Vectors for gene delivery
Retrotransposon vectors for gene delivery in plants
... in gene delivery; recombination of cDNA with homologous chromosomal sequences can create targeted gene ...retrotransposon-based vectors, therefore, may provide new opportunities for plant ...
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A sight on the current nanoparticle based gene delivery vectors
... DNA delivery to the targeted cells beseems very important at the point of receiving appro- priate ...Although gene therapy can be carried out using naked DNA into the target cells, having negative nature of ...
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Development of non viral vectors for gene delivery based on dynein light chain Rp3
... These vectors are capable of exploring the cell’s architecture in an efficient way to overcome a series of physical, enzymatic and diffusional barriers while still preserving the safety feature of non-viral ...
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Herpes simplex virus vectors for gene delivery to the CNS: Applications in the study of Alzheimer's disease
... 1996). These proteins serve to direct the DNA toward the nucleus, potentially increasing the expression of the transgene. The observation that integrin mediated cell attachment and entry is a common pathway for a number ...
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Mutational Analysis of the Avian Adenovirus CELO, Which Provides a Basis for Gene Delivery Vectors
... a gene delivery vector. We have demonstrated that CELO vectors can package an additional ...Ad5 vectors. Replication-competent CELO vectors bearing either a luciferase expression unit ...
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DEVELOPMENT AND EVALUATION OF NON-VIRAL GENE DELIVERY VECTORS AND THEIR COMBINATION WITH HYDROGEL SCAFFOLD TECHNOLOGY
... non-viral vectors have emerged as promising alternatives due to their potential to overcome many of the limitations of viral ...Non-viral vectors present lower immunogenicity, higher nucleic acid packing ...
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Multiple Immediate-Early Gene-Deficient Herpes Simplex Virus Vectors Allowing Efficient Gene Delivery to Neurons in Culture and Widespread Gene Delivery to the Central Nervous System In Vivo
... widespread gene delivery to the CNS, allowing gene expression over extended ...where vectors with various levels of disablement but containing the same promoter cassette have been tested for ...
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Improved Gene Delivery to Intestinal Mucosa by Adenoviral Vectors Bearing Subgroup B and D Fibers
... antigen delivery systems that are both safe and highly ...adenoviral vectors, derived from human adenoviruses of subgroup C, are poorly efficient in delivering genetic material to differentiated intestinal ...
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Preliminary Study on the Feasibility of p53 Gene Delivery Mediated by Novel Vectors Constructed with CTS and PEI
... for gene therapy to transfer plasmid DNA to targeted cells and make genes express effectively in ...tumor gene carri- ers should possess targeted specificity, high stability, biodegradable, efficient ...
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Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy
... In order to test potential therapeutic strategies using bacteria as gene delivery vectors, fluorescent MCTS were generated. For this purpose, HT-29 cells were sta- bly transfected with pEGFP-N3 ...
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Development and Optimization of Herpes Simplex Virus Vectors for Multiple Long-Term Gene Delivery to the Peripheral Nervous System
... for gene delivery to the peripheral nervous system as it naturally infects sensory nerve terminals before retrograde transport to the cell body in the spinal ganglia where latency is ...HSV vectors ...
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Serotype dependent packaging of large genes in adeno associated viral vectors results in effective gene delivery in mice
... for gene therapy of human diseases due to mutations in large genes, such as cystic fibrosis, Duchenne muscular dystrophy, and hemophilia ...rAAV2/5-mediated gene transfer in animal models of these diseases ...
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In Vivo Assessment of Gene Delivery to Keratinocytes by Lentiviral Vectors
... lentiviral vectors to in- troduce genes into nondividing keratinocytes and, after opti- mization of lentiviral transduction, we determine if lentiviral vectors are superior to retroviral vectors at ...
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Subretinal gene delivery using helper-dependent adenoviral vectors
... Background The eye has several unique features that make it a well suited target organ for gene therapy. It has a highly compartmentalised structure which allows for the effi- cient delivery of a small ...
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Biocleavable Polycationic Micelles as Highly Efficient Gene Delivery Vectors
... Release of foreign DNA from polymeric micelles/DNA complexes into the nucleus of the cells is important for protein expression in the transfected cells. Disulfide link- ages in the polycations can be biocleaved by the ...
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Mapping an Adeno-associated Virus 9-Specific Neutralizing Epitope To Develop Next-Generation Gene Delivery Vectors
... mutant vectors, unlike AAV9, indicating that the residues involved in ...mutant vectors for evasion of polyclonal sera from mice, macaques, or humans previously exposed to ...
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Application of quantum dots as vectors in targeted survivin gene siRNA delivery
... Abstract: Gene silencing using short interfering RNA (siRNA) is becoming an attractive approach for probing gene function in mammalian ...non-viral gene vectors for delivery of survivin ...
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Dendrimers in gene delivery
... (non-viral) vectors for therapeutic nucleic ...such vectors requires the link to be made between dendrimer structure and the morphology and physicochemistry of the respective nucleic acid complexes and, ...
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Non Viral Vectors in Gene Therapy- An Overview
... Non-viral vectors are simple in theory but complex in ...to gene delivery, which is why in spite of various developments in liposome, polymer formulation and optimization, new compounds are ...
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Vectors for gene therapy: A place for DNA transposon
... imperfect vectors for the delivery of the therapeutic ...viral vectors, which have evident advantages but also some serious ...for gene delivery has emerged as a non-viral ...transposon ...
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