β-defensin
Canine β defensin 1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs
... Background: Canine leishmaniasis caused by Leishmania infantum is a parasitic disease of great veterinary significance. Some dogs infected by L. infantum may mount a strong cellular immune response and clear the ...
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Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain
... Mammalian β-defensins are an evolutionarily conserved group of cationic, non-glycosylated antimicrobial and immunomodulatory peptides that are expressed in all mammals, including humans ...human ...
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Effects of Stress on Mouse β Defensin 3 Expression in the Upper Digestive Mucosa
... function. β-defensins constitute an in- tegral component of the innate immune system as antimicrobial peptides, serving as the first line of defense against microbial pathogens at the epithelial surfaces of the ...
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A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression
... and β-defensin-2 and the number of cariogenic species of bacteria, the occurrence of specific bacterial profiles depending on the levels of the determined pro- teins was ...and β-defensin-2 ...
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Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection
... -and β -defensins based on the connectivity of their six cystein residues ...Human β-defensins (hBDs) are expressed mainly in epithelial ...the β -defensin family, was iden- tified by analysis ...
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Human β-defensin-2 production from S. cerevisiae using the repressible MET17 promoter
... human β-defensin-2, (hBD2), using the ...human β-defensin-2 was obtained using the repressible MET17 promoter system than when using the strong constitutive promoter from proteinase B (PRB1) ...
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Isoleucine, an Essential Amino Acid, Induces the Expression of Human β Defensin 2 through the Activation of the G Protein Coupled Receptor ERK Pathway in the Intestinal Epithelia
... It has been proposed that the defensins expression de- crease in patients with CD [5,14]. Therefore, the induc- tion of HBD2 by the administration of Ile is a possible option to treat CD. We also confirmed that oral ...
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Human β defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen specific immunity
... human β -defensin (HBD) 2 to promote antiviral immunity in vitro and in vivo using a receptor-binding domain (RBD) of Middle East respiratory syndrome-coronavirus (MERS-CoV) spike protein (S RBD) as a model ...
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Clinical application of human β defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation
... Conclusions The current study demonstrates that patients with moderate to severe chronic periodontitis present more commonly with the -1654 A/A genotype on the DEFB1 gene and the -159 T/[r] ...
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Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide
... α-, β- and the ...neutrophils, β-defensins are produced directly by epithelial cells, and combat infection both through direct microbicidal action and by modulation of cell-mediated immunity ...human ...
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Keratinocyte Expression of Human β Defensin 2 following Bacterial Infection: Role in Cutaneous Host Defense
... Human  defensin 2 (h  D-2) is thought to play an important role in cutaneous immune defense. We hypothesized that (i) keratinocyte expression of h  D-2, measured by reverse transcription-PCR, would be ...
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Structural and functional characterisation of a novel bovine β defensin gene cluster
... B-actin Antimicrobial peptides Activator protein 1 Antigen presenting cell Spermadhesins aqnl Adenosine triphosphate transferase Bovine beta defensin Bovine endometrium cells sperm assoc[r] ...
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PPARγ as a sensor of lipase activity and a target for the lipase inhibitor orlistat
... of β -defensin 1 (hDB1) & Adipose Differentiation Related Protein (ADRP) increase by up to ...increase defensin protein synthesis, at 10 μ M Orlistat induced a ...induce defensin gene ...
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Vitamin D nutritional status and vitamin D regulated antimicrobial peptides in serum and pleural fluid of patients with infectious and noninfectious pleural effusions
... and β- defensin-2 levels were measured by ELISA using the following kits: Quantikine Human Vitamin D Binding Protein (R&D Systems Europe, Abingdon, UK), HK321 Human LL-37 (Hycult Biotech, Uden, Holland) ...
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Low serum vitamin D levels in type 2 diabetes patients are associated with decreased mycobacterial activity
... human β defensin-2 HBD2, which exert bactericidal activity [15, 16], Because low sera levels of vitamin D were associated with significantly higher intracellular mycobacterial growth, we[r] ...
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Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK TRAF6 p38MAPK signaling pathway in human middle ear epithelial cells
... Recently a new group of receptors, Nacht-LRR, NOD-like Receptor, or CATERPILLAR (NLR), has been reported that resemble and function as intracellular receptors for bacte- rial recognition [19,64,65]. These receptors not ...
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THE RELATIONSHIP BETWEEN INTESTINAL PROTECTIVE MARKERS AND SERUM ENDOTHELIN 1 CONCENTRATIONS IN LOW BIRTH WEIGHT INFANTS WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY
... Azerbaijan Medical University, K. Farajova Scientific Research Institute of Pediatry, Baku, Azerbaijan. ABSTRACT: Perinatal hypoxia results in poor circulation in internal organs, causing damage to the intestinal mucosa. ...
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A dual targeted ?? defensin and exome sequencing approach to identify, validate and functionally characterise genes associated with bull fertility
... the β-defensin gene ...of β -defensins; rs477570826 causes a Cys34Ser change in the predicted gene ENSBTAG00000047421 (encoding BD109), remov- ing the second cysteine and is heterozygous in two ...
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Comparative genomic identification and validation of ?? defensin genes in the Ovis aries genome
... Background: β -defensins are small, cationic, antimicrobial peptides found in species across the plant and animal ...documented. β -defensin genes in Ovis aries (domestic sheep) have been poorly ...
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Ileal antimicrobial peptide expression is dysregulated in old age
... (α-defensins, β-defensins, C-type lectins, RNAses and the cell wall-degrading enzyme lysozyme) were chosen for comparative gene expression analyses in the terminal ...Retnlb), β-defensin 1 ...
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