Up-Regulation
TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A
... PPM1A up-regulation significantly increased the mRNA and protein levels of PPM1A in MHCC-97L cells com- pared with blank pLVX-Puro (Vector) ...PPM1A up-regulation significantly inhibited the ...
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Avian leukosis virus subgroup J induces its receptor chNHE1 up regulation
... tissues during ALV-J infection. It is well known that high expression of NHE1 is necessary for tumor formation [12]. Elevated NHE1 regulate cell cycle/proliferation, cell migration/invasion and cell death by activation ...
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<p>Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1</p>
... Up-regulation of hsa_circ_0008792 was found to decrease the osteosarcoma cells ’ capacity for migration and invasion and increase apoptosis and these effects are regulated by the ...
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Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma
... most up-regulated genes in osteosarcoma ...The up-regulation of PCOLCE was further confirmed by qRT-PCR using 68 pairs of human osteosarcoma tissues and their adjacent nontumor tissues ...is ...
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Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells
... Recently, several properties of carnosic acid have been reported for its anti-tumor effects [11, 12]. For examples, carnosic acid inhibited growth in multiple cancer cell lines [11], and induced apoptosis in human ...
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Up-regulation of CatSper genes family by selenium
... caused up-regulation in CatSper genes ...more up-regulation compared to the young adult ones, suggesting that the Se treatment had a more profound effect on CatSper expression in the aging ...
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synthase up-regulation for colorectal cancer progression
... To address the mechanism mediating this coordinate expression, as well as its biological significance, we tested whether overexpression of COX2 enhances tumor progression and if this correlates with mPGES1 ...
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-induced, ERK- associated up-regulation of HIF-1α and VEGF-A
... concomitant up- regulation of VEGF-A and HIF-1α ...HIF-1α up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional ...
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<p>Up-Regulation of Tiam1 Promotes the Radioresistance of Laryngeal Squamous Cell Carcinoma Through Activation of the JNK/ATF-2 Signaling Pathway</p>
... the TU686 and Tiam1+ cells. We obtained the following stable cell lines: Tiam1+ (TU686 cells transfected with the Tiam1/C1199 plasmid), Mock (TU686 cells transfected with vector control plasmid), LV/NC (TU686 cells ...
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Original Article Anti-tumor effect of piceatannol through induction of cell apoptosis via up-regulation of microRNA-125b expression on pancreatic cancer
... that up-regulation of miR-125b could re- present a new treatment approach for human ...that up-regulation of miR-125b inhibited cell proliferation, caused down-regu- lation of Bcl-2, ...
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Up-regulation of CNDP2 facilitates the proliferation of colon cancer
... the two (p = 0.259). In contrast, CM displayed very weak or negative staining (Figure 1A). Thus, CN2 immunostain- ing in CC was stronger than in their peritumoral counter- parts and BCD. CN2 expression is markedly ...
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Environmental Sustainability and Regulation: To Down Versus Bottom Up Regulation
... environmental regulation. Numerous new government agencies were set up to protect the American workplace, the environment, highway travelers, and ...
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<p>Up-regulation of CKAP2L expression promotes lung adenocarcinoma invasion and is associated with poor prognosis</p>
... Figure 2B–D, both the mRNA and protein expression levels of CKAP2L were dramatically reduced after transfected with si-CKAP2L 1 or si-CKAP2L 2 compared with the si-NC group. In the following experiments, we selected ...
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Sarcoptic mange breaks up bottom up regulation of body condition in a large herbivore population
... In healthy ibexes, the negative relationship between population abundance and body condition is less pro- nounced in the green period than in the dormant sea- son. This result could be explained by the habitat use of ...
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Original Article Down-regulation of Fra-2 alleviates light-induced retina damage by inhibiting the PARP-1/AIF pathway
... the up-regulation of Fra-2 significantly increased the apoptosis and decreased the proliferation of RGC-5 ...or up-regulation of Fra-2 signifi- cantly increased the expression of PARP-1 and ...
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Original Article Elevated IL-7Rα is linked to recurrence and poorer survival of gastric adenocarcinoma
... Since the expression level of IL-7Rα in GA tis- sues was elevated, the relationship between high and low expression of IL-7Rα was explor- ed on the basis of clinicopathological variabl- es available, including age, ...
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Non-uremic calciphylaxis in alcoholic hepatitis
... The prior reported cases of non-uremic calciphylaxis in alcoholic liver disease occurred in patients with cirrhosis, raising the possibility of protein C and S deficiency contributing to the pathogenesis of calciphylaxis ...
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Regulation of MUC5AC mucin production by the cell attachment dependent pathway involving integrin β1 in NCI H292 human lung epithelial cells
... the regulation of MUC5AC production and that culturing cells under low adhesion conditions induced an up-regulation in the lev- els of MUC5AC ...
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Identification by mRNA Differential Display of Two Up-regulated Genes as Candidate Mediators of AIDS Dementia
... second up-regulated gene, was first isolated from human brain cDNA and is identical in its coding sequence to TWIK1(tandem of P domains in a weak inwardly rectifying K channel), which belongs to a novel structural ...
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Negative regulation of REST on NR2B in spinal cord contributes to the development of bone cancer pain in mice
... concomitant up-regulation in spinal NR2B (2B subunit of N-methyl-D-aspartate receptor, NR2B) protein expression are observed at days 5, 7, 10 and 14 ...negative regulation of REST on NR2B in spinal ...
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