Viral Entry and Uncoating
Low pH Is Required for Avian Sarcoma and Leukosis Virus Env-Dependent Viral Penetration into the Cytosol and Not for Viral Uncoating
... of viral entry such as uncoating ...monitor viral penetration into the cytosol, we demonstrated that virions bearing ASLV Env, but not HIV-1 Env, enter the cytosol in a low-pH-dependent ...
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Revisiting HIV 1 uncoating
... HIV uncoating is defined as the loss of viral capsid that occurs within the cytoplasm of infected cells before entry of the viral genome into the ...HIV-1 uncoating has been paved with ...
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Membrane Uncoating of Intact Enveloped Viruses
... Sindbis viral entry in many ways fit the model presented above for intact paramyxovirus membrane ...The viral membranes remain on the outside of the ...emptied viral membranes are released ...
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Filling Knowledge Gaps for Mimivirus Entry, Uncoating, and Morphogenesis
... on viral growth in amoeba ...mimivirus uncoating and ...for entry into amoebas, and particle uncoating (and stargate opening) appears to be depen- dent on phagosome ...the viral factory ...
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Mouse adaptation determinants of poliovirus type 1 enhance viral uncoating.
... the viral replication of mutants on permissive mouse cells, we can assume that the entry of PV into mouse nerve cells requires a process similar to that leading to 135S particles in HEp-2c ...
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An HIV 1 capsid binding protein TRIM11 accelerates viral uncoating
... properly uncoating of HIV-1 capsid or escorting viral DNA into ...perturb uncoating and impede HIV-1 ...block viral DNA nuclear entry by interacting with HIV-1 capsid to increase its ...
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Kinetic Analysis of the Effect of Poliovirus Receptor on Viral Uncoating: the Receptor as a Catalyst
... Poliovirus is a nonenveloped virus of the family Picornaviri- dae. Picornaviruses share an icosahedral capsid architecture consisting of 60 copies of four proteins, VP1, VP2, VP3, and VP4. The surface of the virion is ...
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Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core
... and entry but are defective in synthesizing the early reverse transcription prod- ...in uncoating have similar phenotypes of loss of infectivity and loss of early reverse transcription products, we ...
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Characterization of Vaccinia Virus Intracellular Cores: Implications for Viral Uncoating and Core Structure
... putative entry intermediates, supporting the idea that the viral membranes as well as the nonmembrane protein p11 remain outside while the core crosses the ...
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Avian Reoviruses Cause Apoptosis in Cultured Cells: Viral Uncoating, but Not Viral Gene Expression, Is Required for Apoptosis Induction
... on viral gene expression indicates that apoptosis is induced by parental virus particles at a stage prior to virus ...cell entry or after their intraendosomal conversion to subviral particles upon virus ...
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Receptor Priming of Major Group Human Rhinoviruses for Uncoating and Entry at Mild Low-pH Environments
... HRV uncoating shown here has impor- tant implications for virus ...virus uncoating, the release of the viral genome could occur through multiple sites in the highly symmetric virus ...the ...
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The UL25 Gene Product of Herpes Simplex Virus Type 1 Is Involved in Uncoating of the Viral Genome
... permeabilized, and probed with MAb specific for the major capsid protein VP5. At each time point, all the virus-infected cell samples had similar patterns of distribution of capsids. At 1 h p.i., most of the ...
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Effect of Bafilomycin A1 and Nocodazole on Endocytic Transport in HeLa Cells: Implications for Viral Uncoating and Infection
... the viral capsid, this small pH increase was sufficient to inhibit viral ...of viral infectivity since cargo remains trapped in the early endo- somes in the presence of the drug, where factors ...
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Growth of the parvovirus minute virus of mice MVMp3 in EL4 lymphocytes is restricted after cell entry and before viral DNA amplification: cell-specific differences in virus uncoating in vitro.
... of viral DNA in nuclear fractions was monitored at different time ...single-stranded viral DNA were found for both ...and entry has been overcome by both ...between viral DNA inside the ...
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Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity
... than entry or intra- cellular transport represents the limiting step in ...improved uncoating capacity as compared to the parental ...vector uncoating are barriers that limit AAV vector-mediated ...
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Uncoating of non-enveloped viruses
... virus entry [54, 55]. Protein VI also links to the viral double-strand DNA of about 36 kb, which is condensed by proteins, VII, V and ...a viral protease [56, ...
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Uncoating of non-enveloped viruses
... virus entry [54, 55]. Protein VI also links to the viral double-strand DNA of about 36 kb, which is condensed by proteins, VII, V and ...a viral protease [56, ...
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Two Retroviral Entry Pathways Distinguished by Lipid Raft Association of the Viral Receptor and Differences in Viral Infectivity
... the entry pathway used by ASLV-A, we hope not only to gain a better understanding of the mechanism by which this retrovirus enters cells but also to obtain new insights into how lipid raft-associated cargo is ...
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Structural Insights into Calicivirus Attachment and Uncoating
... It is possible then that cell surface glycans, such as ␣ 2,6-sialic acid in the case of FCV and histo-blood group antigens in the case of the noroviruses, are the sites of initial attachment and principal determinants of ...
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Protease-Dependent Uncoating of a Complex Retrovirus
... retroviral uncoating, a process during which incoming retroviral cores are altered to allow the integration of the viral genome into host chromosomes, is poorly ...essential viral protease-dependent ...
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