β-Lactam Antibiotics
Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species
... β-lactam antibiotics cause cell death by inhibition of bacterial cell wall ...of β-lactams has become compromised through the increasing presence of both chromosomally and plasmid-encoded ...
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Trends in Prescribing β Lactam Antibiotics for Treatment of Community Associated Methicillin Resistant Staphylococcus aureus Infections
... Guidelines have suggested that alternatives to  -lactam an- tibiotics be used as empirical therapy for patients presenting with SSTIs in areas where the prevalence of CA-MRSA ex- ceeds 10 to 15% (7). An accurate ...
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Allergy to β-Lactam Antibiotics in Children
... other b-lactams. Accelerated and delayed responses with aminopenicillins and cephalosporins were ob- served intradermally at concentrations of 25 mg/mL. In 2 children with accelerated and delayed responses to ID ...
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Effect of β Lactam Antibiotics with Aminoglycosides on Multidrug Resistance Staphylococcus aureus
... transferred to the laboratory for the next experiments. S. aureus isolates were isolated on blood agar base and MacConkey agar using streaking technique and identified depending on their morphological properties such as ...
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Analysis of the stability and affinity of BlaR-CTD protein to β-lactam antibiotics based on docking and mutagenesis studies
... against β-lactam drugs ...of β-mannanase from Aspergillus niger BK01 (ManBK) were reduced when the conserved C171-C174 disulfide bond was missing, indicating that disulfide bond has a crucial in the ...
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Low Levels of β Lactam Antibiotics Induce Extracellular DNA Release and Biofilm Formation in Staphylococcus aureus
... Our findings demonstrate that  -lactam-induced S. aureus biofilm formation is dependent on the production of eDNA. Pre- vious studies showed that eDNA constitutes a major biofilm ma- trix adhesin in S. aureus ...
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Novel Analytical Method Development and Validation for Cefotetan New β-Lactam Antibiotics in Bulk and Dosage Form
... The aspire and intention of the present study is to expand moreover authenticate a novel as well as rapid reverse phase chromatography separation technique for the [r] ...
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Imide and isatin derivatives as β lactam mimics of β lactam antibiotics
... Microsoft Word CF 521B as published mainmanuscript doc Issue in Honor of Prof Charles Rees ARKIVOC 2002 (vi) 125 144 ISSN 1424 6376 Page 125 ©ARKAT USA, Inc Imide and isatin derivatives as γ lactam mi[.] ...
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Approaches to the biomimetic synthesis of β lactam antibiotics
... The mixture was stirred for 4 h , then the dichloromethane layer was separated, washed with water 3 x 50ml, dried MgS0 4 , and concentrated under reduced pressure to give white crystall[r] ...
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Some studies of the chemical reactivity of β lactam antibiotics
... Gomp 3 .riso n of v alu es of th e r a te co n stan ts fo r n o c ard icin A and the model ^ -lactam s a re com plicated because the re la tio n s h ip ; changes w ith a c id ity . At - -3 .0 0 , K -p -n itro p h ...
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Clinical Isolates of Staphylococcus aureus Show Variation in β Lactamase Production and Are More Susceptible to Antibiotics Conjugated with β Lactamase Inhibitors
... -Lactam antibiotics are a cornerstone in the treatment of bacterial infections on ac- count of its high therapeutic index and selective toxicity—they act by inhibiting the biosynthesis of peptidoglycan, a ...
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Small Molecule Suppression of Drug Resistance in Mycobacterium Smegmatis and Mycobacterium Tuberculosis.
... used β-lactam antibiotics from 8 to ...a β-lactam potentiation spectrum that was orthogonal to traditional β-lactamase ...on β-lactamase activity in ...
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Structure based drug design for ndm1 inhibitors identification of antibacterial resistance
... to β-lactam antibiotics, we identified 5 hits compounds from chembridge database based on structure based drug design method database and successively docked with the active site of ...the ...
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DEVELOPMENT AND VALIDATION OF A HPLC WITH SOLIDPHASE CLEAN UP AND PRE COLUMN DERIVATIZATION METHOD FOR THE SIMULTANEOUS DETERMINATION OF THREE ? LACTAM ANTIBIOTICS RESIDUES IN EGGS
... three β- Lactam antibiotics residues in eggs were calculated by the matrix-matched calibration curves, and only one sample was found to contain amoxicillin at concentration of ...
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Vol 70, No 1 (2018)
... efficiency. β-lactam antibiotics are commonly used to eliminate the residual agrobacteria in subse- quent ...of antibiotics act by interfer- ing with penicillin-binding proteins and by ...
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Clinical and microbiological characteristics of bloodstream infections due to AmpC β lactamase producing Enterobacteriaceae: an active surveillance cohort in a large centralized Canadian region
... all β-lactam antibiotics for infections caused by AE resulted in clinicians changing the definitive antimicrobial therapy to non-β-lactam antibiotics once susceptibility results ...
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Genome sequence of Lysobacter dokdonensis DS-58T, a gliding bacterium isolated from soil in Dokdo, Korea
... 17 β-lactamases for degrading chemicals such as β-lactam antibiotics, biotin-biosynthetic pro- teins, and type IV fimbrial biogenesis proteins that could be involved in gliding motility were ...
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ANTIBACTERIAL ACTIVITY OF NEW β-LACTAM COMPOUND
... β-Lactam antibiotics are still the most used class of antibacterial agents for the treatment of a wide range of human bacterial diseases, because of their pharmacological advantages, such as potent ...
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Risk factors and outcomes in non-transplant patients with extended-spectrum beta-lactamase-producing Escherichia coli bacteremia: a retrospective study from 2013 to 2016
... Carbapenem antibiotics are still considered to be first-line antibiotics for treating ESBL-producing ...these antibiotics has driven the development of carbapenem-re- sistant Enterobacteriaceae ...to ...
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Vol 69, No 1 (2017)
... used antibiotics, and ...plasmid-mediated β-lactamases, which would bind and hydrolyze β-lactam antibiotics, including cephalosporins, could provide protection to penicillin-binding ...
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