Ugt1a1 gene
Case report: multiple UGT1A1 gene variants in a patient with Crigler-Najjar syndrome
... the gene UGT1A1 leading to Gilbert ’ s syndrome and Crigler-Najjar syndrome types I and ...of UGT1A1 residual enzymatic activity and its affected bilirubin levels and responsiveness to phenobarbital ...
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Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV 1
... between UGT1A1 gene polymorphism and NP- AEs was ...of UGT1A1 can in- duce NP-AEs by increasing plasma DTG ...addition, UGT1A1 gene polymorphism, age, gender, body weight, smoking, and ...
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Variants in the UGT1A1 Gene and the Risk of Pediatric Nonalcoholic Fatty Liver Disease
... the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an ...variant UGT1A1 genotypes reduce the risk for NAFLD ...The UGT1A1 genotypes UGT1A1*6 and ...
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UGT1A1 gene mutation as a marker indicating there is a high risk of Gilbert's syndrome: Theoretical and applied aspects
... Frequency of *28/*28 mutant genotype of UGT1A1 gene associated with Gilbert's syndrome amounted to 13.6 % in the population sampling and it is quite consistent with previously published data. Therefore, a ...
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UGT1A1 gene and neonatal hyperbilirubinemia: a preliminary study from Bengkulu, Indonesia
... dGTP, dTTP), and 0.7 μl KOD polymerase (Novagen, Germany). PCR amplification consisted of an initial denaturation of 2 min at 95 °C followed by 30 cycles of denaturation of 94 °C for 30 s, annealing at 55 °C for 15 s, ...
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Prevalence of Gilbert Syndrome in Bangladesh
... ( UGT1A1*28 and UGT1A1*6 ) among Ban- gladeshi ...that UGT1A1*28 polymorphism is a highly frequent condition among Bangladeshi ...the UGT1A1 gene, which is responsible for over 50 ...
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Original Article Association between hepatic iron deposition, and serum bilirulin levels, mutations of UGT1A1 and HFE gene in patients with hereditary unconjugated hyperbilirubinemia
... in UGT1A1 gene of patients with iron deposition were all higher than the group of patients with- out iron deposition and most patients who had iron deposition and underwent HFE testing also had an intronic ...
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Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer
... in UGT1A1 gene was related with the clinical char- acteristics of gastric cancer, which, to our knowledge, has also not been ...of UGT1A1 gene, which causes high levels of glucuronidation and ...
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Coexpression of Gene Polymorphisms Involved in Bilirubin Production and Metabolism
... G6PD, UGT1A1, and OATP1B1 ...the UGT1A1 gene were also examined, includ- ing the T-3279G phenobarbital responsive enhancer module (PBREM) promoter variant, the (TA) n ...
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Value of plasma SN-38 levels and DPD activity in irinotecan-based individualized chemotherapy for advanced colorectal cancer with heterozygous type UGT1A1*6 or UGT1A1*28
... and gene fragments containing UGT1A1*6 and *28 polymorphism sites were amplified by PCR (25 µL): 2 µL of 10 × PCR buffer (15 mM MgCl 2 ), 2 µL of dNTP ...the UGT1A1 gene were designed as ...
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Relationship between <em>UGT1A1*6/*28</em> gene polymorphisms and the efficacy and toxicity of irinotecan-based chemotherapy
... Notes: UGT1A1 gene polymorphisms were detected using different fluorescent probes specific for UGT1A1*6 or UGT1A1*28 wild-type or mutant ...each UGT1A1 polymorphism, which could then be ...
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Clinical significance of <em>UGT1A1</em> gene polymorphisms on irinotecan-based regimens as the treatment in metastatic colorectal cancer
... detected UGT1A1 gene polymorphisms were enrolled in this ...of UGT1A1*28 homozygous wild-type TA6/6, heterozygous mutant-type TA6/7, and homozy- gous mutant-type TA7/7 was ...of UGT1A1*6 ...
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Association of Neonatal Hyperbilirubinemia With Bilirubin UDP-Glucuronosyltransferase Polymorphism
... syndrome are usually diagnosed just after birth be- cause of their extremely high serum bilirubin con- centrations, and they suffer from severe hyper- bilirubinemia throughout life. Gilbert’s syndrome, on the other hand, ...
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Polymorphisms of the uridine-diphosphoglucuronosyltransferase 1A1 gene and coronary artery disease
... Human UGT1A1 gene cDNA was cloned in 1991, and the entire structure of the gene has since been identified ...only UGT1A1 encoded the enzyme for bilirubin glucuronidation ...the UGT1A1 ...
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The relationship between <em>UGT1A1</em> gene polymorphism and irinotecan effect on extensive-stage small-cell lung cancer
... between UGT1A1 gene polymorphism and irinotecan-related delayed diarrhea and neutropenia, but it is still controver- ...of UGT1A1*28 gene can be used to evaluate the risk of severe neutropenia ...
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Crigler-Najjar Syndrome: A Rare Fatality
... the UGT1A1 gene with insufficient amount of uridine diphosphate glucuronosyl transferase (bilirubin-UGT) ...UDPGT gene (Behrman, Kliegman, Jenson, ...
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Relationship between UGT1A1*6/*28 polymorphisms and severe toxicities in Chinese patients with pancreatic or biliary tract cancer treated with irinotecan-containing regimens
... which UGT1A1 plays an important role. UGT1A1 gene polymorphisms, especially UGT1A1*28 and UGT1A1*6, influence the protein expres- sion and enzyme activity of ...of UGT1A1 ...
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Risk assessment of gene variants for neonatal hyperbilirubinemia in Taiwan
... promoter gene containing GT repeats was amplified by PCR with a sense primer (5’-AGA GCC TGC AGC TTC TCA GA-3’) and an antisense primer (5’-ACA AAG TCT GGC CAT AGG AC-3’) according to a published protocol ...
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Analysis of pharmacogenetic traits in two distinct South African populations
... the UGT1A1 gene could be used more accurately to stratify the two populations in order to perform phar- macogenetic association ...of UGT1A1 SNPs (rs7572563 and rs4148329) and haplotypes on treat- ...
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UGT1A1 polymorphisms in cancer: impact on irinotecan treatment
... the UGT1A1 gene have been implicated in Gilbert syndrome, which shows mild hyperbilirubinemia, and a more aggressive childhood subtype, Crigler–Najjar syn- ...the UGT1A1 gene. Among them, ...
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