin-proteasome pathway in ...the ubiquitin ligase APC/C Cdc20 (Anaphase Promoting Complex/Cyclosome and its activator Cdc20) for its proteolytic degradation by the proteasome in ...
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Analysis of the Protein Kinase A Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin Proteasome Pathway in Capsule Formation
... the ubiquitin proteasome ...the proteasome, including 26S proteasome regulatory subunit N2 (CNAG_06175) and nascent polypeptide-associated complex subunit ␣ (CNAG_04985); and (iii) diverse ...
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The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish
... The ubiquitin proteasome system (UPS) is important for the removal of unnecessary proteins and regulates normal cellular functions through the degradation of a variety of regulatory proteins (Nakayama and ...
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Equine Infectious Anemia Virus and the Ubiquitin-Proteasome System
... of proteasome treatment was determined by observing the status of Ub inside the cells during the time course experiments presented above using our monoclonal an- tibody (the same 2C5 clones used previously) that ...
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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
... the proteasome is a 20S cylinder, the inside of which contains two copies each of the ac- tive sites β1, β2, and β5 (Figure 2) ...the proteasome, referred to as the immunoproteasome, is enriched in cells of ...
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HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
... the ubiquitin- proteasome system impaired in PD and other NDs ...of ubiquitin molecules in order to mark misfolded ...of proteasome impair- ment, parkin formed a complex with the heterodimeric ...
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Hyperthermia depletes Oct4 in mouse blastocysts and stem cells
... prevent Oct4 degradation under hyperthermia (Fig. 2e). We also showed that either the knock down of Dapk1 (i- Dapk1) or the mutation of the Pin1 phosphorylation site abolished the accumulation of polyubiquitinated ...
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Post-translational modification of Parkin and its research progress in cancer
... UBL: ubiquitin‑like domain; UPS: ubiquitin–proteasome system; SP22: 22‑kilodal‑ ton glycosylated form of α‑synuclein; PINK1: PTEN‑induced kinase 1; p‑Ub: phospho‑ubiquitination; BNIP3: Bcl‑2 and ...
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HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses
... the proteasome and degraded MHC upon denervation, HDAC4mKO mice did not show either proteasome activation or decrease in MHC levels, until 4 weeks following denervation, indicating an impairment in the ...
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Ubiquitin conjugating enzyme involved in the immune response caused by pathogens invasion
... Ubiquitin-proteasome pathway (UPP) is a sig- nificant way of protein degradation and modifi- cation in eukaryotic cell and involved in a com- plex series of intracellular processes. As a key component in ...
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Gupta, Rajat (2012): Firefly luciferase mutants as sensors of proteome stress. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... E3 ubiquitin ligase like activity that allows it to ubiquitylate irreparable Hsp70 and Hsp90 bona fide substrates (in vitro and in vivo) and targets them for the ubiquitin-proteasome mediated ...
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