β protein
Cudrania cochinchinensis attenuates amyloid β protein-mediated microglial activation and promotes glia-related clearance of amyloid β protein
... amyloid β protein (Aβ)-mediated nitric oxide production and inducible nitric oxide synthase (iNOS) ex- pression in the interferon-γ (IFN-γ) primed BV-2 cells were ...
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Amyloid β-protein oligomers and Alzheimer’s disease
... amyloid β -protein oligomers, and discuss important caveats that should be considered in the evaluation of these ...amyloid β -protein oligomer system remains ...
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Phorbol Esters Affect Multiple Steps in β-Amyloid Precursor Protein Trafficking and Amyloid β-Protein Production
... Because endocytic processing of ,BPP from the cell surface is a major pathway of AP3 produc- tion, the effect of PKC activation by phorbol 12,1 3-dibu- tyrate (PDBu) on endocytic traffic[r] ...
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Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... Altogether, our results show that there is increased pro- duction of TGF-β and an ongoing destruction of brain parenchyma (manifested as increased tau levels) in the brains of SLE patients. We suggest that levels ...
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Deciphering the genesis and fate of amyloid β protein yields novel therapies for Alzheimer disease
... A new diagnostic and treatment paradigm emerges Although questions abound, the field may have accrued enough information about pathogenesis to envision a new way to manage, and ultimately prevent, the disease. In the ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... precursor protein (APP) processing [13, 18]. A β levels are mainly determined by the kinetic of SorLA and APP interaction according to the mathematic model which supports the fact that APP sorting pathway ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...precursor protein (APP) by sequential ...
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Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells
... AR protein expression in a dose-dependent manner (Figure 4A and ...ER β protein expression dose-dependently in both hormone-dependent LNCaP and castration-resistant PC-3 cells in short-term studies ...
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Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
... A bi-specific [67,68] or dual variable domain [69] anti- body combining recognition of the two conformations of Aβ revealed from crystal structure studies, that is, ex- tended conformation on one arm and helical conform- ...
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APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment
... APLP1 protein were further grown, subcloned and subsequently frozen in liquid nitro- ...a protein G column (GE Healthcare Bio-Sciences AB, Uppsala, ...
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Anti–β1 adrenergic receptor antibodies and heart failure: causation, not just correlation
... Excessive isoproterenol stimulation has long been known to produce cardiomyocyte toxicity, myocardial scarring, and CHF (16, 17). More recently, chronic administration of submaximal isoproterenol doses has also been ...
5
Investigation of proliferation and migration of tongue squamous cell carcinoma promoted by three chemokines, MIP-3α, MIP-1β, and IP-10
... MIP-1 β and IP-10 had high expression in CAL-27 and ...MIP-1 β and ...MIP-1 β and IP-10 and their receptors could be potentially used as biomarkers and therapeutic targets for TSCC, especially for ...
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Protein Engineering of Escherichia coli β-glucuronidase
... tetramers, dependent on protein concentration. In order to investigate further whether the biphasic curves were caused by differences in the enzymatic activity of different oligomers, GUS-WT and WT3P24E11 were ...
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Expression of Brugmansia candida Hyoscyamine 6beta-Hydroxylase gene in Saccharomyces cerevisiae and its potential use as biocatalyst
... total protein con- centration of the crude ...the protein reduce the ability of the enzyme to transform the ...This protein presented a lower rate of conversion of hyoscyamine than the untagged ...
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IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation
... Adipogenic differentiation. Adipogenesis protocol of mouse cells was developed as previously described (7, 18). Briefly, 2 days after the cells were confluent, DMEM supplemented with 10% FBS, 1 μM dexametha- sone, 0.5 mM ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... a β -secretase site by the enzyme BACE ( β -site APP cleaving enzyme), which releases a soluble β-cleaved APP fragment (sAPPβ) and leaves a 99 amino acid C-terminal fragment (CTF) known as C99 ...
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The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... ApoE/A β PP animal models might inadequately reflect the interactions between ApoE and TREM2 in the AD brain; microglial activation triggered by ApoE stimulation of murine TREM2 might be more modest in transgenic ...
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Timosaponin BII inhibits the up regulation of BACE1 induced by Ferric Chloride in rat retina
... amyloid β-peptide (Aβ), which is a cleavage form of β-site amyloid precursor protein (β- APP), acts as a fundamental initiator of this disease ...[3]. β-APP is cleaved by ...
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Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
... lipid-cholesterol-carrying protein apolipoprotein E (ApoE) are key participants in the pathogenesis of Alzheimer’s disease ...distinct protein sequences, ApoE2, ApoE3, and ...
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Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... Consistent with previous findings showing that APP is internalised by endocytosis [45] and that PICALM is involved in this process [41], we saw a decrease in the expression of intracellular APP after depletion of PICALM. ...
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