Ursolic acid (UA)
Ursolic Acid Attenuates Renal Injury Induced by Adriamycin in Mice
... of ursolic acid (UA) on adriamy- cin nephropathy in ...of UA group and high dose of UA ...of UA were administered to the mice in treatment groups from the first day after ...
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Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid’s anti-metastatic effect in 4T1 tumor bearing mice
... hematoxylin and eosin; HIF, hypoxia-inducible factor; IHC, immunohistochemical; JNK, c-Jun N-terminal kinase; LEF, lymphoid enhancer binding factor; MDM2, MDM2 proto-oncogene; MFP, mammary fat pad; Myc/Max, v-myc avian ...
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Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats
... Ursolic acid (UA), a pentacyclic triterpenoid compound exits in many ...found UA intervention could alleviate CS induced emphysema in rats ...that UA is an an- tagonist of TGF-β1 [47], ...
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Separation and Purification of Ursolic Acid from Cynomorium songaricum Exacts with Macroporous Resins
... Dynamic adsorption and desorption experiments were carried out in a glass column (17 × 120 mm) wet-packed with the selected resin and the BV of the re- sin was 10 mL. The flow rate of sample solution was 2 BV/h through ...
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A SIMPLE METHOD FOR THE ISOLATION AND ESTIMATION OF URSOLIC ACID IN ALSTONIA SCHOLARIS R BR
... 4. Specificity: It is an ability of the developed analytical method to detect the analyte quantitatively in presence of other compounds, which are expected to be present in the same matrix. The proposed method has been ...
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Original Article Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133 sphere-forming cells in liver stem cells
... [46] Choi BM, Park R, Pae HO, Yoo JC, Kim YC, Jun CD, Jung BH, Oh GS, So HS, Kim YM and Chung HT. Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in ...
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EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM: MODULATORY EFFECT OF URSOLIC ACID ON HYDROGEN PEROXIDE INDUCED DNA DAMAGE IN HUMAN LYMPHOCYTES
... Extract ursolic acid , a pentacyclic triterpenoid from Ocimum sanctum; ii) develop a HPTLC based method for its quantification; and iii) investigate ursolic acid dependent adaptive response to ...
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A Study on the Effect of Ocimum sanctum (Linn.) Leaf Extract and Ursolic Acid on Spermatogenesis in Male Rats
... dose, ursolic acid failed to show any significant effect on the ...rats. Ursolic acid administration did not show any significant change in these hormone levels ...
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A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors
... Ursolic acid (.99.5% purity) and glycyrrhetinic acid (internal standard, . 99.5% purity) were obtained from the National Institute for Food and Drug Control (Beijing, China). High-performance liquid ...
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<p>The Analysis of the Anti-Tumor Mechanism of Ursolic Acid Using Connectively Map Approach in Breast Cancer Cells Line MCF-7</p>
... Recently, connectivity map (CMAP) database has fre- quently been employed to resolve the molecular mechan- isms and target prediction of drugs. 15,16 Liu et al predicted novel histone deacetylase inhibitors by CMAP. 17 ...
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Thin Layer Chromatography and Chemometric Studies of Selected Potentilla Species
... (ursolic acid (UA), oleanolic acid (OA), pomolic acid (PA), tormentic acid (TA), euscaphic acid (EA)) present in the Potentilla spe- ...
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Two series of new semisynthetic triterpene derivatives: differences in anti malarial activity, cytotoxicity and mechanism of action
... is ursolic acid (3β-hydroxyurs-12-en-28-oic acid, UA), which is known to have anti-inflammatory and antihyperlipidemic properties as well as antitumour-promoting effects ...Moreover, UA ...
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Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12- O-tetradecanoylphorbol-13-acetate
... including ursolic acid (UA), oleanolic acid (OA), corosolic acid (CA), 3-epi-corosolic acid (3-epiCA), maslinic acid (MA), and 3-epi-maslinic acid (3-epiMA) were ...
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Isolation of anti mycobacterial compounds from Curtisia dentata (Burm f ) C A Sm (Curtisiaceae)
... contrary, ursolic acid purchased from Sigma Aldrich (Germany) revealed a potent MIC values ranging from10 to 20 μ g/ ml against the same Mycobacterium species in the resa- zurin assay ...oleanoleic ...
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GASTROPROTECTIVE PROPERTY OF PLINIA EDULIS(VELL.) SOBRAL (MYRTACEAE): THE ROLE OF TRITERPENOIDS AND FLAVONOIDS
... of ursolic acid on HCl/ethanol-induced gastric mucosa damage, the antioxidant activity evaluated by DPPH (2,2- diphenyl-1-picryl-hydrazylhydrate) and the quantification of total phenolic content in the ...
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Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents
... Collectively, data from the in vitro studies support that cranberries successfully inhibit three hallmarks of cancer: resisting cell death, sustaining proliferative signaling and activating invasion and metastasis [59]. ...
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Pharmacognostical, phytochemical evaluation and insilico lead finding of Callicarpa macrophylla with hepatoprotective potentials
... Apigenin, Ursolic acid, Crategolic acid, β- Sitosterol, Betulinic acid, α-Amyrenol, Daucosterol, Luteolin-7-O-glucuronide, Apigenin-7-O-glucuronide and Calliterpenone monoacetate almost ...
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Antiprotozoal Activity of a Thymus vulgaris Methanol Extract and Its Fractions
... study design, protozoal growth inhibition and Vero cell cytotoxicity were eva- luated in separate bioassays, although in antiprotozoal studies co-cultures are common practice. The reasons for our alternative approach ...
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Phytochemical Studies from the Roots of Girardinia heterophylla
... ursolic acid. In this study the presence of γ -sitosterol and Ursolic acid in roots of Girardinia heterophylla has been reported for the first ...
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Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia
... maslinic acid (9), ursolic acid (11) and oleanolic acid (12) over the past decade ...Oleanolic acid had selective inhibitory activity against DNA topoisomerase II compared with DNA ...
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