β carboline derivatives
Synthesis of novel β-carboline derivatives with potential antimicrobial and anti helminthic activities
... the β-carboline moiety, which have a valuable biological activities, has been achieved through the nucleophilic substitution of tryptamine to N’-(2-(1H indo-3yl)ethyl) ethane1,2 diamine (I) followed by the ...
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Synthesis and biological evaluation of -carboline derivatives as an anxiolytic agents
... β-carboline derivatives were synthesized and characterized for their structure elucidation. Various chemical and spectral data supported the structure of the compounds thought of. The synthesized ...
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QSAR Analysis on β-carboline as Antitumor Agent
... on β-Carboline derivatives as an anti-tumor agent was performed with 30 compounds of β-Carboline derivatives on different cancer cell lines from reported ...of ...
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Therapeutic journey of synthetic betacarboline derivatives: A short review
... . β-carboline also known as nor-harmane is a nitrogen containing heterocyclic ...of β-carboline is similar to that of tryptamine, with the ethylamine chain re - connected to the indole ring ...
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SYNTHESIS, MOLECULAR DOCKING & EVALUATION OF ANTHELMINTIC ACTIVITY OF 2 (2 AMINO PHENYL) 1HBENZIMIDAZOLE DERIVATIVES
... Benzimidazole possesses both acidic and basic characteristics. The cyclic –NH- group contributes for relatively strongly acidic and also weakly basic property. They possess affinity towards enzyme and protein receptor ...
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Novel hybrids of natural β elemene bearing isopropanolamine moieties: synthesis, enhanced anticancer profile, and improved aqueous solubility
... novel β-elemene derivatives hybridizing isopropanolamine moieties were synthesized with improved aqueous ...the derivatives exhibited more potent antiproliferative activities than parent compound ...
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Biocatalyzed C-C bond formation for the production of alkaloids
... For instance, the -carboline scaffold is a part of numerous agonists and inverse agonists of benzodiazepine receptor.[28,29,33,34] Benzodiazepine receptors play a pivotal role in the con[r] ...
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Synthesis of New Some Imidazole Derivatives Containing ?-Lactam Ring Firyal Waly Askar | Rana Abid Ali | Thanaa Mahdi Al-Mouamin
... In this work 5-methylene-yl - (2-methy –oxazole-4-one) (1H) imidazole (1) were synthesized from the reaction of L-Histidine with acetic anhydride and which converted to the of 5-methylene-yl-(2-methyl 3-amino ...
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Method of producing water soluble glucuronic acid derivatives of vitamin A
... Water soluble glucuronic acid derivatives of vitamin A, including retinoyl β-glucuronide and retinyl βglucuronide, having in vivo activity comparable to retinoicacid and retinol and meth[r] ...
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Vanadatesulfuric Acid-Catalyzed Novel And Eco-Benign One-Pot Synthesis Of Polyhydroquinoline Derivatives Under Solvent-Free Conditions
... / β cos θ , where D is the average crystalline size, λ is the X-ray wavelength used, β is the angular line width at half maximum intensity, and β is the Bragg’s ...
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A NEW HETEROMETALLIC [ALIII-BU2SNIV-BIII ]-Μ-OXOISOPROPOXIDE AND ITS DERIVATIVES WITH Β-DIKETONES: SYNTHETIC, SPECTRAL AND ELEMENTAL STUDIES
... 2700 cm -1 due to enolic stretch. The absence of shift in C=O frequency and disappearence of broad band at 3100-2700 cm -1 in the β-diketonates of μ- oxoisopropoxide compound suggest that bonding takes place ...
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β LACTAMS: A MINI REVIEW OF THEIR BIOLOGICAL ACTIVITY
... heterocyclic derivatives the 3-(2-thienyl) analog I and 3-(3-thienyl) analog II 21 displayed the highest potency in human MCF-7 breast cancer cells with IC50 values of 7 nM and 10 nM, respectively, comparable to ...
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Synthesis and Antibacterial Activities of New β-Lactam and Imidazole Derivatives
... with β-lactam ...lactam derivatives) 5(c-f) was prepared by the heating the 1-((arylidene) amino)2- thioxoimidazolidin-4-one 3(c-f) with chloro acetyl chloride in alkali media (Et 3 N) in ...
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Goodman_unc_0153D_16066.pdf
... of β -halo α -keto ...substituted β -halo α -glycolic acid derivatives in high diastereo- and enantioselectivity utilizing a variety of aromatic aldehydes and α - keto ...
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Synthesis, structural aspects and antimicrobial activity of novel chiral keto amides
... β -Keto amides [4-8] are versatile intermediates for the synthesis of several heterocycles: 3-acyltetramic acids [9], pyrans, [10] alkaloids [11], lactams and spirolactams [12], azetidin- 2-ones [13], as well as ...
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β-Ketoesters in Heterocylic Synthesis: Synthesis of new Dihydropyridine, Tetrahydropyrimidine, Pyrazole, Aminothiophene, Pyrazolopyrimidine Derivatives, and investigation of their antimicrobial activity
... pyrazolopyrimidine derivatives demonstrated significant antimicrobial [11] and antiviral activities ...Its derivatives exhibit antibacterial, antifungal [14], analgesic [15], calcium antagonist [16], anti- ...
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Recent advances in the synthesis of β lactum derivatives using nitrone cycloaddition reactions
... In 1997 and 1998 in their first two contributions in this area Basak et al. described the synthesis of the cis-β-lactams 16 by the Kinugasa reaction of the corresponding nitrones 2 and alkynyl alcohols 14, ...
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DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF β, β DIPHENYL PROPIONIC ACID DERIVATIVES ON ALBINO WISTAR RATS FOR PHARMACEUTICAL INTERESTS
... derivatives are under the category of synthetic compounds with a wide variety of pharmacological activities in the accumulation with anti-inflammatory activity such as antimicrobial, analgesic, hypoglycaemic, ...
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One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives
... In our initial studies, the reaction of β-aminocrotonitrile 1, phenylhydrazine 2, arylglyoxal 3a and 1,3-dimethylbarbituric acid 4a was chosen as a model reaction (Table 1). First we carried out this model ...
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Phosphoramidite-Controlled Asymmetric Hydrogenation with Rhodium Catalysts54-63
... André H. M. de Vries has a Ph.D. (University of Groningen) on asymmetric catalysis. During his Ph.D. he introduced monodentate chiral phosphoramidites (including MonoPhos) as highly successful ligands for conjugate ...
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